Production of ES1 Plasma Carboxylesterase Knockout Mice for Toxicity Studies

The LD50 for soman is 10–20-fold higher for a mouse than a human. The difference in susceptibility is attributed to the presence of carboxylesterase in mouse but not in human plasma. Our goal was to make a mouse lacking plasma carboxylesterase. We used homologous recombination to inactivate the carb...

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Veröffentlicht in:Chemical research in toxicology 2011-11, Vol.24 (11), p.1891-1898
Hauptverfasser: Duysen, Ellen G, Koentgen, Frank, Williams, Gareth R, Timperley, Christopher M, Schopfer, Lawrence M, Cerasoli, Douglas M, Lockridge, Oksana
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Sprache:eng
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