Fetal growth restriction and the programming of heart growth and cardiac insulin‐like growth factor 2 expression in the lamb

Non‐Technical Summary Cardiovascular disease is responsible for 30% of deaths worldwide and epidemiological data demonstrate that poor growth before birth is associated with an increased risk of heart disease in adult life. We show that in response to reduced placental substrate supply there is an...

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Veröffentlicht in:	The Journal of physiology 2011-10, Vol.589 (19), p.4709-4722
Hauptverfasser:	Wang, Kimberley C. W., Zhang, Lei, McMillen, I. Caroline, Botting, Kimberley J., Duffield, Jaime A., Zhang, Song, Suter, Catherine M., Brooks, Doug A., Morrison, Janna L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Birth weight Cardiomegaly - genetics Cardiomegaly - metabolism Cardiovascular Cardiovascular disease DNA Methylation Fetal Growth Retardation - genetics Fetal Growth Retardation - metabolism Fetus - embryology Fetus - metabolism Fetuses Gene expression Gene Expression - genetics Heart Heart - embryology Heart - growth & development Heart Ventricles - embryology Heart Ventricles - growth & development Heart Ventricles - metabolism Insulin Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor II - biosynthesis Insulin-Like Growth Factor II - genetics Insulin-Like Growth Factor II - metabolism Insulin-like growth factors Myocardium - metabolism Myocytes, Cardiac - metabolism Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism Receptor, IGF Type 2 - genetics Receptor, IGF Type 2 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Sheep Signal Transduction
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