Absolute requirement for STAT3 function in small-intestine crypt stem cell survival

The transcription factor signal transducer and activator of transcription 3 (STAT3) is frequently activated in human cancers. Interestingly, STAT3 also maintains the pluripotency and self-renewal of murine embryonic stem cells, and several tissue stem cell types. To investigate whether STAT3 also ma...

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Veröffentlicht in:	Cell death and differentiation 2011-12, Vol.18 (12), p.1934-1943
Hauptverfasser:	Matthews, J R, Sansom, O J, Clarke, A R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612/822 631/532/2118/2437 Animals Apoptosis Biochemistry Biomedical and Life Sciences Cancer Caspase 3 - metabolism Cell Biology Cell cycle Cell Cycle Analysis Cell death Cell Movement Cell Proliferation Cell Survival Enzyme Activation Gene Expression Intestinal Mucosa - cytology Intestinal Mucosa - metabolism Intestine, Small - cytology Intestine, Small - metabolism Kinases Life Sciences Male Mice Mice, 129 Strain Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Nuclear Proteins - metabolism Original Paper Pathophysiology Polycomb Repressive Complex 1 Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Repressor Proteins - metabolism STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism STAT3 Transcription Factor - physiology Stem Cells Stem Cells - metabolism Stem Cells - physiology Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Up-Regulation
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