Pharmacologic Development of Male Hormonal Contraceptive Agents

The world population continues to increase dramatically despite the existence of contraceptive technology. The use of male hormonal contraception may help in preventing unintended pregnancies and managing future population growth. Male hormonal contraception relies on the administration of exogenous hormones to suppress spermatogenesis. Clinical trials have tested several regimens using testosterone, alone or in combination with a progestin. These regimens were shown to be >90% effective in preventing conception and were not associated with serious adverse events. Clinical Pharmacology & Therapeutics (2011) 89 1, 133–136. doi: 10.1038/clpt.2010.103