Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells

Although the pivotal role of platelet derived growth factor (PDGF)‐mediated signaling in vascular diseases was demonstrated, the pathophysiological mechanisms driving its over‐activation remain incompletely understood. Tissue transglutaminase (tTG) is a multifunctional protein expressed in the vascu...

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Veröffentlicht in:	Journal of cellular physiology 2012-05, Vol.227 (5), p.2089-2096
Hauptverfasser:	Zemskov, Evgeny A., Mikhailenko, Irina, Smith, Elizabeth P., Belkin, Alexey M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement Cell Proliferation Cell Survival Humans Male Mice Mice, Inbred C57BL Muscle, Smooth, Vascular - cytology Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - metabolism Proto-Oncogene Proteins c-sis - genetics Proto-Oncogene Proteins c-sis - metabolism Receptor, Platelet-Derived Growth Factor alpha - genetics Receptor, Platelet-Derived Growth Factor alpha - metabolism Receptor, Platelet-Derived Growth Factor beta - genetics Receptor, Platelet-Derived Growth Factor beta - metabolism Signal Transduction - physiology Transglutaminases - metabolism
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