Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals
Rationale Cue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana use specifically. Objectives The aims of the present study were to evaluate (1) responses to a psychologi...
Gespeichert in:
| Veröffentlicht in: | Psychopharmacology 2011-11, Vol.218 (1), p.49-58 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 58 |
|---|---|
| container_issue | 1 |
| container_start_page | 49 |
| container_title | Psychopharmacology |
| container_volume | 218 |
| creator | McRae-Clark, Aimee L. Carter, Rickey E. Price, Kimber L. Baker, Nathaniel L. Thomas, Suzanne Saladin, Michael E. Giarla, Kathleen Nicholas, Katherine Brady, Kathleen T. |
| description | Rationale
Cue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana use specifically.
Objectives
The aims of the present study were to evaluate (1) responses to a psychological stressor, (2) responses to marijuana-related cues, and (3) if an exposure to a psychological stressor augmented craving subsequently elicited by marijuana-related cue exposure in marijuana-dependent individuals.
Methods
Subjective (craving, stress), neuroendocrine (adrenocorticotropic hormone (ACTH), cortisol), and physiologic responses to the presentation of neutral and marijuana cues were assessed after randomization to a stress (Trier Social Stress Task (TSST)) or non-stress control condition in marijuana-dependent individuals. Outcome measures were assessed at baseline, post-stressor/pre-neutral cue, post-neutral cue, and post-marijuana cue.
Results
Eighty-seven participants completed procedures (stress group,
n
= 45; non-stress group,
n
= 42). The stress group had a significant increase over the non-stress group in stress rating (
p
|
| doi_str_mv | 10.1007/s00213-011-2376-3 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3209966</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A354577961</galeid><sourcerecordid>A354577961</sourcerecordid><originalsourceid>FETCH-LOGICAL-c567t-becf1d8f95b13d696b14ba295dafc0c23422b53cb9d3252862c7b50c5a5c50593</originalsourceid><addsrcrecordid>eNp1UlFvFCEQJo2mvVZ_QF_MRR98oh1gWZaXJk2j1aSJidVnwsLsyWWPvcLuJf33cm5trVF4mDDzfR8z8BFyyuCMAajzDMCZoMAY5ULVVByQBasEpxwUf0EWAEJQwWRzRI5zXkNZVVMdkiPOFAOmYEG-3o4Jc6ZLG_3STUixDy6MWA7J7kJc_SoktG4MuzDeL0NcbmwK68lGSz1uMXqMY0n7UveT7fMr8rIrAV8_xBPy_eOHb1ef6M2X689XlzfUyVqNtEXXMd90WrZM-FrXLatay7X0tnPguKg4b6VwrfaCS97U3KlWgpNWOglSixNyMetup3aD3pU2ku3NNoXS4L0ZbDDPKzH8MKthZwQHreu6CLx_EEjD3YR5NJuQHfa9jThM2WjgohGsgoJ8-xdyPUwplulMo5VolGZ70LsZtLI9mhC7odzq9pLmUshKKqVrVlBn_0CV7XET3BCxCyX_jMBmgktDzgm7xwkZmL0NzGwDU2xg9jYwonDe_Pk0j4zf_14AfAbkUoorTE8D_V_1J5bQvJs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>897387910</pqid></control><display><type>article</type><title>Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>McRae-Clark, Aimee L. ; Carter, Rickey E. ; Price, Kimber L. ; Baker, Nathaniel L. ; Thomas, Suzanne ; Saladin, Michael E. ; Giarla, Kathleen ; Nicholas, Katherine ; Brady, Kathleen T.</creator><creatorcontrib>McRae-Clark, Aimee L. ; Carter, Rickey E. ; Price, Kimber L. ; Baker, Nathaniel L. ; Thomas, Suzanne ; Saladin, Michael E. ; Giarla, Kathleen ; Nicholas, Katherine ; Brady, Kathleen T.</creatorcontrib><description>Rationale
Cue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana use specifically.
Objectives
The aims of the present study were to evaluate (1) responses to a psychological stressor, (2) responses to marijuana-related cues, and (3) if an exposure to a psychological stressor augmented craving subsequently elicited by marijuana-related cue exposure in marijuana-dependent individuals.
Methods
Subjective (craving, stress), neuroendocrine (adrenocorticotropic hormone (ACTH), cortisol), and physiologic responses to the presentation of neutral and marijuana cues were assessed after randomization to a stress (Trier Social Stress Task (TSST)) or non-stress control condition in marijuana-dependent individuals. Outcome measures were assessed at baseline, post-stressor/pre-neutral cue, post-neutral cue, and post-marijuana cue.
Results
Eighty-seven participants completed procedures (stress group,
n
= 45; non-stress group,
n
= 42). The stress group had a significant increase over the non-stress group in stress rating (
p
< 0.001), craving (
p
= 0.028), cortisol (
p
< 0.001), and ACTH (
p
< 0.001) after the completion of the TSST. An increased craving response for all participants was seen following the presentation of the marijuana cues (
p
= 0.005). Following the TSST or non-stress condition, the non-stress group had an increase in craving to marijuana cues as compared to neutral cues (
p
= 0.002); an increase in craving was not observed in the stress group (
p
= 0.404).
Conclusions
Marijuana cue exposure and a social stressor increased craving in marijuana-dependent individuals. Completion of the TSST did not increase craving response to subsequent marijuana cue exposure.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-011-2376-3</identifier><identifier>PMID: 21710170</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>ACTH ; Adolescent ; Adrenocorticotropic hormone ; Adrenocorticotropic Hormone - blood ; Adult ; Biomedical and Life Sciences ; Biomedicine ; Cannabis ; Corticosteroids ; Cues ; Drug dependence ; Female ; Humans ; Hydrocortisone ; Hydrocortisone - blood ; Male ; Marijuana ; Marijuana Abuse - psychology ; Neurosciences ; Original Investigation ; Pharmacology/Toxicology ; Psychiatry ; Psychological Tests ; Psychopharmacology ; Social interactions ; Stress ; Stress, Psychological - psychology ; Young Adult</subject><ispartof>Psychopharmacology, 2011-11, Vol.218 (1), p.49-58</ispartof><rights>Springer-Verlag 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-becf1d8f95b13d696b14ba295dafc0c23422b53cb9d3252862c7b50c5a5c50593</citedby><cites>FETCH-LOGICAL-c567t-becf1d8f95b13d696b14ba295dafc0c23422b53cb9d3252862c7b50c5a5c50593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00213-011-2376-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00213-011-2376-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21710170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McRae-Clark, Aimee L.</creatorcontrib><creatorcontrib>Carter, Rickey E.</creatorcontrib><creatorcontrib>Price, Kimber L.</creatorcontrib><creatorcontrib>Baker, Nathaniel L.</creatorcontrib><creatorcontrib>Thomas, Suzanne</creatorcontrib><creatorcontrib>Saladin, Michael E.</creatorcontrib><creatorcontrib>Giarla, Kathleen</creatorcontrib><creatorcontrib>Nicholas, Katherine</creatorcontrib><creatorcontrib>Brady, Kathleen T.</creatorcontrib><title>Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Rationale
Cue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana use specifically.
Objectives
The aims of the present study were to evaluate (1) responses to a psychological stressor, (2) responses to marijuana-related cues, and (3) if an exposure to a psychological stressor augmented craving subsequently elicited by marijuana-related cue exposure in marijuana-dependent individuals.
Methods
Subjective (craving, stress), neuroendocrine (adrenocorticotropic hormone (ACTH), cortisol), and physiologic responses to the presentation of neutral and marijuana cues were assessed after randomization to a stress (Trier Social Stress Task (TSST)) or non-stress control condition in marijuana-dependent individuals. Outcome measures were assessed at baseline, post-stressor/pre-neutral cue, post-neutral cue, and post-marijuana cue.
Results
Eighty-seven participants completed procedures (stress group,
n
= 45; non-stress group,
n
= 42). The stress group had a significant increase over the non-stress group in stress rating (
p
< 0.001), craving (
p
= 0.028), cortisol (
p
< 0.001), and ACTH (
p
< 0.001) after the completion of the TSST. An increased craving response for all participants was seen following the presentation of the marijuana cues (
p
= 0.005). Following the TSST or non-stress condition, the non-stress group had an increase in craving to marijuana cues as compared to neutral cues (
p
= 0.002); an increase in craving was not observed in the stress group (
p
= 0.404).
Conclusions
Marijuana cue exposure and a social stressor increased craving in marijuana-dependent individuals. Completion of the TSST did not increase craving response to subsequent marijuana cue exposure.</description><subject>ACTH</subject><subject>Adolescent</subject><subject>Adrenocorticotropic hormone</subject><subject>Adrenocorticotropic Hormone - blood</subject><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cannabis</subject><subject>Corticosteroids</subject><subject>Cues</subject><subject>Drug dependence</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone</subject><subject>Hydrocortisone - blood</subject><subject>Male</subject><subject>Marijuana</subject><subject>Marijuana Abuse - psychology</subject><subject>Neurosciences</subject><subject>Original Investigation</subject><subject>Pharmacology/Toxicology</subject><subject>Psychiatry</subject><subject>Psychological Tests</subject><subject>Psychopharmacology</subject><subject>Social interactions</subject><subject>Stress</subject><subject>Stress, Psychological - psychology</subject><subject>Young Adult</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1UlFvFCEQJo2mvVZ_QF_MRR98oh1gWZaXJk2j1aSJidVnwsLsyWWPvcLuJf33cm5trVF4mDDzfR8z8BFyyuCMAajzDMCZoMAY5ULVVByQBasEpxwUf0EWAEJQwWRzRI5zXkNZVVMdkiPOFAOmYEG-3o4Jc6ZLG_3STUixDy6MWA7J7kJc_SoktG4MuzDeL0NcbmwK68lGSz1uMXqMY0n7UveT7fMr8rIrAV8_xBPy_eOHb1ef6M2X689XlzfUyVqNtEXXMd90WrZM-FrXLatay7X0tnPguKg4b6VwrfaCS97U3KlWgpNWOglSixNyMetup3aD3pU2ku3NNoXS4L0ZbDDPKzH8MKthZwQHreu6CLx_EEjD3YR5NJuQHfa9jThM2WjgohGsgoJ8-xdyPUwplulMo5VolGZ70LsZtLI9mhC7odzq9pLmUshKKqVrVlBn_0CV7XET3BCxCyX_jMBmgktDzgm7xwkZmL0NzGwDU2xg9jYwonDe_Pk0j4zf_14AfAbkUoorTE8D_V_1J5bQvJs</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>McRae-Clark, Aimee L.</creator><creator>Carter, Rickey E.</creator><creator>Price, Kimber L.</creator><creator>Baker, Nathaniel L.</creator><creator>Thomas, Suzanne</creator><creator>Saladin, Michael E.</creator><creator>Giarla, Kathleen</creator><creator>Nicholas, Katherine</creator><creator>Brady, Kathleen T.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20111101</creationdate><title>Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals</title><author>McRae-Clark, Aimee L. ; Carter, Rickey E. ; Price, Kimber L. ; Baker, Nathaniel L. ; Thomas, Suzanne ; Saladin, Michael E. ; Giarla, Kathleen ; Nicholas, Katherine ; Brady, Kathleen T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-becf1d8f95b13d696b14ba295dafc0c23422b53cb9d3252862c7b50c5a5c50593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>ACTH</topic><topic>Adolescent</topic><topic>Adrenocorticotropic hormone</topic><topic>Adrenocorticotropic Hormone - blood</topic><topic>Adult</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cannabis</topic><topic>Corticosteroids</topic><topic>Cues</topic><topic>Drug dependence</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone</topic><topic>Hydrocortisone - blood</topic><topic>Male</topic><topic>Marijuana</topic><topic>Marijuana Abuse - psychology</topic><topic>Neurosciences</topic><topic>Original Investigation</topic><topic>Pharmacology/Toxicology</topic><topic>Psychiatry</topic><topic>Psychological Tests</topic><topic>Psychopharmacology</topic><topic>Social interactions</topic><topic>Stress</topic><topic>Stress, Psychological - psychology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McRae-Clark, Aimee L.</creatorcontrib><creatorcontrib>Carter, Rickey E.</creatorcontrib><creatorcontrib>Price, Kimber L.</creatorcontrib><creatorcontrib>Baker, Nathaniel L.</creatorcontrib><creatorcontrib>Thomas, Suzanne</creatorcontrib><creatorcontrib>Saladin, Michael E.</creatorcontrib><creatorcontrib>Giarla, Kathleen</creatorcontrib><creatorcontrib>Nicholas, Katherine</creatorcontrib><creatorcontrib>Brady, Kathleen T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McRae-Clark, Aimee L.</au><au>Carter, Rickey E.</au><au>Price, Kimber L.</au><au>Baker, Nathaniel L.</au><au>Thomas, Suzanne</au><au>Saladin, Michael E.</au><au>Giarla, Kathleen</au><au>Nicholas, Katherine</au><au>Brady, Kathleen T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>218</volume><issue>1</issue><spage>49</spage><epage>58</epage><pages>49-58</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Rationale
Cue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana use specifically.
Objectives
The aims of the present study were to evaluate (1) responses to a psychological stressor, (2) responses to marijuana-related cues, and (3) if an exposure to a psychological stressor augmented craving subsequently elicited by marijuana-related cue exposure in marijuana-dependent individuals.
Methods
Subjective (craving, stress), neuroendocrine (adrenocorticotropic hormone (ACTH), cortisol), and physiologic responses to the presentation of neutral and marijuana cues were assessed after randomization to a stress (Trier Social Stress Task (TSST)) or non-stress control condition in marijuana-dependent individuals. Outcome measures were assessed at baseline, post-stressor/pre-neutral cue, post-neutral cue, and post-marijuana cue.
Results
Eighty-seven participants completed procedures (stress group,
n
= 45; non-stress group,
n
= 42). The stress group had a significant increase over the non-stress group in stress rating (
p
< 0.001), craving (
p
= 0.028), cortisol (
p
< 0.001), and ACTH (
p
< 0.001) after the completion of the TSST. An increased craving response for all participants was seen following the presentation of the marijuana cues (
p
= 0.005). Following the TSST or non-stress condition, the non-stress group had an increase in craving to marijuana cues as compared to neutral cues (
p
= 0.002); an increase in craving was not observed in the stress group (
p
= 0.404).
Conclusions
Marijuana cue exposure and a social stressor increased craving in marijuana-dependent individuals. Completion of the TSST did not increase craving response to subsequent marijuana cue exposure.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21710170</pmid><doi>10.1007/s00213-011-2376-3</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacology, 2011-11, Vol.218 (1), p.49-58 |
| issn | 0033-3158 1432-2072 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3209966 |
| source | MEDLINE; SpringerLink Journals |
| subjects | ACTH Adolescent Adrenocorticotropic hormone Adrenocorticotropic Hormone - blood Adult Biomedical and Life Sciences Biomedicine Cannabis Corticosteroids Cues Drug dependence Female Humans Hydrocortisone Hydrocortisone - blood Male Marijuana Marijuana Abuse - psychology Neurosciences Original Investigation Pharmacology/Toxicology Psychiatry Psychological Tests Psychopharmacology Social interactions Stress Stress, Psychological - psychology Young Adult |
| title | Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T08%3A41%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stress-%20and%20cue-elicited%20craving%20and%20reactivity%20in%20marijuana-dependent%20individuals&rft.jtitle=Psychopharmacology&rft.au=McRae-Clark,%20Aimee%20L.&rft.date=2011-11-01&rft.volume=218&rft.issue=1&rft.spage=49&rft.epage=58&rft.pages=49-58&rft.issn=0033-3158&rft.eissn=1432-2072&rft_id=info:doi/10.1007/s00213-011-2376-3&rft_dat=%3Cgale_pubme%3EA354577961%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=897387910&rft_id=info:pmid/21710170&rft_galeid=A354577961&rfr_iscdi=true |