Reversal of epigenetic silencing of AP-2alpha results in increased zinc uptake in DU-145 and LNCaP prostate cancer cells

Zinc accumulation is lost during prostate carcinogenesis. Recent studies reveal a strong association between prostate cancer progression and the downregulation of the zinc uptake transporters hZip1 and hZip3. The aim of this work was to assess the involvement of epigenetic processes in the disruptio...

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Veröffentlicht in:	Carcinogenesis (New York) 2011-12, Vol.32 (12), p.1773-1781
Hauptverfasser:	Makhov, Peter B., Golovine, Konstantin V., Kutikov, Alexander, Canter, Daniel J., Rybko, Vera A., Roshchin, Dmitry A., Matveev, Vsevolod B., Uzzo, Robert G., Kolenko, Vladimir M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Azacitidine - analogs & derivatives Azacitidine - pharmacology Base Sequence Cancer Biology Cation Transport Proteins - metabolism Cell Line, Tumor Chromatin Immunoprecipitation DNA Methylation DNA Primers Epigenesis, Genetic Gene Silencing Humans Male Promoter Regions, Genetic Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Reverse Transcriptase Polymerase Chain Reaction Transcription Factor AP-2 - genetics Transcription Factor AP-2 - physiology Transcription, Genetic Zinc - metabolism
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