Sjögren's syndrome: studying the disease in mice
Sjögren's syndrome (SS), a systemic autoimmune disease, is characterized by inflammation of exocrine tissues accompanied by a significant loss of their secretory function. Clinical symptoms develop late and there are no diagnostic tests enabling early diagnosis of SS. Thus, particularly to stud...
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| Veröffentlicht in: | Arthritis research & therapy 2011-01, Vol.13 (3), p.217-217 |
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| container_title | Arthritis research & therapy |
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| creator | Delaleu, Nicolas Nguyen, Cuong Q Peck, Ammon B Jonsson, Roland |
| description | Sjögren's syndrome (SS), a systemic autoimmune disease, is characterized by inflammation of exocrine tissues accompanied by a significant loss of their secretory function. Clinical symptoms develop late and there are no diagnostic tests enabling early diagnosis of SS. Thus, particularly to study these covert stages, researchers turn to studying animal models where mice provide great freedom for genetic manipulation and testing the effect of experimental intervention. The present review summarizes current literature pertaining to both spontaneous and extrinsic-factor induced SS-like diseases in mouse models, discussing advantages and disadvantages related to the use of murine models in SS research. |
| doi_str_mv | 10.1186/ar3313 |
| format | Article |
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Clinical symptoms develop late and there are no diagnostic tests enabling early diagnosis of SS. Thus, particularly to study these covert stages, researchers turn to studying animal models where mice provide great freedom for genetic manipulation and testing the effect of experimental intervention. The present review summarizes current literature pertaining to both spontaneous and extrinsic-factor induced SS-like diseases in mouse models, discussing advantages and disadvantages related to the use of murine models in SS research.</description><identifier>ISSN: 1478-6354</identifier><identifier>EISSN: 1478-6362</identifier><identifier>DOI: 10.1186/ar3313</identifier><identifier>PMID: 21672284</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Disease Models, Animal ; Humans ; Immunogenetics - trends ; Mice ; Review ; Sjogren's Syndrome - genetics ; Sjogren's Syndrome - immunology ; Sjogren's Syndrome - therapy</subject><ispartof>Arthritis research & therapy, 2011-01, Vol.13 (3), p.217-217</ispartof><rights>Copyright ©2011 BioMed Central Ltd 2011 BioMed Central Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b415t-3dbd532a5aeab01ede23da8042cdb73747c4c4bbfd142b06e4c8ea60af2b3f713</citedby><cites>FETCH-LOGICAL-b415t-3dbd532a5aeab01ede23da8042cdb73747c4c4bbfd142b06e4c8ea60af2b3f713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218871/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218871/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21672284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delaleu, Nicolas</creatorcontrib><creatorcontrib>Nguyen, Cuong Q</creatorcontrib><creatorcontrib>Peck, Ammon B</creatorcontrib><creatorcontrib>Jonsson, Roland</creatorcontrib><title>Sjögren's syndrome: studying the disease in mice</title><title>Arthritis research & therapy</title><addtitle>Arthritis Res Ther</addtitle><description>Sjögren's syndrome (SS), a systemic autoimmune disease, is characterized by inflammation of exocrine tissues accompanied by a significant loss of their secretory function. Clinical symptoms develop late and there are no diagnostic tests enabling early diagnosis of SS. Thus, particularly to study these covert stages, researchers turn to studying animal models where mice provide great freedom for genetic manipulation and testing the effect of experimental intervention. The present review summarizes current literature pertaining to both spontaneous and extrinsic-factor induced SS-like diseases in mouse models, discussing advantages and disadvantages related to the use of murine models in SS research.</description><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Humans</subject><subject>Immunogenetics - trends</subject><subject>Mice</subject><subject>Review</subject><subject>Sjogren's Syndrome - genetics</subject><subject>Sjogren's Syndrome - immunology</subject><subject>Sjogren's Syndrome - therapy</subject><issn>1478-6354</issn><issn>1478-6362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctOwzAQRS0EoqXAJ6Cs6CrgV-yUBRKqeEmVWABry49J66pJip0g9cf4AX6MQkqBBasZae6cq5mL0DHBZ4Tk4lwHxgjbQX3CZZ4KJujuts94Dx3EOMeY0hHl-6hHiZCU5ryPyOP8_W0aoBrGJK4qF-oSLpLYtG7lq2nSzCBxPoKOkPgqKb2FQ7RX6EWEo00doOeb66fxXTp5uL0fX01Sw0nWpMwZlzGqMw3aYAIOKHM6x5xaZySTXFpuuTGFI5waLIDbHLTAuqCGFZKwAbrsuMvWlOAsVE3QC7UMvtRhpWrt1d9J5WdqWr8qRkmefwFGHcD4-h_A34mtS9X9cb073JiH-qWF2KjSRwuLha6gbqMa4UwIKXO8Vp52ShvqGAMUWwOC1Wc0P8iT3_dsZd9ZsA-YcYx-</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Delaleu, Nicolas</creator><creator>Nguyen, Cuong Q</creator><creator>Peck, Ammon B</creator><creator>Jonsson, Roland</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>Sjögren's syndrome: studying the disease in mice</title><author>Delaleu, Nicolas ; Nguyen, Cuong Q ; Peck, Ammon B ; Jonsson, Roland</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b415t-3dbd532a5aeab01ede23da8042cdb73747c4c4bbfd142b06e4c8ea60af2b3f713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Humans</topic><topic>Immunogenetics - trends</topic><topic>Mice</topic><topic>Review</topic><topic>Sjogren's Syndrome - genetics</topic><topic>Sjogren's Syndrome - immunology</topic><topic>Sjogren's Syndrome - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delaleu, Nicolas</creatorcontrib><creatorcontrib>Nguyen, Cuong Q</creatorcontrib><creatorcontrib>Peck, Ammon B</creatorcontrib><creatorcontrib>Jonsson, Roland</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arthritis research & therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delaleu, Nicolas</au><au>Nguyen, Cuong Q</au><au>Peck, Ammon B</au><au>Jonsson, Roland</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sjögren's syndrome: studying the disease in mice</atitle><jtitle>Arthritis research & therapy</jtitle><addtitle>Arthritis Res Ther</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>13</volume><issue>3</issue><spage>217</spage><epage>217</epage><pages>217-217</pages><issn>1478-6354</issn><eissn>1478-6362</eissn><abstract>Sjögren's syndrome (SS), a systemic autoimmune disease, is characterized by inflammation of exocrine tissues accompanied by a significant loss of their secretory function. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature OA Free Journals; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | Animals Disease Models, Animal Humans Immunogenetics - trends Mice Review Sjogren's Syndrome - genetics Sjogren's Syndrome - immunology Sjogren's Syndrome - therapy |
| title | Sjögren's syndrome: studying the disease in mice |
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