Nitric oxide synthase 3 deficiency limits adverse ventricular remodeling after pressure overload in insulin resistance

Insulin resistance (IR) and systemic hypertension are independently associated with heart failure. We reported previously that nitric oxide synthase 3 (NOS3) has a beneficial effect on left ventricular (LV) remodeling and function after pressure-overload in mice. The aim of our study was to investig...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2011-11, Vol.301 (5), p.H2093-H2101
Hauptverfasser:	Kurtz, Baptiste, Thibault, Helene B, Raher, Michael J, Popovich, John R, Cawley, Sharon, Atochin, Dmitriy N, Hayton, Sarah, Shakartzi, Hannah R, Huang, Paul L, Bloch, Kenneth D, Buys, Emmanuel, Scherrer-Crosbie, Marielle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Cardiomyocytes Dietary Fats - administration & dosage Disease Models, Animal Energy Metabolism Enzyme Inhibitors - pharmacology Gene Expression Regulation, Enzymologic Heart failure Heart Failure - enzymology Heart Failure - etiology Heart Failure - genetics Heart Failure - physiopathology Hydrogen Peroxide - metabolism Hypertension - complications Hypertension - diagnostic imaging Hypertension - enzymology Hypertension - genetics Hypertension - physiopathology Insulin resistance Insulin Resistance - genetics Integrative Cardiovascular Physiology and Pathophysiology Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria, Heart - enzymology Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Myocytes, Cardiac - pathology Nitric oxide Nitric Oxide Synthase Type III - antagonists & inhibitors Nitric Oxide Synthase Type III - deficiency Nitric Oxide Synthase Type III - genetics Oxidative Stress Phosphorylation Rodents Serine Time Factors Ultrasonography Uncoupling Agents - pharmacology Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - enzymology Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - genetics Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left - drug effects Ventricular Remodeling - drug effects
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