Characterization of Mg2+ Inhibition of Mitochondrial Ca2+ Uptake by a Mechanistic Model of Mitochondrial Ca2+ Uniporter

Ca2+ is an important regulatory ion and alteration of mitochondrial Ca2+ homeostasis can lead to cellular dysfunction and apoptosis. Ca2+ is transported into respiring mitochondria via the Ca2+ uniporter, which is known to be inhibited by Mg2+. This uniporter-mediated mitochondrial Ca2+ transport is...

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Veröffentlicht in:	Biophysical journal 2011-11, Vol.101 (9), p.2071-2081
Hauptverfasser:	Pradhan, Ranjan K., Qi, Feng, Beard, Daniel A., Dash, Ranjan K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Biological Systems and Multicellular Dynamics Biological Transport - drug effects calcium Calcium - metabolism Calcium Channels - metabolism data collection energy energy metabolism homeostasis Kinetics magnesium Magnesium - pharmacology mechanistic models mitochondria Mitochondria - drug effects Mitochondria - metabolism Models, Biological phosphates Rats signal transduction
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