CBX8, a Polycomb Group Protein, Is Essential for MLL-AF9-Induced Leukemogenesis

Chromosomal translocations involving the mixed lineage leukemia ( MLL) gene lead to the development of acute leukemias. Constitutive HOX gene activation by MLL fusion proteins is required for MLL-mediated leukemogenesis; however, the underlying mechanisms remain elusive. Here, we show that chromobox...

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Veröffentlicht in:	Cancer cell 2011-11, Vol.20 (5), p.563-575
Hauptverfasser:	Tan, Jiaying, Jones, Morgan, Koseki, Haruhiko, Nakayama, Manabu, Muntean, Andrew G., Maillard, Ivan, Hess, Jay L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Proliferation Cell Survival - genetics Cell Transformation, Neoplastic - genetics Gene Expression Regulation, Neoplastic HEK293 Cells HeLa Cells Hematopoiesis - genetics Homeodomain Proteins - genetics Humans Leukemia - genetics Mice Mitochondrial Membrane Transport Proteins Molecular Sequence Data Myeloid-Lymphoid Leukemia Protein - genetics Myeloid-Lymphoid Leukemia Protein - physiology Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - physiology Point Mutation Polycomb Repressive Complex 1 Polycomb-Group Proteins Protein Interaction Mapping Repressor Proteins - genetics Repressor Proteins - metabolism Repressor Proteins - physiology Sequence Alignment Translocation, Genetic
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