Do Aspirin and Other Antiplatelet Drugs Reduce the Mortality in Critically Ill Patients?

Do Aspirin and Other Antiplatelet Drugs Reduce the Mortality in Critically Ill Patients?

Platelet activation has been implicated in microvascular thrombosis and organ failure in critically ill patients. In the first part the present paper summarises important data on the role of platelets in systemic inflammation and sepsis as well as on the beneficial effects of antiplatelet drugs in a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Thrombosis 2012, Vol.2012 (2012), p.234-241
Hauptverfasser: Boettel, Janina, Lösche, Wolfgang, Kabisch, Björn, Winning, Johannes, Claus, Ralf A., Bauer, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Review
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 241
container_issue 2012
container_start_page 234
container_title Thrombosis
container_volume 2012
creator Boettel, Janina
Lösche, Wolfgang
Kabisch, Björn
Winning, Johannes
Claus, Ralf A.
Bauer, Michael
description Platelet activation has been implicated in microvascular thrombosis and organ failure in critically ill patients. In the first part the present paper summarises important data on the role of platelets in systemic inflammation and sepsis as well as on the beneficial effects of antiplatelet drugs in animal models of sepsis. In the second part the data of retrospective and prospective observational clinical studies on the effect of aspirin and other antiplatelet drugs in critically ill patients are reviewed. All of these studies have shown that aspirin and other antiplatelet drugs may reduce organ failure and mortality in these patients, even in case of high bleeding risk. From the data reviewed here interventional prospective trials are needed to test whether aspirin and other antiplatelet drugs might offer a novel therapeutic option to prevent organ failure in critically ill patients.
doi_str_mv 10.1155/2012/720254
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3216368</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><airiti_id>P20150731002_201212_201710200005_201710200005_234_241</airiti_id><sourcerecordid>905963974</sourcerecordid><originalsourceid>FETCH-LOGICAL-a3514-295ffb77c06a2efae3af3bb4cae4674ea32406a271fd2d97fe6340394ebb92b63</originalsourceid><addsrcrecordid>eNqFks1rFDEYxoMotqw9eVZyE5Rt853NRVm21RZWWkTBW8jMvNNNyc6sSUbZ_77Znbq0XkwOSXh-ed7wPkHoNSWnlEp5xghlZ5oRJsUzdMyIIVMqjHp-2M9mR-gkpTtShiRSKPkSHTFGKTFUHqOf5z2ep42PvsOua_B1XkHE8y77TXAZAmR8HofbhL9BM9SAi4y_9jG74PMWl0uL6LOvXQhbfBUCvnHZQ5fTp1foRetCgpOHdYJ-fL74vricLq-_XC3my6njkoopM7JtK61rohyD1gF3La8qUTsQSgtwnImdpGnbsMboFhQXhBsBVWVYpfgEfRx9N0O1hqYuxaMLdhP92sWt7Z23T5XOr-xt_9tyRhVXs2Lw7sEg9r8GSNmufaohBNdBPyRriDSKGy0K-WEk69inFKE9VKHE7tKwuzTsmEah3z5-2IH92_sCvB-Ble8a98f_x-3NCENBSp8OsDCclTlBy1F3fheIveuH2JW-25viIonmlBC2d6T7RVPC9l_inwMXlgnK7wHeqK_s</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>905963974</pqid></control><display><type>article</type><title>Do Aspirin and Other Antiplatelet Drugs Reduce the Mortality in Critically Ill Patients?</title><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Boettel, Janina ; Lösche, Wolfgang ; Kabisch, Björn ; Winning, Johannes ; Claus, Ralf A. ; Bauer, Michael</creator><contributor>Walenga, Jeanine M.</contributor><creatorcontrib>Boettel, Janina ; Lösche, Wolfgang ; Kabisch, Björn ; Winning, Johannes ; Claus, Ralf A. ; Bauer, Michael ; Walenga, Jeanine M.</creatorcontrib><description>Platelet activation has been implicated in microvascular thrombosis and organ failure in critically ill patients. In the first part the present paper summarises important data on the role of platelets in systemic inflammation and sepsis as well as on the beneficial effects of antiplatelet drugs in animal models of sepsis. In the second part the data of retrospective and prospective observational clinical studies on the effect of aspirin and other antiplatelet drugs in critically ill patients are reviewed. All of these studies have shown that aspirin and other antiplatelet drugs may reduce organ failure and mortality in these patients, even in case of high bleeding risk. From the data reviewed here interventional prospective trials are needed to test whether aspirin and other antiplatelet drugs might offer a novel therapeutic option to prevent organ failure in critically ill patients.</description><identifier>ISSN: 2090-1488</identifier><identifier>EISSN: 2090-1496</identifier><identifier>DOI: 10.1155/2012/720254</identifier><identifier>PMID: 22110915</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><subject>Review</subject><ispartof>Thrombosis, 2012, Vol.2012 (2012), p.234-241</ispartof><rights>Copyright © 2012 Wolfgang Lösche et al.</rights><rights>Copyright © 2012 Wolfgang Lösche et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a3514-295ffb77c06a2efae3af3bb4cae4674ea32406a271fd2d97fe6340394ebb92b63</citedby><cites>FETCH-LOGICAL-a3514-295ffb77c06a2efae3af3bb4cae4674ea32406a271fd2d97fe6340394ebb92b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216368/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216368/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22110915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Walenga, Jeanine M.</contributor><creatorcontrib>Boettel, Janina</creatorcontrib><creatorcontrib>Lösche, Wolfgang</creatorcontrib><creatorcontrib>Kabisch, Björn</creatorcontrib><creatorcontrib>Winning, Johannes</creatorcontrib><creatorcontrib>Claus, Ralf A.</creatorcontrib><creatorcontrib>Bauer, Michael</creatorcontrib><title>Do Aspirin and Other Antiplatelet Drugs Reduce the Mortality in Critically Ill Patients?</title><title>Thrombosis</title><addtitle>Thrombosis</addtitle><description>Platelet activation has been implicated in microvascular thrombosis and organ failure in critically ill patients. In the first part the present paper summarises important data on the role of platelets in systemic inflammation and sepsis as well as on the beneficial effects of antiplatelet drugs in animal models of sepsis. In the second part the data of retrospective and prospective observational clinical studies on the effect of aspirin and other antiplatelet drugs in critically ill patients are reviewed. All of these studies have shown that aspirin and other antiplatelet drugs may reduce organ failure and mortality in these patients, even in case of high bleeding risk. From the data reviewed here interventional prospective trials are needed to test whether aspirin and other antiplatelet drugs might offer a novel therapeutic option to prevent organ failure in critically ill patients.</description><subject>Review</subject><issn>2090-1488</issn><issn>2090-1496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><recordid>eNqFks1rFDEYxoMotqw9eVZyE5Rt853NRVm21RZWWkTBW8jMvNNNyc6sSUbZ_77Znbq0XkwOSXh-ed7wPkHoNSWnlEp5xghlZ5oRJsUzdMyIIVMqjHp-2M9mR-gkpTtShiRSKPkSHTFGKTFUHqOf5z2ep42PvsOua_B1XkHE8y77TXAZAmR8HofbhL9BM9SAi4y_9jG74PMWl0uL6LOvXQhbfBUCvnHZQ5fTp1foRetCgpOHdYJ-fL74vricLq-_XC3my6njkoopM7JtK61rohyD1gF3La8qUTsQSgtwnImdpGnbsMboFhQXhBsBVWVYpfgEfRx9N0O1hqYuxaMLdhP92sWt7Z23T5XOr-xt_9tyRhVXs2Lw7sEg9r8GSNmufaohBNdBPyRriDSKGy0K-WEk69inFKE9VKHE7tKwuzTsmEah3z5-2IH92_sCvB-Ble8a98f_x-3NCENBSp8OsDCclTlBy1F3fheIveuH2JW-25viIonmlBC2d6T7RVPC9l_inwMXlgnK7wHeqK_s</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Boettel, Janina</creator><creator>Lösche, Wolfgang</creator><creator>Kabisch, Björn</creator><creator>Winning, Johannes</creator><creator>Claus, Ralf A.</creator><creator>Bauer, Michael</creator><general>Hindawi Limiteds</general><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><scope>188</scope><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2012</creationdate><title>Do Aspirin and Other Antiplatelet Drugs Reduce the Mortality in Critically Ill Patients?</title><author>Boettel, Janina ; Lösche, Wolfgang ; Kabisch, Björn ; Winning, Johannes ; Claus, Ralf A. ; Bauer, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a3514-295ffb77c06a2efae3af3bb4cae4674ea32406a271fd2d97fe6340394ebb92b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boettel, Janina</creatorcontrib><creatorcontrib>Lösche, Wolfgang</creatorcontrib><creatorcontrib>Kabisch, Björn</creatorcontrib><creatorcontrib>Winning, Johannes</creatorcontrib><creatorcontrib>Claus, Ralf A.</creatorcontrib><creatorcontrib>Bauer, Michael</creatorcontrib><collection>Airiti Library</collection><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Thrombosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boettel, Janina</au><au>Lösche, Wolfgang</au><au>Kabisch, Björn</au><au>Winning, Johannes</au><au>Claus, Ralf A.</au><au>Bauer, Michael</au><au>Walenga, Jeanine M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do Aspirin and Other Antiplatelet Drugs Reduce the Mortality in Critically Ill Patients?</atitle><jtitle>Thrombosis</jtitle><addtitle>Thrombosis</addtitle><date>2012</date><risdate>2012</risdate><volume>2012</volume><issue>2012</issue><spage>234</spage><epage>241</epage><pages>234-241</pages><issn>2090-1488</issn><eissn>2090-1496</eissn><abstract>Platelet activation has been implicated in microvascular thrombosis and organ failure in critically ill patients. In the first part the present paper summarises important data on the role of platelets in systemic inflammation and sepsis as well as on the beneficial effects of antiplatelet drugs in animal models of sepsis. In the second part the data of retrospective and prospective observational clinical studies on the effect of aspirin and other antiplatelet drugs in critically ill patients are reviewed. All of these studies have shown that aspirin and other antiplatelet drugs may reduce organ failure and mortality in these patients, even in case of high bleeding risk. From the data reviewed here interventional prospective trials are needed to test whether aspirin and other antiplatelet drugs might offer a novel therapeutic option to prevent organ failure in critically ill patients.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Limiteds</pub><pmid>22110915</pmid><doi>10.1155/2012/720254</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2090-1488
ispartof Thrombosis, 2012, Vol.2012 (2012), p.234-241
issn 2090-1488
2090-1496
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3216368
source Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access
subjects Review
title Do Aspirin and Other Antiplatelet Drugs Reduce the Mortality in Critically Ill Patients?
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T02%3A12%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Do%20Aspirin%20and%20Other%20Antiplatelet%20Drugs%20Reduce%20the%20Mortality%20in%20Critically%20Ill%20Patients?&rft.jtitle=Thrombosis&rft.au=Boettel,%20Janina&rft.date=2012&rft.volume=2012&rft.issue=2012&rft.spage=234&rft.epage=241&rft.pages=234-241&rft.issn=2090-1488&rft.eissn=2090-1496&rft_id=info:doi/10.1155/2012/720254&rft_dat=%3Cproquest_pubme%3E905963974%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=905963974&rft_id=info:pmid/22110915&rft_airiti_id=P20150731002_201212_201710200005_201710200005_234_241&rfr_iscdi=true