A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

The canonical role of messenger RNA (mRNA) is to deliver protein-coding information to sites of protein synthesis. However, given that microRNAs bind to RNAs, we hypothesized that RNAs could possess a regulatory role that relies on their ability to compete for microRNA binding, independently of thei...

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Veröffentlicht in:	Nature (London) 2010-06, Vol.465 (7301), p.1033-1038
Hauptverfasser:	Poliseno, Laura, Salmena, Leonardo, Zhang, Jiangwen, Carver, Brett, Haveman, William J., Pandolfi, Pier Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics 631/208/68 631/337 631/67 Binding sites Binding, Competitive Biological and medical sciences Biology Cancer Cell Line Gene expression Gene Expression Regulation, Neoplastic - genetics Genes, Tumor Suppressor Humanities and Social Sciences Humans Medical sciences MicroRNAs - genetics Models, Genetic multidisciplinary Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Mutation Neoplasms - genetics Protein synthesis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) Pseudogenes - genetics PTEN Phosphohydrolase - genetics ras Proteins - genetics RNA, Messenger - genetics Rodents Science Science (multidisciplinary) Tumors
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