Epigenetic Regulation of Polymerase II Transcription Initiation in Trypanosoma cruzi: Modulation of Nucleosome Abundance, Histone Modification, and Polymerase Occupancy by O-Linked Thymine DNA Glucosylation

Very little is understood regarding how transcription is initiated/regulated in the early-diverging eukaryote Trypanosoma cruzi. Unusually for a eukaryote, genes transcribed by RNA polymerase (Pol) II in T. cruzi are arranged in polycistronic transcription units (PTUs). On the basis of this gene org...

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Veröffentlicht in:	Eukaryotic Cell 2011-11, Vol.10 (11), p.1465-1472
Hauptverfasser:	Ekanayake, Dilrukshi, Sabatini, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Chromatin - ultrastructure DNA DNA, Protozoan - metabolism DNA-directed RNA polymerase Epigenesis, Genetic epigenetics eukaryotic cells gene expression Gene Expression Regulation genes Glucosides - chemistry Glucosides - genetics Glucosides - metabolism Glycosylation histones Histones - metabolism Nucleosomes promoter regions Promoter Regions, Genetic Protozoan Proteins - genetics Protozoan Proteins - metabolism recruitment RNA RNA Polymerase II - metabolism thymidine thymine Thymine DNA Glycosylase Transcription, Genetic Trypanosoma cruzi Trypanosoma cruzi - genetics Trypanosoma cruzi - metabolism Uracil - analogs & derivatives Uracil - chemistry Uracil - metabolism
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