Comparison of breast density measured on MR images acquired using fat-suppressed versus nonfat-suppressed sequences
Purpose: To investigate the difference of MR percent breast density measured from fat-suppressed versus nonfat-suppressed imaging sequences. Methods: Breast magnetic resonance imaging (MRI) with and without fat suppression was acquired from 38 subjects. Breasts were divided into subgroups of differe...
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| Veröffentlicht in: | Medical physics (Lancaster) 2011-11, Vol.38 (11), p.5961-5968 |
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| creator | Chang, Daniel H.-E. Chen, Jeon-Hor Lin, Muqing Bahri, Shadfar Yu, Hon J. Mehta, Rita S. Nie, Ke Hsiang, David J. B. Nalcioglu, Orhan Su, Min-Ying |
| description | Purpose:
To investigate the difference of MR percent breast density measured from fat-suppressed versus nonfat-suppressed imaging sequences.
Methods:
Breast magnetic resonance imaging (MRI) with and without fat suppression was acquired from 38 subjects. Breasts were divided into subgroups of different morphological patterns ("central" and "intermingled" types). Breast volume, fibroglandular tissue volume, and percent density were measured. The results were compared using nonparametric statistical tests and regarded as significant at p |
| doi_str_mv | 10.1118/1.3646756 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3215688</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>902344430</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4676-88dddf73997a2cccd2dee12692e6bda5d9a2d9f9562780fd52e8f68094ce91953</originalsourceid><addsrcrecordid>eNp1kUtv1DAUhS0EokNhwR9A3iEWKX4kTrxBQqNCkVqBEKwtj30zGCV26pu0mn-PqwnlIXVl-Z7Px_foEPKSszPOefeWn0lVq7ZRj8hG1K2sasH0Y7JhTNeVqFlzQp4h_mSMKdmwp-RECFYwxTYEt2mcbA6YIk093WWwOFMPEcN8oGO5LRk8LerVVxpGuwek1l0v4W66YIh72tu5wmWaMiCW4Q1kXJDGFP8TEK4XiA7wOXnS2wHhxXqeku8fzr9tL6rLzx8_bd9fVq6EUVXXee_7VmrdWuGc88IDcKG0ALXztvHaCq973SjRdqz3jYCuV13J7EBz3chT8u7oOy27EbyDOGc7mCmXHPlgkg3mXyWGH2afbowUvFFdVwxerwY5ld1xNmNAB8NgI6QFjWZC1nUtWSHfHEmXE2KG_v4XzsxdR4abtaPCvvp7rXvydykFqI7AbRjg8LCTufqyGq450YXZziHFh9_8qduk3hzrlr8AGSmzHg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>902344430</pqid></control><display><type>article</type><title>Comparison of breast density measured on MR images acquired using fat-suppressed versus nonfat-suppressed sequences</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Chang, Daniel H.-E. ; Chen, Jeon-Hor ; Lin, Muqing ; Bahri, Shadfar ; Yu, Hon J. ; Mehta, Rita S. ; Nie, Ke ; Hsiang, David J. B. ; Nalcioglu, Orhan ; Su, Min-Ying</creator><creatorcontrib>Chang, Daniel H.-E. ; Chen, Jeon-Hor ; Lin, Muqing ; Bahri, Shadfar ; Yu, Hon J. ; Mehta, Rita S. ; Nie, Ke ; Hsiang, David J. B. ; Nalcioglu, Orhan ; Su, Min-Ying</creatorcontrib><description>Purpose:
To investigate the difference of MR percent breast density measured from fat-suppressed versus nonfat-suppressed imaging sequences.
Methods:
Breast magnetic resonance imaging (MRI) with and without fat suppression was acquired from 38 subjects. Breasts were divided into subgroups of different morphological patterns ("central" and "intermingled" types). Breast volume, fibroglandular tissue volume, and percent density were measured. The results were compared using nonparametric statistical tests and regarded as significant at p<0.05.
Results:
Breast volume, fibroglandular volume, and percent density between fat-suppressed and nonfat-suppressed sequences were highly correlated. Breast volumes measured on these two sequences were almost identical. Fibroglandular tissue volume and percent density, however, had small (<5%) yet significant differences between the two sequences-they were both higher on the fat-suppressed sequence. Intraobserver variability was within 4% for both sequences and different morphological types. The fibroglandular tissue volume measured on downsampled images showed a small (<5%) yet significant difference.
Conclusions:
The measurement of breast density made on MRI acquired using fat-suppressed and nonfat-suppressed T1W images was about 5% difference, only slightly higher than the intraobserver variability of 3%-4%. When the density data from multiple centers were to be combined, evaluating the degree of difference is needed to take this difference into account.</description><identifier>ISSN: 0094-2405</identifier><identifier>EISSN: 2473-4209</identifier><identifier>EISSN: 0094-2405</identifier><identifier>DOI: 10.1118/1.3646756</identifier><identifier>PMID: 22047360</identifier><identifier>CODEN: MPHYA6</identifier><language>eng</language><publisher>United States: American Association of Physicists in Medicine</publisher><subject>3D breast parenchymal morphology ; Adipose Tissue - cytology ; Adult ; Aged ; Aged, 80 and over ; biological organs ; biological tissues ; biomedical MRI ; Breast - cytology ; density measurement ; fat suppression ; Female ; gynaecology ; Humans ; Image analysis ; Image Processing, Computer-Assisted - methods ; image sequences ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Mammography ; medical image processing ; Medical image segmentation ; Medical image spatial resolution ; Medical imaging ; Middle Aged ; Observer Variation ; pulse sequence comparison ; quantitative breast density ; Sequence analysis ; Spatial resolution ; statistical analysis ; Tissue Measurements ; Tissues ; volume measurement</subject><ispartof>Medical physics (Lancaster), 2011-11, Vol.38 (11), p.5961-5968</ispartof><rights>2011 American Association of Physicists in Medicine</rights><rights>Copyright © 2011 American Association of Physicists in Medicine 2011 American Association of Physicists in Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4676-88dddf73997a2cccd2dee12692e6bda5d9a2d9f9562780fd52e8f68094ce91953</citedby><cites>FETCH-LOGICAL-c4676-88dddf73997a2cccd2dee12692e6bda5d9a2d9f9562780fd52e8f68094ce91953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1118%2F1.3646756$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1118%2F1.3646756$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22047360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Daniel H.-E.</creatorcontrib><creatorcontrib>Chen, Jeon-Hor</creatorcontrib><creatorcontrib>Lin, Muqing</creatorcontrib><creatorcontrib>Bahri, Shadfar</creatorcontrib><creatorcontrib>Yu, Hon J.</creatorcontrib><creatorcontrib>Mehta, Rita S.</creatorcontrib><creatorcontrib>Nie, Ke</creatorcontrib><creatorcontrib>Hsiang, David J. B.</creatorcontrib><creatorcontrib>Nalcioglu, Orhan</creatorcontrib><creatorcontrib>Su, Min-Ying</creatorcontrib><title>Comparison of breast density measured on MR images acquired using fat-suppressed versus nonfat-suppressed sequences</title><title>Medical physics (Lancaster)</title><addtitle>Med Phys</addtitle><description>Purpose:
To investigate the difference of MR percent breast density measured from fat-suppressed versus nonfat-suppressed imaging sequences.
Methods:
Breast magnetic resonance imaging (MRI) with and without fat suppression was acquired from 38 subjects. Breasts were divided into subgroups of different morphological patterns ("central" and "intermingled" types). Breast volume, fibroglandular tissue volume, and percent density were measured. The results were compared using nonparametric statistical tests and regarded as significant at p<0.05.
Results:
Breast volume, fibroglandular volume, and percent density between fat-suppressed and nonfat-suppressed sequences were highly correlated. Breast volumes measured on these two sequences were almost identical. Fibroglandular tissue volume and percent density, however, had small (<5%) yet significant differences between the two sequences-they were both higher on the fat-suppressed sequence. Intraobserver variability was within 4% for both sequences and different morphological types. The fibroglandular tissue volume measured on downsampled images showed a small (<5%) yet significant difference.
Conclusions:
The measurement of breast density made on MRI acquired using fat-suppressed and nonfat-suppressed T1W images was about 5% difference, only slightly higher than the intraobserver variability of 3%-4%. When the density data from multiple centers were to be combined, evaluating the degree of difference is needed to take this difference into account.</description><subject>3D breast parenchymal morphology</subject><subject>Adipose Tissue - cytology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>biological organs</subject><subject>biological tissues</subject><subject>biomedical MRI</subject><subject>Breast - cytology</subject><subject>density measurement</subject><subject>fat suppression</subject><subject>Female</subject><subject>gynaecology</subject><subject>Humans</subject><subject>Image analysis</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>image sequences</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Mammography</subject><subject>medical image processing</subject><subject>Medical image segmentation</subject><subject>Medical image spatial resolution</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Observer Variation</subject><subject>pulse sequence comparison</subject><subject>quantitative breast density</subject><subject>Sequence analysis</subject><subject>Spatial resolution</subject><subject>statistical analysis</subject><subject>Tissue Measurements</subject><subject>Tissues</subject><subject>volume measurement</subject><issn>0094-2405</issn><issn>2473-4209</issn><issn>0094-2405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtv1DAUhS0EokNhwR9A3iEWKX4kTrxBQqNCkVqBEKwtj30zGCV26pu0mn-PqwnlIXVl-Z7Px_foEPKSszPOefeWn0lVq7ZRj8hG1K2sasH0Y7JhTNeVqFlzQp4h_mSMKdmwp-RECFYwxTYEt2mcbA6YIk093WWwOFMPEcN8oGO5LRk8LerVVxpGuwek1l0v4W66YIh72tu5wmWaMiCW4Q1kXJDGFP8TEK4XiA7wOXnS2wHhxXqeku8fzr9tL6rLzx8_bd9fVq6EUVXXee_7VmrdWuGc88IDcKG0ALXztvHaCq973SjRdqz3jYCuV13J7EBz3chT8u7oOy27EbyDOGc7mCmXHPlgkg3mXyWGH2afbowUvFFdVwxerwY5ld1xNmNAB8NgI6QFjWZC1nUtWSHfHEmXE2KG_v4XzsxdR4abtaPCvvp7rXvydykFqI7AbRjg8LCTufqyGq450YXZziHFh9_8qduk3hzrlr8AGSmzHg</recordid><startdate>201111</startdate><enddate>201111</enddate><creator>Chang, Daniel H.-E.</creator><creator>Chen, Jeon-Hor</creator><creator>Lin, Muqing</creator><creator>Bahri, Shadfar</creator><creator>Yu, Hon J.</creator><creator>Mehta, Rita S.</creator><creator>Nie, Ke</creator><creator>Hsiang, David J. B.</creator><creator>Nalcioglu, Orhan</creator><creator>Su, Min-Ying</creator><general>American Association of Physicists in Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201111</creationdate><title>Comparison of breast density measured on MR images acquired using fat-suppressed versus nonfat-suppressed sequences</title><author>Chang, Daniel H.-E. ; Chen, Jeon-Hor ; Lin, Muqing ; Bahri, Shadfar ; Yu, Hon J. ; Mehta, Rita S. ; Nie, Ke ; Hsiang, David J. B. ; Nalcioglu, Orhan ; Su, Min-Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4676-88dddf73997a2cccd2dee12692e6bda5d9a2d9f9562780fd52e8f68094ce91953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>3D breast parenchymal morphology</topic><topic>Adipose Tissue - cytology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>biological organs</topic><topic>biological tissues</topic><topic>biomedical MRI</topic><topic>Breast - cytology</topic><topic>density measurement</topic><topic>fat suppression</topic><topic>Female</topic><topic>gynaecology</topic><topic>Humans</topic><topic>Image analysis</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>image sequences</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Mammography</topic><topic>medical image processing</topic><topic>Medical image segmentation</topic><topic>Medical image spatial resolution</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Observer Variation</topic><topic>pulse sequence comparison</topic><topic>quantitative breast density</topic><topic>Sequence analysis</topic><topic>Spatial resolution</topic><topic>statistical analysis</topic><topic>Tissue Measurements</topic><topic>Tissues</topic><topic>volume measurement</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Daniel H.-E.</creatorcontrib><creatorcontrib>Chen, Jeon-Hor</creatorcontrib><creatorcontrib>Lin, Muqing</creatorcontrib><creatorcontrib>Bahri, Shadfar</creatorcontrib><creatorcontrib>Yu, Hon J.</creatorcontrib><creatorcontrib>Mehta, Rita S.</creatorcontrib><creatorcontrib>Nie, Ke</creatorcontrib><creatorcontrib>Hsiang, David J. B.</creatorcontrib><creatorcontrib>Nalcioglu, Orhan</creatorcontrib><creatorcontrib>Su, Min-Ying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Daniel H.-E.</au><au>Chen, Jeon-Hor</au><au>Lin, Muqing</au><au>Bahri, Shadfar</au><au>Yu, Hon J.</au><au>Mehta, Rita S.</au><au>Nie, Ke</au><au>Hsiang, David J. B.</au><au>Nalcioglu, Orhan</au><au>Su, Min-Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of breast density measured on MR images acquired using fat-suppressed versus nonfat-suppressed sequences</atitle><jtitle>Medical physics (Lancaster)</jtitle><addtitle>Med Phys</addtitle><date>2011-11</date><risdate>2011</risdate><volume>38</volume><issue>11</issue><spage>5961</spage><epage>5968</epage><pages>5961-5968</pages><issn>0094-2405</issn><eissn>2473-4209</eissn><eissn>0094-2405</eissn><coden>MPHYA6</coden><abstract>Purpose:
To investigate the difference of MR percent breast density measured from fat-suppressed versus nonfat-suppressed imaging sequences.
Methods:
Breast magnetic resonance imaging (MRI) with and without fat suppression was acquired from 38 subjects. Breasts were divided into subgroups of different morphological patterns ("central" and "intermingled" types). Breast volume, fibroglandular tissue volume, and percent density were measured. The results were compared using nonparametric statistical tests and regarded as significant at p<0.05.
Results:
Breast volume, fibroglandular volume, and percent density between fat-suppressed and nonfat-suppressed sequences were highly correlated. Breast volumes measured on these two sequences were almost identical. Fibroglandular tissue volume and percent density, however, had small (<5%) yet significant differences between the two sequences-they were both higher on the fat-suppressed sequence. Intraobserver variability was within 4% for both sequences and different morphological types. The fibroglandular tissue volume measured on downsampled images showed a small (<5%) yet significant difference.
Conclusions:
The measurement of breast density made on MRI acquired using fat-suppressed and nonfat-suppressed T1W images was about 5% difference, only slightly higher than the intraobserver variability of 3%-4%. When the density data from multiple centers were to be combined, evaluating the degree of difference is needed to take this difference into account.</abstract><cop>United States</cop><pub>American Association of Physicists in Medicine</pub><pmid>22047360</pmid><doi>10.1118/1.3646756</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3D breast parenchymal morphology Adipose Tissue - cytology Adult Aged Aged, 80 and over biological organs biological tissues biomedical MRI Breast - cytology density measurement fat suppression Female gynaecology Humans Image analysis Image Processing, Computer-Assisted - methods image sequences Magnetic resonance imaging Magnetic Resonance Imaging - methods Mammography medical image processing Medical image segmentation Medical image spatial resolution Medical imaging Middle Aged Observer Variation pulse sequence comparison quantitative breast density Sequence analysis Spatial resolution statistical analysis Tissue Measurements Tissues volume measurement |
| title | Comparison of breast density measured on MR images acquired using fat-suppressed versus nonfat-suppressed sequences |
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