Biochemical Effects of Lead Exposure on Systolic & Diastolic Blood Pressure, Heme Biosynthesis and Hematological Parameters in Automobile Workers of North Karnataka (India)
The purpose of this study was to find out the effect of lead exposure on systolic and diastolic blood pressure, heme biosynthesis related and hematological parameters of automobile workers. For this study 30 automobile workers were selected and compared with 30 age matched healthy control subjects....
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| Veröffentlicht in: | Indian journal of clinical biochemistry 2011-10, Vol.26 (4), p.400-406 |
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| container_title | Indian journal of clinical biochemistry |
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| creator | Dongre, Nilima N. Suryakar, Adinath N. Patil, Arun J. Ambekar, Jeevan G. Rathi, Dileep B. |
| description | The purpose of this study was to find out the effect of lead exposure on systolic and diastolic blood pressure, heme biosynthesis related and hematological parameters of automobile workers. For this study 30 automobile workers were selected and compared with 30 age matched healthy control subjects. Significantly increased blood lead (364%,
P
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| doi_str_mv | 10.1007/s12291-011-0159-6 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3210235</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714406207</galeid><sourcerecordid>A714406207</sourcerecordid><originalsourceid>FETCH-LOGICAL-c603t-d986a7908ee2e8779bb3b17a09b1369a935e5c76e7228543f4e1796cf858afa43</originalsourceid><addsrcrecordid>eNqNktFu0zAUhiMEYmPwANwgCyS0SWTYjhPHN0jdKKyigomBuLSc5KT1ltjFdtD6TjwkzloGRSAhy_KR_Z3_2Md_kjwm-JhgzF96QqkgKSbjzEVa3En2seAsxYzSuzcxTokg-V7ywPtLjDOGGbmf7NEMU8Z4uZ98P9G2XkKva9WhadtCHTyyLZqDatD0emX94ABZgy7WPthO1-g5eq3VNj7prG3QuQM_Yi_QGfSAoqJfm7AErz1Sphl3VeTt4qbIuXKqhwDOI23QZAi2t5XuAH2x7mrcjdXfWxeW6J1yRgV1pdDhzDRaHT1M7rWq8_Boux4kn99MP52epfMPb2enk3laFzgLaSPKQnGBSwAKJeeiqrKKcIVFRbJCKJHlkNe8AE5pmbOsZUC4KOq2zEvVKpYdJK82uquh6qGpwQSnOrlyulduLa3ScvfE6KVc2G8yowTTLI8Ch1sBZ78O4IPsta-h65QBO3hJsMgYKUnO_wMtSckzwUbVp3-gl3aILeq8FJjmJY1khJ5toIXqQGrT2njDetSUE04YwwXFY9Xjv1BxNKMVrIE2_shuwtFOQmQCXIeFGryXs4uPuyzZsLWz3jtobztHsByNKzfGldG4cjSuLGLOk99bfpvx06kRoBvAxyOzAPfr8f9W_QEOIfd2</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>902582818</pqid></control><display><type>article</type><title>Biochemical Effects of Lead Exposure on Systolic & Diastolic Blood Pressure, Heme Biosynthesis and Hematological Parameters in Automobile Workers of North Karnataka (India)</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Dongre, Nilima N. ; Suryakar, Adinath N. ; Patil, Arun J. ; Ambekar, Jeevan G. ; Rathi, Dileep B.</creator><creatorcontrib>Dongre, Nilima N. ; Suryakar, Adinath N. ; Patil, Arun J. ; Ambekar, Jeevan G. ; Rathi, Dileep B.</creatorcontrib><description><![CDATA[The purpose of this study was to find out the effect of lead exposure on systolic and diastolic blood pressure, heme biosynthesis related and hematological parameters of automobile workers. For this study 30 automobile workers were selected and compared with 30 age matched healthy control subjects. Significantly increased blood lead (364%,
P
< 0.001) and urinary lead (176%,
P
< 0.001) levels were observed in automobile workers (study group) as compared to controls. Systolic blood pressure (5.32%,
P
< 0.05) and diastolic blood pressure (5.87%,
P
< 0.05) were significantly increased in the automobile workers as compared to controls. The significantly decreased non-activated erythrocyte δ-aminolevulinic acid dehydratase (δ-ALAD) (−18.51%,
P
< 0.01) and activated δ-ALAD (−13.29%,
P
< 0.05) levels were observed in automobile workers as compared to normal healthy control subjects. But the ratio of activated/non-activated δ-ALAD was significantly increased (43.83%,
P
< 0.001) in automobile workers as compared to controls. Excretions of δ-aminolevulinic acid (83.78%,
P
< 0.001) and porphobilinogen (37%,
P
< 0.001) in urine were significantly increased in the study group as compared to the controls. In automobile workers heamoglobin (−11.51%,
P
< 0.001), hematocrit (−4.06%,
P
< 0.05), mean corpuscle volume (−3.34%,
P
< 0.05), mean corpuscle hemoglobin (−5.66%,
P
< 0.01), mean corpuscle hemoglobin concentration (−7.67%,
P
< 0.001), red blood cell count (−14.6%,
P
< 0.001) were significantly decreased and total white blood cell count (11.44%,
P
< 0.05) increased as compared to the controls. The results of this study clearly indicate that the absorption of lead is more in automobile workers and it affects on blood pressure, heme biosynthesis and hematological parameters observed in this study group.]]></description><identifier>ISSN: 0970-1915</identifier><identifier>EISSN: 0974-0422</identifier><identifier>DOI: 10.1007/s12291-011-0159-6</identifier><identifier>PMID: 23024478</identifier><language>eng</language><publisher>India: Springer-Verlag</publisher><subject>Absorption ; Automobile industry ; Automobiles ; Biochemistry ; Biomedical and Life Sciences ; Biosynthesis ; Blood cell count ; Blood levels ; Blood pressure ; Chemistry/Food Science ; Comparative analysis ; Ethylenediaminetetraacetic acid ; Hematology ; Heme ; Hemoglobin ; Hemoglobin synthesis ; Lead ; Life Sciences ; Microbiology ; Motor vehicles ; Occupational exposure ; Occupational health and safety ; Original ; Original Article ; Pathology ; Physiological aspects ; Urine ; Workers</subject><ispartof>Indian journal of clinical biochemistry, 2011-10, Vol.26 (4), p.400-406</ispartof><rights>Association of Clinical Biochemists of India 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c603t-d986a7908ee2e8779bb3b17a09b1369a935e5c76e7228543f4e1796cf858afa43</citedby><cites>FETCH-LOGICAL-c603t-d986a7908ee2e8779bb3b17a09b1369a935e5c76e7228543f4e1796cf858afa43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210235/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210235/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23024478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dongre, Nilima N.</creatorcontrib><creatorcontrib>Suryakar, Adinath N.</creatorcontrib><creatorcontrib>Patil, Arun J.</creatorcontrib><creatorcontrib>Ambekar, Jeevan G.</creatorcontrib><creatorcontrib>Rathi, Dileep B.</creatorcontrib><title>Biochemical Effects of Lead Exposure on Systolic & Diastolic Blood Pressure, Heme Biosynthesis and Hematological Parameters in Automobile Workers of North Karnataka (India)</title><title>Indian journal of clinical biochemistry</title><addtitle>Ind J Clin Biochem</addtitle><addtitle>Indian J Clin Biochem</addtitle><description><![CDATA[The purpose of this study was to find out the effect of lead exposure on systolic and diastolic blood pressure, heme biosynthesis related and hematological parameters of automobile workers. For this study 30 automobile workers were selected and compared with 30 age matched healthy control subjects. Significantly increased blood lead (364%,
P
< 0.001) and urinary lead (176%,
P
< 0.001) levels were observed in automobile workers (study group) as compared to controls. Systolic blood pressure (5.32%,
P
< 0.05) and diastolic blood pressure (5.87%,
P
< 0.05) were significantly increased in the automobile workers as compared to controls. The significantly decreased non-activated erythrocyte δ-aminolevulinic acid dehydratase (δ-ALAD) (−18.51%,
P
< 0.01) and activated δ-ALAD (−13.29%,
P
< 0.05) levels were observed in automobile workers as compared to normal healthy control subjects. But the ratio of activated/non-activated δ-ALAD was significantly increased (43.83%,
P
< 0.001) in automobile workers as compared to controls. Excretions of δ-aminolevulinic acid (83.78%,
P
< 0.001) and porphobilinogen (37%,
P
< 0.001) in urine were significantly increased in the study group as compared to the controls. In automobile workers heamoglobin (−11.51%,
P
< 0.001), hematocrit (−4.06%,
P
< 0.05), mean corpuscle volume (−3.34%,
P
< 0.05), mean corpuscle hemoglobin (−5.66%,
P
< 0.01), mean corpuscle hemoglobin concentration (−7.67%,
P
< 0.001), red blood cell count (−14.6%,
P
< 0.001) were significantly decreased and total white blood cell count (11.44%,
P
< 0.05) increased as compared to the controls. The results of this study clearly indicate that the absorption of lead is more in automobile workers and it affects on blood pressure, heme biosynthesis and hematological parameters observed in this study group.]]></description><subject>Absorption</subject><subject>Automobile industry</subject><subject>Automobiles</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biosynthesis</subject><subject>Blood cell count</subject><subject>Blood levels</subject><subject>Blood pressure</subject><subject>Chemistry/Food Science</subject><subject>Comparative analysis</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Hematology</subject><subject>Heme</subject><subject>Hemoglobin</subject><subject>Hemoglobin synthesis</subject><subject>Lead</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Motor vehicles</subject><subject>Occupational exposure</subject><subject>Occupational health and safety</subject><subject>Original</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Physiological aspects</subject><subject>Urine</subject><subject>Workers</subject><issn>0970-1915</issn><issn>0974-0422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNktFu0zAUhiMEYmPwANwgCyS0SWTYjhPHN0jdKKyigomBuLSc5KT1ltjFdtD6TjwkzloGRSAhy_KR_Z3_2Md_kjwm-JhgzF96QqkgKSbjzEVa3En2seAsxYzSuzcxTokg-V7ywPtLjDOGGbmf7NEMU8Z4uZ98P9G2XkKva9WhadtCHTyyLZqDatD0emX94ABZgy7WPthO1-g5eq3VNj7prG3QuQM_Yi_QGfSAoqJfm7AErz1Sphl3VeTt4qbIuXKqhwDOI23QZAi2t5XuAH2x7mrcjdXfWxeW6J1yRgV1pdDhzDRaHT1M7rWq8_Boux4kn99MP52epfMPb2enk3laFzgLaSPKQnGBSwAKJeeiqrKKcIVFRbJCKJHlkNe8AE5pmbOsZUC4KOq2zEvVKpYdJK82uquh6qGpwQSnOrlyulduLa3ScvfE6KVc2G8yowTTLI8Ch1sBZ78O4IPsta-h65QBO3hJsMgYKUnO_wMtSckzwUbVp3-gl3aILeq8FJjmJY1khJ5toIXqQGrT2njDetSUE04YwwXFY9Xjv1BxNKMVrIE2_shuwtFOQmQCXIeFGryXs4uPuyzZsLWz3jtobztHsByNKzfGldG4cjSuLGLOk99bfpvx06kRoBvAxyOzAPfr8f9W_QEOIfd2</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Dongre, Nilima N.</creator><creator>Suryakar, Adinath N.</creator><creator>Patil, Arun J.</creator><creator>Ambekar, Jeevan G.</creator><creator>Rathi, Dileep B.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>04Q</scope><scope>04W</scope><scope>3V.</scope><scope>7XB</scope><scope>88A</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20111001</creationdate><title>Biochemical Effects of Lead Exposure on Systolic & Diastolic Blood Pressure, Heme Biosynthesis and Hematological Parameters in Automobile Workers of North Karnataka (India)</title><author>Dongre, Nilima N. ; Suryakar, Adinath N. ; Patil, Arun J. ; Ambekar, Jeevan G. ; Rathi, Dileep B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c603t-d986a7908ee2e8779bb3b17a09b1369a935e5c76e7228543f4e1796cf858afa43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Absorption</topic><topic>Automobile industry</topic><topic>Automobiles</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biosynthesis</topic><topic>Blood cell count</topic><topic>Blood levels</topic><topic>Blood pressure</topic><topic>Chemistry/Food Science</topic><topic>Comparative analysis</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Hematology</topic><topic>Heme</topic><topic>Hemoglobin</topic><topic>Hemoglobin synthesis</topic><topic>Lead</topic><topic>Life Sciences</topic><topic>Microbiology</topic><topic>Motor vehicles</topic><topic>Occupational exposure</topic><topic>Occupational health and safety</topic><topic>Original</topic><topic>Original Article</topic><topic>Pathology</topic><topic>Physiological aspects</topic><topic>Urine</topic><topic>Workers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dongre, Nilima N.</creatorcontrib><creatorcontrib>Suryakar, Adinath N.</creatorcontrib><creatorcontrib>Patil, Arun J.</creatorcontrib><creatorcontrib>Ambekar, Jeevan G.</creatorcontrib><creatorcontrib>Rathi, Dileep B.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>India Database</collection><collection>India Database: Science & Technology</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dongre, Nilima N.</au><au>Suryakar, Adinath N.</au><au>Patil, Arun J.</au><au>Ambekar, Jeevan G.</au><au>Rathi, Dileep B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biochemical Effects of Lead Exposure on Systolic & Diastolic Blood Pressure, Heme Biosynthesis and Hematological Parameters in Automobile Workers of North Karnataka (India)</atitle><jtitle>Indian journal of clinical biochemistry</jtitle><stitle>Ind J Clin Biochem</stitle><addtitle>Indian J Clin Biochem</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>26</volume><issue>4</issue><spage>400</spage><epage>406</epage><pages>400-406</pages><issn>0970-1915</issn><eissn>0974-0422</eissn><abstract><![CDATA[The purpose of this study was to find out the effect of lead exposure on systolic and diastolic blood pressure, heme biosynthesis related and hematological parameters of automobile workers. For this study 30 automobile workers were selected and compared with 30 age matched healthy control subjects. Significantly increased blood lead (364%,
P
< 0.001) and urinary lead (176%,
P
< 0.001) levels were observed in automobile workers (study group) as compared to controls. Systolic blood pressure (5.32%,
P
< 0.05) and diastolic blood pressure (5.87%,
P
< 0.05) were significantly increased in the automobile workers as compared to controls. The significantly decreased non-activated erythrocyte δ-aminolevulinic acid dehydratase (δ-ALAD) (−18.51%,
P
< 0.01) and activated δ-ALAD (−13.29%,
P
< 0.05) levels were observed in automobile workers as compared to normal healthy control subjects. But the ratio of activated/non-activated δ-ALAD was significantly increased (43.83%,
P
< 0.001) in automobile workers as compared to controls. Excretions of δ-aminolevulinic acid (83.78%,
P
< 0.001) and porphobilinogen (37%,
P
< 0.001) in urine were significantly increased in the study group as compared to the controls. In automobile workers heamoglobin (−11.51%,
P
< 0.001), hematocrit (−4.06%,
P
< 0.05), mean corpuscle volume (−3.34%,
P
< 0.05), mean corpuscle hemoglobin (−5.66%,
P
< 0.01), mean corpuscle hemoglobin concentration (−7.67%,
P
< 0.001), red blood cell count (−14.6%,
P
< 0.001) were significantly decreased and total white blood cell count (11.44%,
P
< 0.05) increased as compared to the controls. The results of this study clearly indicate that the absorption of lead is more in automobile workers and it affects on blood pressure, heme biosynthesis and hematological parameters observed in this study group.]]></abstract><cop>India</cop><pub>Springer-Verlag</pub><pmid>23024478</pmid><doi>10.1007/s12291-011-0159-6</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Indian journal of clinical biochemistry, 2011-10, Vol.26 (4), p.400-406 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Absorption Automobile industry Automobiles Biochemistry Biomedical and Life Sciences Biosynthesis Blood cell count Blood levels Blood pressure Chemistry/Food Science Comparative analysis Ethylenediaminetetraacetic acid Hematology Heme Hemoglobin Hemoglobin synthesis Lead Life Sciences Microbiology Motor vehicles Occupational exposure Occupational health and safety Original Original Article Pathology Physiological aspects Urine Workers |
| title | Biochemical Effects of Lead Exposure on Systolic & Diastolic Blood Pressure, Heme Biosynthesis and Hematological Parameters in Automobile Workers of North Karnataka (India) |
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