A Phase I Trial of Liposomal Doxorubicin, Bevacizumab, and Temsirolimus in Patients with Advanced Gynecologic and Breast Malignancies

Liposomal doxorubicin (D) and bevacizumab (A) are active single agents in gynecologic and breast malignancies which share a resistance mechanism: upregulation of hypoxia inducible factor (HIF-1α). We, therefore, added temsirolimus (T), which inhibits HIF-1α, to D and A (DAT). Trial objectives were a...

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Veröffentlicht in:	Clinical cancer research 2011-11, Vol.17 (21), p.6840-6846
Hauptverfasser:	MORONEY, John W, SCHLUMBRECHT, Matthew P, HELGASON, Thorunn, COLEMAN, Robert L, MOULDER, Stacy, NAING, Aung, BODURKA, Diane C, JANKU, Filip, HONG, David S, KURZROCK, Razelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Bevacizumab Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - genetics Class I Phosphatidylinositol 3-Kinases Dose-Response Relationship, Drug Doxorubicin - administration & dosage Doxorubicin - adverse effects Drug Administration Schedule Female Genital Neoplasms, Female - drug therapy Genital Neoplasms, Female - genetics Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Middle Aged Mutation Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) PTEN Phosphohydrolase - genetics ras Proteins - genetics Sirolimus - administration & dosage Sirolimus - adverse effects Sirolimus - analogs & derivatives Survival Rate Tumors
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