In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins

Abstract The gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), replicates to high titers in some human cell lines and is able to infect non-human primates. To determine whether APOBEC3 (A3) proteins restrict XMRV infections in a non-human primate model, we sequenced proviral DN...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2011-12, Vol.421 (1), p.28-33
Hauptverfasser:	Zhang, Ao, Bogerd, Hal, Villinger, Francois, Gupta, Jaydip Das, Dong, Beihua, Klein, Eric A, Hackett, John, Schochetman, Gerald, Cullen, Bryan R, Silverman, Robert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals APOBEC3 Base Sequence Cell Line Cytosine Deaminase - genetics Cytosine Deaminase - metabolism Disease Models, Animal DNA, Viral - genetics DNA, Viral - metabolism Female Host restriction Humans Hypermutation Infectious Disease Innate immunity Leukocytes, Mononuclear - enzymology Leukocytes, Mononuclear - virology Macaca mulatta Male Molecular Sequence Data Mutation Primates Retroviridae Infections - enzymology Retroviridae Infections - virology Retrovirus Virus Replication Xenotropic murine leukemia virus-related virus - genetics Xenotropic murine leukemia virus-related virus - physiology XMRV
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