α-ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition

Cells must coordinate nutrient uptake for balanced growth, but the mechanism by which this occurs was unknown. Flux measurements and biochemical assays now identify α-ketoglutarate as the key signal in this process that accumulates upon nitrogen limitation and inhibits an enzyme involved in glucose...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature chemical biology 2011-10, Vol.7 (12), p.894-901
Hauptverfasser:	Doucette, Christopher D, Schwab, David J, Wingreen, Ned S, Rabinowitz, Joshua D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/41/1969 631/443/319 631/92/320 Biochemical Engineering Biochemistry Biomass Bioorganic Chemistry Carbon - chemistry Carbon - metabolism Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Escherichia coli - enzymology Escherichia coli - growth & development Escherichia coli - metabolism Glucose - antagonists & inhibitors Glucose - metabolism Ketoglutaric Acids - chemistry Ketoglutaric Acids - pharmacology Nitrogen - chemistry Nitrogen - metabolism Phosphoenolpyruvate Sugar Phosphotransferase System - antagonists & inhibitors Phosphoenolpyruvate Sugar Phosphotransferase System - metabolism Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!