Therapeutic siRNA silencing in inflammatory monocytes

Inflammatory monocytes -- but not the non-inflammatory subset -- depend on the chemokine receptor CCR2 for distribution to injured tissue and stimulate disease progression. Precise therapeutic targeting of this inflammatory monocyte subset could spare innate immunity's essential functions for m...

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Veröffentlicht in:	Nature biotechnology 2011-10, Vol.29 (11), p.1005-1010
Hauptverfasser:	Leuschner, Florian, Dutta, Partha, Gorbatov, Rostic, Novobrantseva, Tatiana I., Sullivan, Jessica, Courties, Gabriel, Lee, Kang Mi, Kim, James I., Markmann, James F., Marinelli, Brett, Panizzi, Peter, Lee, Won Woo, Iwamoto, Yoshiko, Milstein, Stuart, Epstein-Barash, Hila, Cantley, William, Wong, Jamie, Cortez-Retamozo, Virna, Newton, Andita, Love, Kevin, Libby, Peter, Pittet, Mikael J., Swirski, Filip K., Koteliansky, Victor, Langer, Robert, Weissleder, Ralph, Anderson, Daniel G., Nahrendorf, Matthias
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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