Telomere Length Is a Determinant of Emphysema Susceptibility

Germline mutations in the enzyme telomerase cause telomere shortening, and have their most common clinical manifestation in age-related lung disease that manifests as idiopathic pulmonary fibrosis. Short telomeres are also a unique heritable trait that is acquired with age. We sought to understand t...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2011-10, Vol.184 (8), p.904-912
Hauptverfasser:	ALDER, Jonathan K, GUO, Nini, TUDER, Rubin M, ARMANIOS, Mary, KEMBOU, Frant, PARRY, Erin M, ANDERSON, Collin J, GORGY, Amany I, WALSH, Michael F, SUSSAN, Thomas, BISWAL, Shyam, MITZNER, Wayne
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bone marrow Bone Marrow Transplantation Cell cycle Cell division Cigarettes Cyclin-dependent kinases Defects DNA Damage Emphysema Female Fluorescent Antibody Technique Genetic Predisposition to Disease Idiopathic Pulmonary Fibrosis - enzymology Idiopathic Pulmonary Fibrosis - genetics Intensive care medicine Kinases Lung diseases Lungs Male Medical sciences Mice Mice, Inbred C57BL Miscellaneous Mutation Nicotiana - adverse effects Pulmonary Emphysema - chemically induced Pulmonary Emphysema - enzymology Pulmonary Emphysema - genetics Pulmonary Emphysema - surgery Pulmonary fibrosis Real-Time Polymerase Chain Reaction Respiratory Function Tests Reverse Transcriptase Polymerase Chain Reaction Senescence Smoke - adverse effects Telomerase Telomerase - deficiency Telomerase - genetics Telomere - chemistry Yeast
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