Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model

The aim of this prospective, randomized, controlled, double-blind study was to evaluate the effects of tiludronate (TLN), a bisphosphonate, on structural, biochemical and molecular changes and function in an experimental dog model of osteoarthritis (OA). Baseline values were established the week pre...

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Veröffentlicht in:	Arthritis research & therapy 2011-06, Vol.13 (3), p.R98-R98, Article R98
Hauptverfasser:	Moreau, Maxim, Rialland, Pascale, Pelletier, Jean-Pierre, Martel-Pelletier, Johanne, Lajeunesse, Daniel, Boileau, Christielle, Caron, Judith, Frank, Diane, Lussier, Bertrand, del Castillo, Jerome R E, Beauchamp, Guy, Gauvin, Dominique, Bertaim, Thierry, Thibaud, Dominique, Troncy, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anterior cruciate ligament Anterior Cruciate Ligament - pathology Anterior Cruciate Ligament - physiology Anterior Cruciate Ligament - surgery Arthralgia - drug therapy Arthralgia - physiopathology Biomechanical Phenomena - drug effects Biomechanical Phenomena - physiology Bone Density Conservation Agents - pharmacology Diagnosis Diphosphonates - pharmacology Disease Models, Animal Dogs Drug therapy Female Gait - drug effects Gait - physiology Galvanic Skin Response - drug effects Galvanic Skin Response - physiology Health aspects Knee Joint - drug effects Knee Joint - pathology Knee Joint - physiology Male Motor Activity - drug effects Motor Activity - physiology Osteoarthritis Osteoarthritis, Knee - drug therapy Osteoarthritis, Knee - pathology Osteoarthritis, Knee - physiopathology Physiological aspects Synovial Fluid - metabolism Tiludronate
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