Leucine Biosynthesis Regulates Cytoplasmic Iron-Sulfur Enzyme Biogenesis in an Atm1p-independent Manner

Fe-S clusters (ISCs) are versatile cofactors utilized by many mitochondrial, cytoplasmic, and nuclear enzymes. Whereas mitochondria can independently initiate and complete ISC synthesis, other cellular compartments are believed to assemble ISCs from putative precursors exported from the mitochondria...

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Veröffentlicht in:	The Journal of biological chemistry 2011-11, Vol.286 (47), p.40878-40888
Hauptverfasser:	Bedekovics, Tibor, Li, Hongqiao, Gajdos, Gabriella B., Isaya, Grazia
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC Transporter ATP-Binding Cassette Transporters - metabolism Bioenergetics Cell Respiration Cytoplasm - metabolism DNA, Fungal - metabolism Down-Regulation Iron Metabolism Iron Regulatory Protein 1 - biosynthesis Iron Regulatory Protein 1 - metabolism Iron-Sulfur Protein Leucine - biosynthesis Leucine Synthesis Mitochondria Mitochondria - metabolism Mutation Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Yeast
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