Regulation of bone by the adaptive immune system in arthritis
Studies on the immune regulation of osteoclasts in rheumatoid arthritis have promoted the new research field of 'osteoimmunology', which investigates the interplay between the skeletal and immune systems at the molecular level. Accumulating evidence lends support to the theory that bone de...
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| Veröffentlicht in: | Arthritis research & therapy 2011-01, Vol.13 (3), p.219-219 |
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| container_title | Arthritis research & therapy |
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| creator | Okamoto, Kazuo Takayanagi, Hiroshi |
| description | Studies on the immune regulation of osteoclasts in rheumatoid arthritis have promoted the new research field of 'osteoimmunology', which investigates the interplay between the skeletal and immune systems at the molecular level. Accumulating evidence lends support to the theory that bone destruction associated with rheumatoid arthritis is caused by the enhanced activity of osteoclasts, resulting from the activation of a unique helper T cell subset, 'Th17 cells'. Understanding the interaction between osteoclasts and the adaptive immune system in rheumatoid arthritis and the molecular mechanisms of Th17 development will lead to the development of potentially effective therapeutic strategies. |
| doi_str_mv | 10.1186/ar3323 |
| format | Article |
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Accumulating evidence lends support to the theory that bone destruction associated with rheumatoid arthritis is caused by the enhanced activity of osteoclasts, resulting from the activation of a unique helper T cell subset, 'Th17 cells'. 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Understanding the interaction between osteoclasts and the adaptive immune system in rheumatoid arthritis and the molecular mechanisms of Th17 development will lead to the development of potentially effective therapeutic strategies.</description><subject>Adaptive Immunity - physiology</subject><subject>Animals</subject><subject>Arthritis - immunology</subject><subject>Arthritis - metabolism</subject><subject>Bone and Bones - immunology</subject><subject>Bone and Bones - metabolism</subject><subject>Bone Diseases - immunology</subject><subject>Bone Diseases - metabolism</subject><subject>Humans</subject><subject>Osteoclasts - immunology</subject><subject>Osteoclasts - metabolism</subject><subject>Review</subject><issn>1478-6354</issn><issn>1478-6362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLw0AQxxdRbK36ESQnPUX3lWRzUJDiCwqC6HnZTSbtSpKtu5tCv70pqdUePM0wj99_HgidE3xNiEhvlGOMsgM0JjwTccpSerjzEz5CJ95_YkxpTvkxGlHSRzMixuj2DeZdrYKxbWSrSNsWIr2OwgIiVaplMCuITNN0fdivfYAmMm2kXFg4E4w_RUeVqj2cbe0EfTw-vE-f49nr08v0fhZrLkiIEwpVkSWclQKzUikQWOWi0lmaYsFTkZAs5QWuMq4LkpQl14QKBjnFOQDRCZugu4G77HQDZQFtcKqWS2ca5dbSKiP3M61ZyLldSUaJEBnvAfkA0Mb-A9jPFLaRw0373qutuLNfHfggG-MLqGvVgu28zDGnNGHpZszLobJw1nsH1U6AYLl50y_y4u8-u7Kfv7Bv6MCPGg</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Okamoto, Kazuo</creator><creator>Takayanagi, Hiroshi</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>Regulation of bone by the adaptive immune system in arthritis</title><author>Okamoto, Kazuo ; Takayanagi, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b481t-52efc7543d803daae80a98fb7660846851764c0f74bc15dd4b1283e9209ee1b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adaptive Immunity - physiology</topic><topic>Animals</topic><topic>Arthritis - immunology</topic><topic>Arthritis - metabolism</topic><topic>Bone and Bones - immunology</topic><topic>Bone and Bones - metabolism</topic><topic>Bone Diseases - immunology</topic><topic>Bone Diseases - metabolism</topic><topic>Humans</topic><topic>Osteoclasts - immunology</topic><topic>Osteoclasts - metabolism</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okamoto, Kazuo</creatorcontrib><creatorcontrib>Takayanagi, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arthritis research & therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okamoto, Kazuo</au><au>Takayanagi, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of bone by the adaptive immune system in arthritis</atitle><jtitle>Arthritis research & therapy</jtitle><addtitle>Arthritis Res Ther</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>13</volume><issue>3</issue><spage>219</spage><epage>219</epage><pages>219-219</pages><issn>1478-6354</issn><eissn>1478-6362</eissn><abstract>Studies on the immune regulation of osteoclasts in rheumatoid arthritis have promoted the new research field of 'osteoimmunology', which investigates the interplay between the skeletal and immune systems at the molecular level. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature OA Free Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Adaptive Immunity - physiology Animals Arthritis - immunology Arthritis - metabolism Bone and Bones - immunology Bone and Bones - metabolism Bone Diseases - immunology Bone Diseases - metabolism Humans Osteoclasts - immunology Osteoclasts - metabolism Review |
| title | Regulation of bone by the adaptive immune system in arthritis |
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