Breast cancer growth and metastasis: interplay between cancer stem cells, embryonic signaling pathways and epithelial-to-mesenchymal transition

Induction of epithelial-to-mesenchymal transition (EMT) in cancer stem cells (CSCs) can occur as the result of embryonic pathway signaling. Activation of Hedgehog (Hh), Wnt, Notch, or transforming growth factor-β leads to the upregulation of a group of transcriptional factors that drive EMT. This pr...

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Veröffentlicht in:	Breast cancer research : BCR 2011-06, Vol.13 (3), p.211-211, Article 211
Hauptverfasser:	Takebe, Naoko, Warren, Ronald Q, Ivy, S Percy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone morphogenetic proteins Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer metastasis Cancer prevention DNA binding proteins Epithelial-Mesenchymal Transition Female Growth Hedgehog Proteins - metabolism Humans Mice Neoplasm Metastasis Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Receptors, Notch - metabolism Review Signal Transduction Transforming Growth Factor beta - metabolism Wnt Signaling Pathway
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