Inflammatory Macrophages Induce Nrf2 Transcription Factor-dependent Proteasome Activity in Colonic NCM460 Cells and Thereby Confer Anti-apoptotic Protection

Adaptation of epithelial cells to persistent oxidative stress plays an important role in inflammation-associated carcinogenesis. This adaptation process involves activation of Nrf2 (nuclear factor-E2-related factor-2), which has been recently shown to contribute to carcinogenesis through the inducti...

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Veröffentlicht in:	The Journal of biological chemistry 2011-11, Vol.286 (47), p.40911-40921
Hauptverfasser:	Sebens, Susanne, Bauer, Iris, Geismann, Claudia, Grage-Griebenow, Evelin, Ehlers, Stefan, Kruse, Marie-Luise, Arlt, Alexander, Schäfer, Heiner
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - immunology Camptothecin - analogs & derivatives Camptothecin - pharmacology Carcinogenesis Cell Line Coculture Techniques Colon - cytology Colon - drug effects Colon - enzymology Colon - metabolism Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - immunology Humans Inflammation Inflammation - immunology Inflammation - metabolism Inflammation - pathology Intracellular Space - drug effects Intracellular Space - metabolism Irinotecan Macrophages - cytology Macrophages - metabolism Molecular Bases of Disease NF-E2-Related Factor 2 - metabolism Oxidative Stress Proteasome Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Reactive Oxygen Species - metabolism TNF-Related Apoptosis-Inducing Ligand - pharmacology Transcription Factors
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