Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium
Although approximately 20 common genetic susceptibility loci have been identified for breast cancer risk through genome-wide association studies (GWASs), genetic risk variants reported to date explain only a small fraction of heritability for this common cancer. We conducted a four-stage GWAS includ...
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| Veröffentlicht in: | Human molecular genetics 2011-12, Vol.20 (24), p.4991-4999 |
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| creator | Cai, Qiuyin Long, Jirong Lu, Wei Qu, Shimian Wen, Wanqing Kang, Daehee Lee, Ji-Young Chen, Kexin Shen, Hongbing Shen, Chen-Yang Sung, Hyuna Matsuo, Keitaro Haiman, Christopher A. Khoo, Ui Soon Ren, Zefang Iwasaki, Motoki Gu, Kai Xiang, Yong-Bing Choi, Ji-Yeob Park, Sue K. Zhang, Lina Hu, Zhibin Wu, Pei-Ei Noh, Dong-Young Tajima, Kazuo Henderson, Brian E. Chan, Kelvin Y.K. Su, Fengxi Kasuga, Yoshio Wang, Wenjing Cheng, Jia-Rong Yoo, Keun-Young Lee, Jong-Young Zheng, Hong Liu, Yao Shieh, Ya-Lan Kim, Sung-Won Lee, Jong Won Iwata, Hiroji Le Marchand, Loic Chan, Sum Yin Xie, Xiaoming Tsugane, Shoichiro Lee, Min Hyuk Wang, Shenming Li, Guoliang Levy, Shawn Huang, Bo Shi, Jiajun Delahanty, Ryan Zheng, Ying Li, Chun Gao, Yu-Tang Shu, Xiao-Ou Zheng, Wei |
| description | Although approximately 20 common genetic susceptibility loci have been identified for breast cancer risk through genome-wide association studies (GWASs), genetic risk variants reported to date explain only a small fraction of heritability for this common cancer. We conducted a four-stage GWAS including 17 153 cases and 16 943 controls among East-Asian women to search for new genetic risk factors for breast cancer. After analyzing 684 457 SNPs in 2062 cases and 2066 controls (Stage I), we selected for replication among 5969 Chinese women (4146 cases and 1823 controls) the top 49 SNPs that had neither been reported previously nor were in strong linkage disequilibrium with reported SNPs (Stage II). Three SNPs were further evaluated in up to 13 152 Chinese and Japanese women (6436 cases and 6716 controls) (Stage III). Finally, two SNPs were evaluated in 10 847 Korean women (4509 cases and 6338 controls) (Stage IV). SNP rs10822013 on chromosome 10q21.2, located in the zinc finger protein 365 (ZNF365) gene, showed a consistent association with breast cancer risk in all four stages with a combined per-risk allele odds ratio of 1.10 (95% CI: 1.07-1.14) (P-value for trend = 5.87 × 10−9). In vitro electrophoretic mobility shift assays demonstrated the potential functional significance of rs10822013. Our results strongly implicate rs10822013 at 10q21.2 as a genetic risk variant for breast cancer among East-Asian women. |
| doi_str_mv | 10.1093/hmg/ddr405 |
| format | Article |
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We conducted a four-stage GWAS including 17 153 cases and 16 943 controls among East-Asian women to search for new genetic risk factors for breast cancer. After analyzing 684 457 SNPs in 2062 cases and 2066 controls (Stage I), we selected for replication among 5969 Chinese women (4146 cases and 1823 controls) the top 49 SNPs that had neither been reported previously nor were in strong linkage disequilibrium with reported SNPs (Stage II). Three SNPs were further evaluated in up to 13 152 Chinese and Japanese women (6436 cases and 6716 controls) (Stage III). Finally, two SNPs were evaluated in 10 847 Korean women (4509 cases and 6338 controls) (Stage IV). SNP rs10822013 on chromosome 10q21.2, located in the zinc finger protein 365 (ZNF365) gene, showed a consistent association with breast cancer risk in all four stages with a combined per-risk allele odds ratio of 1.10 (95% CI: 1.07-1.14) (P-value for trend = 5.87 × 10−9). In vitro electrophoretic mobility shift assays demonstrated the potential functional significance of rs10822013. Our results strongly implicate rs10822013 at 10q21.2 as a genetic risk variant for breast cancer among East-Asian women.</description><identifier>ISSN: 0964-6906</identifier><identifier>EISSN: 1460-2083</identifier><identifier>DOI: 10.1093/hmg/ddr405</identifier><identifier>PMID: 21908515</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Alleles ; Asia ; Association Studies ; Biological and medical sciences ; Breast Neoplasms - genetics ; Cell Line, Tumor ; Chromosomes, Human, Pair 10 - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Genetics of eukaryotes. Biological and molecular evolution ; Genome-Wide Association Study ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical sciences ; Menopause - genetics ; Middle Aged ; Molecular and cellular biology ; Odds Ratio ; Polymorphism, Single Nucleotide - genetics ; Tumors</subject><ispartof>Human molecular genetics, 2011-12, Vol.20 (24), p.4991-4999</ispartof><rights>The Author 2011. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-ea0ec765a63e44c23579a2b4117522f071eb549e32b1b7fb6097be70ce2067963</citedby><cites>FETCH-LOGICAL-c471t-ea0ec765a63e44c23579a2b4117522f071eb549e32b1b7fb6097be70ce2067963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25273580$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21908515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Qiuyin</creatorcontrib><creatorcontrib>Long, Jirong</creatorcontrib><creatorcontrib>Lu, Wei</creatorcontrib><creatorcontrib>Qu, Shimian</creatorcontrib><creatorcontrib>Wen, Wanqing</creatorcontrib><creatorcontrib>Kang, Daehee</creatorcontrib><creatorcontrib>Lee, Ji-Young</creatorcontrib><creatorcontrib>Chen, Kexin</creatorcontrib><creatorcontrib>Shen, Hongbing</creatorcontrib><creatorcontrib>Shen, Chen-Yang</creatorcontrib><creatorcontrib>Sung, Hyuna</creatorcontrib><creatorcontrib>Matsuo, Keitaro</creatorcontrib><creatorcontrib>Haiman, Christopher A.</creatorcontrib><creatorcontrib>Khoo, Ui Soon</creatorcontrib><creatorcontrib>Ren, Zefang</creatorcontrib><creatorcontrib>Iwasaki, Motoki</creatorcontrib><creatorcontrib>Gu, Kai</creatorcontrib><creatorcontrib>Xiang, Yong-Bing</creatorcontrib><creatorcontrib>Choi, Ji-Yeob</creatorcontrib><creatorcontrib>Park, Sue K.</creatorcontrib><creatorcontrib>Zhang, Lina</creatorcontrib><creatorcontrib>Hu, Zhibin</creatorcontrib><creatorcontrib>Wu, Pei-Ei</creatorcontrib><creatorcontrib>Noh, Dong-Young</creatorcontrib><creatorcontrib>Tajima, Kazuo</creatorcontrib><creatorcontrib>Henderson, Brian E.</creatorcontrib><creatorcontrib>Chan, Kelvin Y.K.</creatorcontrib><creatorcontrib>Su, Fengxi</creatorcontrib><creatorcontrib>Kasuga, Yoshio</creatorcontrib><creatorcontrib>Wang, Wenjing</creatorcontrib><creatorcontrib>Cheng, Jia-Rong</creatorcontrib><creatorcontrib>Yoo, Keun-Young</creatorcontrib><creatorcontrib>Lee, Jong-Young</creatorcontrib><creatorcontrib>Zheng, Hong</creatorcontrib><creatorcontrib>Liu, Yao</creatorcontrib><creatorcontrib>Shieh, Ya-Lan</creatorcontrib><creatorcontrib>Kim, Sung-Won</creatorcontrib><creatorcontrib>Lee, Jong Won</creatorcontrib><creatorcontrib>Iwata, Hiroji</creatorcontrib><creatorcontrib>Le Marchand, Loic</creatorcontrib><creatorcontrib>Chan, Sum Yin</creatorcontrib><creatorcontrib>Xie, Xiaoming</creatorcontrib><creatorcontrib>Tsugane, Shoichiro</creatorcontrib><creatorcontrib>Lee, Min Hyuk</creatorcontrib><creatorcontrib>Wang, Shenming</creatorcontrib><creatorcontrib>Li, Guoliang</creatorcontrib><creatorcontrib>Levy, Shawn</creatorcontrib><creatorcontrib>Huang, Bo</creatorcontrib><creatorcontrib>Shi, Jiajun</creatorcontrib><creatorcontrib>Delahanty, Ryan</creatorcontrib><creatorcontrib>Zheng, Ying</creatorcontrib><creatorcontrib>Li, Chun</creatorcontrib><creatorcontrib>Gao, Yu-Tang</creatorcontrib><creatorcontrib>Shu, Xiao-Ou</creatorcontrib><creatorcontrib>Zheng, Wei</creatorcontrib><title>Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium</title><title>Human molecular genetics</title><addtitle>Hum Mol Genet</addtitle><description>Although approximately 20 common genetic susceptibility loci have been identified for breast cancer risk through genome-wide association studies (GWASs), genetic risk variants reported to date explain only a small fraction of heritability for this common cancer. We conducted a four-stage GWAS including 17 153 cases and 16 943 controls among East-Asian women to search for new genetic risk factors for breast cancer. After analyzing 684 457 SNPs in 2062 cases and 2066 controls (Stage I), we selected for replication among 5969 Chinese women (4146 cases and 1823 controls) the top 49 SNPs that had neither been reported previously nor were in strong linkage disequilibrium with reported SNPs (Stage II). Three SNPs were further evaluated in up to 13 152 Chinese and Japanese women (6436 cases and 6716 controls) (Stage III). Finally, two SNPs were evaluated in 10 847 Korean women (4509 cases and 6338 controls) (Stage IV). SNP rs10822013 on chromosome 10q21.2, located in the zinc finger protein 365 (ZNF365) gene, showed a consistent association with breast cancer risk in all four stages with a combined per-risk allele odds ratio of 1.10 (95% CI: 1.07-1.14) (P-value for trend = 5.87 × 10−9). In vitro electrophoretic mobility shift assays demonstrated the potential functional significance of rs10822013. Our results strongly implicate rs10822013 at 10q21.2 as a genetic risk variant for breast cancer among East-Asian women.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Asia</subject><subject>Association Studies</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - genetics</subject><subject>Cell Line, Tumor</subject><subject>Chromosomes, Human, Pair 10 - genetics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genome-Wide Association Study</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Menopause - genetics</subject><subject>Middle Aged</subject><subject>Molecular and cellular biology</subject><subject>Odds Ratio</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Tumors</subject><issn>0964-6906</issn><issn>1460-2083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1EAQRVsIRCaBDR-AesMGyUn1e8wCKYzyQIrEBtZWuV3ONIzdQ3c7KBu-PUbOAzasSqo695aqLmNvBBwLqNXJdrg-6bqkwTxjK6EtVBLW6jlbQW11ZWuwB-ww5-8AwmrlXrIDKWpYG2FW7PcFjXGg6lfoiGPO0QcsIY48l6m75XN3LKEPlHmbCHPhHkdPiaeQf_AbTAHHwrFwAT-lOJYfeKI87UrmfYoDL1vipzkg_7SIN4t4E8ccUwnT8Iq96HGX6fV9PWLfzs--bi6rqy8XnzenV5XXTpSKEMg7a9Aq0tpLZVyNstVCOCNlD05Qa3RNSraidX1roXYtOfAkwbraqiP2cfHdT-1AnZ-vSrhr9ikMmG6biKH5dzKGbXMdbxolpTBazgbvFwOfYs6J-ketgOZPCs2cQrOkMMNv_972iD68fQbe3QOYPe76NP8l5CfOSKfMGp64OO3_t_AOy6mfKQ</recordid><startdate>20111215</startdate><enddate>20111215</enddate><creator>Cai, Qiuyin</creator><creator>Long, Jirong</creator><creator>Lu, Wei</creator><creator>Qu, Shimian</creator><creator>Wen, Wanqing</creator><creator>Kang, Daehee</creator><creator>Lee, Ji-Young</creator><creator>Chen, Kexin</creator><creator>Shen, Hongbing</creator><creator>Shen, Chen-Yang</creator><creator>Sung, Hyuna</creator><creator>Matsuo, Keitaro</creator><creator>Haiman, Christopher A.</creator><creator>Khoo, Ui Soon</creator><creator>Ren, Zefang</creator><creator>Iwasaki, Motoki</creator><creator>Gu, Kai</creator><creator>Xiang, Yong-Bing</creator><creator>Choi, Ji-Yeob</creator><creator>Park, Sue K.</creator><creator>Zhang, Lina</creator><creator>Hu, Zhibin</creator><creator>Wu, Pei-Ei</creator><creator>Noh, Dong-Young</creator><creator>Tajima, Kazuo</creator><creator>Henderson, Brian E.</creator><creator>Chan, Kelvin Y.K.</creator><creator>Su, Fengxi</creator><creator>Kasuga, Yoshio</creator><creator>Wang, Wenjing</creator><creator>Cheng, Jia-Rong</creator><creator>Yoo, Keun-Young</creator><creator>Lee, Jong-Young</creator><creator>Zheng, Hong</creator><creator>Liu, Yao</creator><creator>Shieh, Ya-Lan</creator><creator>Kim, Sung-Won</creator><creator>Lee, Jong Won</creator><creator>Iwata, Hiroji</creator><creator>Le Marchand, Loic</creator><creator>Chan, Sum Yin</creator><creator>Xie, Xiaoming</creator><creator>Tsugane, Shoichiro</creator><creator>Lee, Min Hyuk</creator><creator>Wang, Shenming</creator><creator>Li, Guoliang</creator><creator>Levy, Shawn</creator><creator>Huang, Bo</creator><creator>Shi, Jiajun</creator><creator>Delahanty, Ryan</creator><creator>Zheng, Ying</creator><creator>Li, Chun</creator><creator>Gao, Yu-Tang</creator><creator>Shu, Xiao-Ou</creator><creator>Zheng, Wei</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20111215</creationdate><title>Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium</title><author>Cai, Qiuyin ; Long, Jirong ; Lu, Wei ; Qu, Shimian ; Wen, Wanqing ; Kang, Daehee ; Lee, Ji-Young ; Chen, Kexin ; Shen, Hongbing ; Shen, Chen-Yang ; Sung, Hyuna ; Matsuo, Keitaro ; Haiman, Christopher A. ; Khoo, Ui Soon ; Ren, Zefang ; Iwasaki, Motoki ; Gu, Kai ; Xiang, Yong-Bing ; Choi, Ji-Yeob ; Park, Sue K. ; Zhang, Lina ; Hu, Zhibin ; Wu, Pei-Ei ; Noh, Dong-Young ; Tajima, Kazuo ; Henderson, Brian E. ; Chan, Kelvin Y.K. ; Su, Fengxi ; Kasuga, Yoshio ; Wang, Wenjing ; Cheng, Jia-Rong ; Yoo, Keun-Young ; Lee, Jong-Young ; Zheng, Hong ; Liu, Yao ; Shieh, Ya-Lan ; Kim, Sung-Won ; Lee, Jong Won ; Iwata, Hiroji ; Le Marchand, Loic ; Chan, Sum Yin ; Xie, Xiaoming ; Tsugane, Shoichiro ; Lee, Min Hyuk ; Wang, Shenming ; Li, Guoliang ; Levy, Shawn ; Huang, Bo ; Shi, Jiajun ; Delahanty, Ryan ; Zheng, Ying ; Li, Chun ; Gao, Yu-Tang ; Shu, Xiao-Ou ; Zheng, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-ea0ec765a63e44c23579a2b4117522f071eb549e32b1b7fb6097be70ce2067963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Asia</topic><topic>Association Studies</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - genetics</topic><topic>Cell Line, Tumor</topic><topic>Chromosomes, Human, Pair 10 - genetics</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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Hong</creatorcontrib><creatorcontrib>Liu, Yao</creatorcontrib><creatorcontrib>Shieh, Ya-Lan</creatorcontrib><creatorcontrib>Kim, Sung-Won</creatorcontrib><creatorcontrib>Lee, Jong Won</creatorcontrib><creatorcontrib>Iwata, Hiroji</creatorcontrib><creatorcontrib>Le Marchand, Loic</creatorcontrib><creatorcontrib>Chan, Sum Yin</creatorcontrib><creatorcontrib>Xie, Xiaoming</creatorcontrib><creatorcontrib>Tsugane, Shoichiro</creatorcontrib><creatorcontrib>Lee, Min Hyuk</creatorcontrib><creatorcontrib>Wang, Shenming</creatorcontrib><creatorcontrib>Li, Guoliang</creatorcontrib><creatorcontrib>Levy, Shawn</creatorcontrib><creatorcontrib>Huang, Bo</creatorcontrib><creatorcontrib>Shi, Jiajun</creatorcontrib><creatorcontrib>Delahanty, Ryan</creatorcontrib><creatorcontrib>Zheng, Ying</creatorcontrib><creatorcontrib>Li, Chun</creatorcontrib><creatorcontrib>Gao, Yu-Tang</creatorcontrib><creatorcontrib>Shu, Xiao-Ou</creatorcontrib><creatorcontrib>Zheng, Wei</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human molecular genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Qiuyin</au><au>Long, Jirong</au><au>Lu, Wei</au><au>Qu, Shimian</au><au>Wen, Wanqing</au><au>Kang, Daehee</au><au>Lee, Ji-Young</au><au>Chen, Kexin</au><au>Shen, Hongbing</au><au>Shen, Chen-Yang</au><au>Sung, Hyuna</au><au>Matsuo, Keitaro</au><au>Haiman, Christopher A.</au><au>Khoo, Ui Soon</au><au>Ren, Zefang</au><au>Iwasaki, Motoki</au><au>Gu, Kai</au><au>Xiang, Yong-Bing</au><au>Choi, Ji-Yeob</au><au>Park, Sue K.</au><au>Zhang, Lina</au><au>Hu, Zhibin</au><au>Wu, Pei-Ei</au><au>Noh, Dong-Young</au><au>Tajima, Kazuo</au><au>Henderson, Brian E.</au><au>Chan, Kelvin Y.K.</au><au>Su, Fengxi</au><au>Kasuga, Yoshio</au><au>Wang, Wenjing</au><au>Cheng, Jia-Rong</au><au>Yoo, Keun-Young</au><au>Lee, Jong-Young</au><au>Zheng, Hong</au><au>Liu, Yao</au><au>Shieh, Ya-Lan</au><au>Kim, Sung-Won</au><au>Lee, Jong Won</au><au>Iwata, Hiroji</au><au>Le Marchand, Loic</au><au>Chan, Sum Yin</au><au>Xie, Xiaoming</au><au>Tsugane, Shoichiro</au><au>Lee, Min Hyuk</au><au>Wang, Shenming</au><au>Li, Guoliang</au><au>Levy, Shawn</au><au>Huang, Bo</au><au>Shi, Jiajun</au><au>Delahanty, Ryan</au><au>Zheng, Ying</au><au>Li, Chun</au><au>Gao, Yu-Tang</au><au>Shu, Xiao-Ou</au><au>Zheng, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium</atitle><jtitle>Human molecular genetics</jtitle><addtitle>Hum Mol Genet</addtitle><date>2011-12-15</date><risdate>2011</risdate><volume>20</volume><issue>24</issue><spage>4991</spage><epage>4999</epage><pages>4991-4999</pages><issn>0964-6906</issn><eissn>1460-2083</eissn><abstract>Although approximately 20 common genetic susceptibility loci have been identified for breast cancer risk through genome-wide association studies (GWASs), genetic risk variants reported to date explain only a small fraction of heritability for this common cancer. We conducted a four-stage GWAS including 17 153 cases and 16 943 controls among East-Asian women to search for new genetic risk factors for breast cancer. After analyzing 684 457 SNPs in 2062 cases and 2066 controls (Stage I), we selected for replication among 5969 Chinese women (4146 cases and 1823 controls) the top 49 SNPs that had neither been reported previously nor were in strong linkage disequilibrium with reported SNPs (Stage II). Three SNPs were further evaluated in up to 13 152 Chinese and Japanese women (6436 cases and 6716 controls) (Stage III). Finally, two SNPs were evaluated in 10 847 Korean women (4509 cases and 6338 controls) (Stage IV). SNP rs10822013 on chromosome 10q21.2, located in the zinc finger protein 365 (ZNF365) gene, showed a consistent association with breast cancer risk in all four stages with a combined per-risk allele odds ratio of 1.10 (95% CI: 1.07-1.14) (P-value for trend = 5.87 × 10−9). In vitro electrophoretic mobility shift assays demonstrated the potential functional significance of rs10822013. Our results strongly implicate rs10822013 at 10q21.2 as a genetic risk variant for breast cancer among East-Asian women.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21908515</pmid><doi>10.1093/hmg/ddr405</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0964-6906 |
| ispartof | Human molecular genetics, 2011-12, Vol.20 (24), p.4991-4999 |
| issn | 0964-6906 1460-2083 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3221542 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Alleles Asia Association Studies Biological and medical sciences Breast Neoplasms - genetics Cell Line, Tumor Chromosomes, Human, Pair 10 - genetics Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Menopause - genetics Middle Aged Molecular and cellular biology Odds Ratio Polymorphism, Single Nucleotide - genetics Tumors |
| title | Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T08%3A24%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-oup_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genome-wide%20association%20study%20identifies%20breast%20cancer%20risk%20variant%20at%2010q21.2:%20results%20from%20the%20Asia%20Breast%20Cancer%20Consortium&rft.jtitle=Human%20molecular%20genetics&rft.au=Cai,%20Qiuyin&rft.date=2011-12-15&rft.volume=20&rft.issue=24&rft.spage=4991&rft.epage=4999&rft.pages=4991-4999&rft.issn=0964-6906&rft.eissn=1460-2083&rft_id=info:doi/10.1093/hmg/ddr405&rft_dat=%3Coup_pubme%3E10.1093/hmg/ddr405%3C/oup_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/21908515&rft_oup_id=10.1093/hmg/ddr405&rfr_iscdi=true |