Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A

Tri- and dimethylations of histone H3K9 (H3K9me3/2) and H3K27 (H3K27me3/2), both situated in the "A-R-Kme-S" sequence motif, mediate transcriptional repression of distinct genomic regions. H3K9me3/2 mainly governs constitutive heterochromatin formation, while H3K27me3/2 represses key devel...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genes & development 2011-11, Vol.25 (21), p.2266-2277
Hauptverfasser:	Sengoku, Toru, Yokoyama, Shigeyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Carrier Proteins - chemistry Catalysis Conformation Histone Demethylases - metabolism Histones - chemistry Histones - metabolism Humans Methylation Models, Molecular Molecular Sequence Data Nuclear Proteins - metabolism Protein Binding Protein Structure, Quaternary Protein Structure, Tertiary Research Paper Sequence Alignment
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!