Cilostazol minimizes venous ischemic injury in diabetic and normal rats

We evaluated the effects of cilostazol on venous infarction produced by a photothrombotic two-vein occlusion (2VO) model in diabetic and control rats. The cerebral blood flow (CBF) between the occluded veins was measured by laser Doppler flowmetry for 4 hours after 2VO. Infarct size and immunohistoc...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2011-10, Vol.31 (10), p.2030-2040
Hauptverfasser:	Wajima, Daisuke, Nakamura, Mitsutoshi, Horiuchi, Kaoru, Takeshima, Yasuhiro, Nishimura, Fumihiko, Nakase, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Biological and medical sciences Brain Infarction - drug therapy Brain Infarction - metabolism Brain Infarction - pathology Brain Infarction - physiopathology Cerebrovascular Circulation - drug effects Diabetes Mellitus - drug therapy Diabetes Mellitus - metabolism Diabetes Mellitus - pathology Diabetes Mellitus - physiopathology Fibrinolytic Agents - pharmacology Immunohistochemistry Male Medical sciences Neurology Neuropharmacology Neuroprotective agent Original Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Species Specificity Tetrazoles - pharmacology Time Factors Vascular diseases and vascular malformations of the nervous system
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