More on FOX News: FOXA1 on the horizon of estrogen receptor function and endocrine response
Estrogen receptor α (ER) is a major driver of breast cancer and the target of endocrine therapy. Full disclosure of the cofactors regulating ER interactions with chromatin and its transcriptional regulatory activity is still elusive. Novel genome-wide profiling tools have mapped ER binding events in...
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| Veröffentlicht in: | Breast cancer research : BCR 2011-04, Vol.13 (2), p.307-307, Article 307 |
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| container_title | Breast cancer research : BCR |
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| creator | Fu, Xiaoyong Huang, Catherine Schiff, Rachel |
| description | Estrogen receptor α (ER) is a major driver of breast cancer and the target of endocrine therapy. Full disclosure of the cofactors regulating ER interactions with chromatin and its transcriptional regulatory activity is still elusive. Novel genome-wide profiling tools have mapped ER binding events in breast cancer cells and delineated cofactors important in ER activity. Among these, the Forkhead protein FOXA1 is emerging as a key factor dictating global chromatin structure and the transcriptional function of ER in breast and non-breast cancer cells. The significance of FOXA1 in the chromatin interactions and transcriptional regulation of both estrogen- and tamoxifen-bound ER, and in supporting tamoxifen-resistant cell growth, may impact current endocrine therapies. |
| doi_str_mv | 10.1186/bcr2849 |
| format | Article |
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Full disclosure of the cofactors regulating ER interactions with chromatin and its transcriptional regulatory activity is still elusive. Novel genome-wide profiling tools have mapped ER binding events in breast cancer cells and delineated cofactors important in ER activity. Among these, the Forkhead protein FOXA1 is emerging as a key factor dictating global chromatin structure and the transcriptional function of ER in breast and non-breast cancer cells. The significance of FOXA1 in the chromatin interactions and transcriptional regulation of both estrogen- and tamoxifen-bound ER, and in supporting tamoxifen-resistant cell growth, may impact current endocrine therapies.</description><subject>Antineoplastic Agents, Hormonal - therapeutic use</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Chromatin</subject><subject>Chromatin - metabolism</subject><subject>Estrogens</subject><subject>Female</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Hepatocyte Nuclear Factor 3-alpha - genetics</subject><subject>Hepatocyte Nuclear Factor 3-alpha - metabolism</subject><subject>Humans</subject><subject>Phenols (Class of compounds)</subject><subject>Receptors, Estrogen - genetics</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Tamoxifen</subject><subject>Tamoxifen - therapeutic use</subject><subject>Transcription (Genetics)</subject><subject>Transcription, Genetic</subject><subject>Viewpoint</subject><issn>1465-542X</issn><issn>1465-5411</issn><issn>1465-542X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UUtLAzEQDqJYX_gPZMGDp2qS3eymPQhFfEHVi0LBQ8gmkzbSTUqyKvrrTWktLShzyMd8j0wyCB0TfE4ILy9qFSgveltojxQl67KCjrbXcAftx_iGMak447uoQwmrGOV4D70--ACZd9nN0yh7hM_Yn6MBmbfaCWQTH-x3wt5kENvgx-CyAApmrQ-ZeXeqtYmVTmfgtFfBOkh8nHkX4RDtGDmNcLQ8D9DLzfXz1V13-HR7fzUYdmvGaNs1pMJGMa4rXGNFtSTE0LzHOdUYsJKG6LwgMi90WTPNNDeG5RSzHpMVK5jJD9DlInf2XjegFbg2yKmYBdvI8CW8tGKTcXYixv5D5JT0UqWA_iKgtv6fgE1G-UYsvzyZTxfmsZyCsM74JFGNjUoMCo5LXDI8v-L8D1UqDY1V3oGxqb9hOFsYVPAxBjCrcQgW852vDXCy_vyV7nfJ-Q_ZUKiI</recordid><startdate>20110420</startdate><enddate>20110420</enddate><creator>Fu, Xiaoyong</creator><creator>Huang, Catherine</creator><creator>Schiff, Rachel</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20110420</creationdate><title>More on FOX News: FOXA1 on the horizon of estrogen receptor function and endocrine response</title><author>Fu, Xiaoyong ; Huang, Catherine ; Schiff, Rachel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b552t-f170fc58d70b0c2da11f239882d0e0caf1d341a34d6b5d5d8ff5320595a7545f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Antineoplastic Agents, Hormonal - therapeutic use</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Chromatin</topic><topic>Chromatin - metabolism</topic><topic>Estrogens</topic><topic>Female</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Hepatocyte Nuclear Factor 3-alpha - genetics</topic><topic>Hepatocyte Nuclear Factor 3-alpha - metabolism</topic><topic>Humans</topic><topic>Phenols (Class of compounds)</topic><topic>Receptors, Estrogen - genetics</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Tamoxifen</topic><topic>Tamoxifen - therapeutic use</topic><topic>Transcription (Genetics)</topic><topic>Transcription, Genetic</topic><topic>Viewpoint</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Xiaoyong</creatorcontrib><creatorcontrib>Huang, Catherine</creatorcontrib><creatorcontrib>Schiff, Rachel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Breast cancer research : BCR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Xiaoyong</au><au>Huang, Catherine</au><au>Schiff, Rachel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>More on FOX News: FOXA1 on the horizon of estrogen receptor function and endocrine response</atitle><jtitle>Breast cancer research : BCR</jtitle><addtitle>Breast Cancer Res</addtitle><date>2011-04-20</date><risdate>2011</risdate><volume>13</volume><issue>2</issue><spage>307</spage><epage>307</epage><pages>307-307</pages><artnum>307</artnum><issn>1465-542X</issn><issn>1465-5411</issn><eissn>1465-542X</eissn><abstract>Estrogen receptor α (ER) is a major driver of breast cancer and the target of endocrine therapy. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Springer Nature OA Free Journals; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | Antineoplastic Agents, Hormonal - therapeutic use Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Line, Tumor Cell Proliferation - drug effects Chromatin Chromatin - metabolism Estrogens Female Genome-Wide Association Study Genomes Genomics Hepatocyte Nuclear Factor 3-alpha - genetics Hepatocyte Nuclear Factor 3-alpha - metabolism Humans Phenols (Class of compounds) Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Tamoxifen Tamoxifen - therapeutic use Transcription (Genetics) Transcription, Genetic Viewpoint |
| title | More on FOX News: FOXA1 on the horizon of estrogen receptor function and endocrine response |
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