MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: A Children's Oncology Group (COG) study
Background Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements. Procedure Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age. R...
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| Veröffentlicht in: | Pediatric blood & cancer 2012-06, Vol.58 (6), p.836-839 |
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| container_title | Pediatric blood & cancer |
| container_volume | 58 |
| creator | Sam, Thien N. Kersey, John H. Linabery, Amy M. Johnson, Kimberly J. Heerema, Nyla A. Hilden, Joanne M. Davies, Stella M. Reaman, Gregory H. Ross, Julie A. |
| description | Background
Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements.
Procedure
Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age.
Results
Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases.
Conclusion
These patterns may provide important etiological insight into the biology of infant leukemia. Pediatr Blood Cancer 2012; 58: 836–839. © 2011 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/pbc.23274 |
| format | Article |
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Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements.
Procedure
Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age.
Results
Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases.
Conclusion
These patterns may provide important etiological insight into the biology of infant leukemia. Pediatr Blood Cancer 2012; 58: 836–839. © 2011 Wiley Periodicals, Inc.</description><identifier>ISSN: 1545-5009</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.23274</identifier><identifier>PMID: 21800415</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Age Distribution ; Age of Onset ; epidemiology ; Female ; Gene Rearrangement ; Histone-Lysine N-Methyltransferase ; Humans ; Infant ; Infant, Newborn ; infants ; Kaplan-Meier Estimate ; leukemia ; Leukemia - epidemiology ; Leukemia - genetics ; Male ; MLL ; Myeloid-Lymphoid Leukemia Protein - genetics ; Sex Distribution</subject><ispartof>Pediatric blood & cancer, 2012-06, Vol.58 (6), p.836-839</ispartof><rights>Copyright © 2011 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4524-dfbc0cea5dd79a8a06bb1be807fbfe431857274b122a622a2e018d7cadbdedd93</citedby><cites>FETCH-LOGICAL-c4524-dfbc0cea5dd79a8a06bb1be807fbfe431857274b122a622a2e018d7cadbdedd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpbc.23274$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpbc.23274$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21800415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sam, Thien N.</creatorcontrib><creatorcontrib>Kersey, John H.</creatorcontrib><creatorcontrib>Linabery, Amy M.</creatorcontrib><creatorcontrib>Johnson, Kimberly J.</creatorcontrib><creatorcontrib>Heerema, Nyla A.</creatorcontrib><creatorcontrib>Hilden, Joanne M.</creatorcontrib><creatorcontrib>Davies, Stella M.</creatorcontrib><creatorcontrib>Reaman, Gregory H.</creatorcontrib><creatorcontrib>Ross, Julie A.</creatorcontrib><title>MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: A Children's Oncology Group (COG) study</title><title>Pediatric blood & cancer</title><addtitle>Pediatr. Blood Cancer</addtitle><description>Background
Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements.
Procedure
Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age.
Results
Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases.
Conclusion
These patterns may provide important etiological insight into the biology of infant leukemia. Pediatr Blood Cancer 2012; 58: 836–839. © 2011 Wiley Periodicals, Inc.</description><subject>Age Distribution</subject><subject>Age of Onset</subject><subject>epidemiology</subject><subject>Female</subject><subject>Gene Rearrangement</subject><subject>Histone-Lysine N-Methyltransferase</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>infants</subject><subject>Kaplan-Meier Estimate</subject><subject>leukemia</subject><subject>Leukemia - epidemiology</subject><subject>Leukemia - genetics</subject><subject>Male</subject><subject>MLL</subject><subject>Myeloid-Lymphoid Leukemia Protein - genetics</subject><subject>Sex Distribution</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAURiMEoqWw4AWQd6WLtLbzzwKpjdoBKTBdgFhaN_ZNxjSxg520nafglTFMO4IFki1b8rnHvv6i6DWjp4xSfja18pQnvEifRIcsS7M4o6x4ut_T6iB64f33gOY0K59HB5yVlKYsO4x-fmoa0qNB4hCcA9PjiGb2RJswOjAzGXC5wVEDuQW3JXd63hDokcBMlIbeWK89AaOIxwHljIooHG3vYNpoSTqQs3X-HTkn9UYPyqE59mRtpB1svyUrZ5eJvK3XqxPi50VtX0bPOhg8vnpYj6KvV5df6g9xs159rM-bWKYZT2PVtZJKhEypooISaN62rMWSFl3bYZqwMivCf7SMc8jD5EhZqQoJqlWoVJUcRe933mlpR1Qy9OxgEJPTY-hSWNDi3xOjN6K3tyLhtAzWIDh-EDj7Y0E_i1F7icMABu3iRcWrjOYVKwN5siOls9477Pa3MCp-5ydCfuJPfoF98_ez9uRjYAE42wF3esDt_03i-qJ-VMa7Cu1nvN9XgLsReZEUmfj2eSWalFXl1fWFaJJfc8228A</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Sam, Thien N.</creator><creator>Kersey, John H.</creator><creator>Linabery, Amy M.</creator><creator>Johnson, Kimberly J.</creator><creator>Heerema, Nyla A.</creator><creator>Hilden, Joanne M.</creator><creator>Davies, Stella M.</creator><creator>Reaman, Gregory H.</creator><creator>Ross, Julie A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201206</creationdate><title>MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: A Children's Oncology Group (COG) study</title><author>Sam, Thien N. ; Kersey, John H. ; Linabery, Amy M. ; Johnson, Kimberly J. ; Heerema, Nyla A. ; Hilden, Joanne M. ; Davies, Stella M. ; Reaman, Gregory H. ; Ross, Julie A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4524-dfbc0cea5dd79a8a06bb1be807fbfe431857274b122a622a2e018d7cadbdedd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age Distribution</topic><topic>Age of Onset</topic><topic>epidemiology</topic><topic>Female</topic><topic>Gene Rearrangement</topic><topic>Histone-Lysine N-Methyltransferase</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>infants</topic><topic>Kaplan-Meier Estimate</topic><topic>leukemia</topic><topic>Leukemia - epidemiology</topic><topic>Leukemia - genetics</topic><topic>Male</topic><topic>MLL</topic><topic>Myeloid-Lymphoid Leukemia Protein - genetics</topic><topic>Sex Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sam, Thien N.</creatorcontrib><creatorcontrib>Kersey, John H.</creatorcontrib><creatorcontrib>Linabery, Amy M.</creatorcontrib><creatorcontrib>Johnson, Kimberly J.</creatorcontrib><creatorcontrib>Heerema, Nyla A.</creatorcontrib><creatorcontrib>Hilden, Joanne M.</creatorcontrib><creatorcontrib>Davies, Stella M.</creatorcontrib><creatorcontrib>Reaman, Gregory H.</creatorcontrib><creatorcontrib>Ross, Julie A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric blood & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sam, Thien N.</au><au>Kersey, John H.</au><au>Linabery, Amy M.</au><au>Johnson, Kimberly J.</au><au>Heerema, Nyla A.</au><au>Hilden, Joanne M.</au><au>Davies, Stella M.</au><au>Reaman, Gregory H.</au><au>Ross, Julie A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: A Children's Oncology Group (COG) study</atitle><jtitle>Pediatric blood & cancer</jtitle><addtitle>Pediatr. Blood Cancer</addtitle><date>2012-06</date><risdate>2012</risdate><volume>58</volume><issue>6</issue><spage>836</spage><epage>839</epage><pages>836-839</pages><issn>1545-5009</issn><eissn>1545-5017</eissn><abstract>Background
Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements.
Procedure
Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age.
Results
Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases.
Conclusion
These patterns may provide important etiological insight into the biology of infant leukemia. Pediatr Blood Cancer 2012; 58: 836–839. © 2011 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21800415</pmid><doi>10.1002/pbc.23274</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Age Distribution Age of Onset epidemiology Female Gene Rearrangement Histone-Lysine N-Methyltransferase Humans Infant Infant, Newborn infants Kaplan-Meier Estimate leukemia Leukemia - epidemiology Leukemia - genetics Male MLL Myeloid-Lymphoid Leukemia Protein - genetics Sex Distribution |
| title | MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: A Children's Oncology Group (COG) study |
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