Aniline-induced nitrosative stress in rat spleen: Proteomic identification of nitrated proteins

Aniline exposure is associated with toxicity to the spleen which is characterized by splenomegaly, hyperplasia, fibrosis, and a variety of sarcomas on chronic exposure in rats. However, mechanisms by which aniline elicits splenotoxic responses are not well understood. Earlier we have shown that anil...

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Veröffentlicht in:	Toxicology and applied pharmacology 2011-08, Vol.255 (1), p.103-112
Hauptverfasser:	Fan, Xiuzhen, Wang, Jianling, Soman, Kizhake V., Ansari, G.A.S., Khan, M. Firoze
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACTIN ALDEHYDES AMINES AMINO ACIDS ANILINE Aniline Compounds - toxicity ANIMALS AROMATICS Biological and medical sciences Blotting, Western BODY CARBOXYLIC ACIDS CHALCOGENIDES CONTROL DESORPTION DISEASES ELEMENTS ENZYMES HYDROXY ACIDS Male MAMMALS MASS SPECTROSCOPY Medical sciences MESSENGER-RNA NEOPLASMS Nitrated proteins NITRIC OXIDE Nitric Oxide Synthase Type II - genetics NITROGEN NITROGEN COMPOUNDS NITROGEN OXIDES NONMETALS NUCLEIC ACIDS ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS OXIDES OXYGEN COMPOUNDS PATHOLOGICAL CHANGES PEPTIDES PROTEINS Proteins - metabolism Proteomics RATS Rats, Sprague-Dawley Reactive nitrogen species RNA RODENTS SARCOMAS SORPTION SPECTROSCOPY SPLEEN Spleen - drug effects Spleen - metabolism Splenic toxicity SPLENOMEGALY Stress, Physiological SYMPTOMS SYNTHESIS TIME-OF-FLIGHT METHOD TOXICITY Toxicology TYROSINE VERTEBRATES
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