Src family kinases mediate epidermal growth factor receptor signaling from lipid rafts in breast cancer cells

Activation of the epidermal growth factor receptor (EGFR) regulates cellular proliferation, survival, and migration of breast cancer cells. In particular, EGFR recruits signaling proteins to the cell membrane leading to their phosphorylation and activation. However, EGFR also localizes to other cell...

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Veröffentlicht in:	Cancer biology & therapy 2011-10, Vol.12 (8), p.718-726
Hauptverfasser:	Irwin, Mary E., Bohin, Natacha, Boerner, Julie L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biology Bioscience Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - metabolism Breast Neoplasms - pathology Calcium Cancer Cell Cell Growth Processes - physiology Cell Line, Tumor Cycle Drug Synergism Female Humans Landes Membrane Microdomains - metabolism Oncogene Protein v-akt - metabolism Organogenesis Phosphorylation Protein Kinase Inhibitors - pharmacology Proteins Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Research Paper Signal Transduction src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism
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