Galanthamine plus estradiol treatment enhances cognitive performance in aged ovariectomized rats

We hypothesize that beneficial effects of estradiol on cognitive performance diminish with age and time following menopause due to a progressive decline in basal forebrain cholinergic function. This study tested whether galanthamine, a cholinesterase inhibitor used to treat memory impairment associa...

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Veröffentlicht in:	Hormones and behavior 2011-11, Vol.60 (5), p.607-616
Hauptverfasser:	Gibbs, R.B., Chipman, A.M., Hammond, R., Nelson, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine - secretion Adult and adolescent clinical studies Alzheimer's disease Animal cognition Animal memory Animals Behavioral psychophysiology Biological and medical sciences Choline O-Acetyltransferase - metabolism Cholinesterase inhibitor Cholinesterase Inhibitors - pharmacology Cognition - drug effects Cognitive aging Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drug Therapy, Combination Estradiol - pharmacology Female Fundamental and applied biological sciences. Psychology Galantamine - pharmacology Hippocampus - drug effects Hippocampus - enzymology Hippocampus - secretion Hormone replacement therapy Hormone therapy Hormones Hormones and behavior Maze Learning - drug effects Medical sciences Neurology Nicotinic receptors Organic mental disorders. Neuropsychology Ovariectomy Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Rats Rats, Sprague-Dawley Rodents Spatial learning Surgical menopause
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