Prediagnostic Plasma IgE Levels and Risk of Adult Glioma in Four Prospective Cohort Studies
Background Increased levels of serum immunoglobulin E (IgE) because of allergies have been inversely associated with risk of glioma in observational studies. Despite consistency across studies examining history of allergies and glioma, questions remain as to whether those are causal associations. An...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 2011-11, Vol.103 (21), p.1588-1595 |
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| creator | Calboli, Federico C. F. Cox, David G. Buring, Julie E. Gaziano, J. Michael Ma, Jing Stampfer, Meir Willett, Walter C. Tworoger, Shelley S. Hunter, David J. Camargo, Carlos A. Michaud, Dominique S. |
| description | Background
Increased levels of serum immunoglobulin E (IgE) because of allergies have been inversely associated with risk of glioma in observational studies. Despite consistency across studies examining history of allergies and glioma, questions remain as to whether those are causal associations. An inverse association between serum IgE and risk of glioma was reported in a large case-control study, but reverse causality and treatment effects remain potential explanations for those findings.
Methods
We combined data from four prospective cohort studies and used a nested case-control design to examine the association between allergy and glioma. We included glioma case subjects who were confirmed from medical or pathology records or from death certificates, and with prediagnostic blood available. We matched three control subjects per case subject, and the final numbers for analyses were 169 case subjects and 520 control subjects. Total IgE, food allergen-specific IgE, and respiratory allergen-specific IgE levels were measured using a highly sensitive fluorescent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression analysis. Stratified analyses were conducted by age and birth cohorts.
Results
Borderline elevated total IgE levels (25-100 kU/L) showed a statistically significant inverse association with glioma (OR = 0.63, 95% CI = 0.42 to 0.93), but no association was noted between elevated IgE (>100 kU/L) and glioma (OR = 0.98, 95% CI = 0.61 to 1.56) compared with clinically normal IgE levels ( |
| doi_str_mv | 10.1093/jnci/djr361 |
| format | Article |
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Increased levels of serum immunoglobulin E (IgE) because of allergies have been inversely associated with risk of glioma in observational studies. Despite consistency across studies examining history of allergies and glioma, questions remain as to whether those are causal associations. An inverse association between serum IgE and risk of glioma was reported in a large case-control study, but reverse causality and treatment effects remain potential explanations for those findings.
Methods
We combined data from four prospective cohort studies and used a nested case-control design to examine the association between allergy and glioma. We included glioma case subjects who were confirmed from medical or pathology records or from death certificates, and with prediagnostic blood available. We matched three control subjects per case subject, and the final numbers for analyses were 169 case subjects and 520 control subjects. Total IgE, food allergen-specific IgE, and respiratory allergen-specific IgE levels were measured using a highly sensitive fluorescent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression analysis. Stratified analyses were conducted by age and birth cohorts.
Results
Borderline elevated total IgE levels (25-100 kU/L) showed a statistically significant inverse association with glioma (OR = 0.63, 95% CI = 0.42 to 0.93), but no association was noted between elevated IgE (>100 kU/L) and glioma (OR = 0.98, 95% CI = 0.61 to 1.56) compared with clinically normal IgE levels (<25 kU/L). The association between glioma and total IgE was consistent for both men and women. Non-statistically significant inverse associations were noted for elevated IgE levels among individuals born before year 1930 (OR = 0.67, 95% CI = 0.34 to 1.34) and when restricting analyses to highly fatal (deceased within 2 years of diagnosis) glioma case subjects (OR = 0.64, 95% CI = 0.34 to 1.19) compared with individuals with clinically normal IgE levels. No associations were observed for either food allergen-specific or respiratory allergen-specific IgE levels.
Conclusions
Overall, our prospective findings are consistent with recent retrospective studies and support an association between total IgE levels and glioma. However, this association requires further elucidation.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/djr361</identifier><identifier>PMID: 22010181</identifier><identifier>CODEN: JNCIEQ</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Aged ; Allergens ; Allergens - immunology ; Allergies ; Asthma ; Asthma - complications ; Biological and medical sciences ; Brain Neoplasms ; Brain Neoplasms - diagnosis ; Brain Neoplasms - immunology ; Cancer ; Case-Control Studies ; Cohort Studies ; Female ; Glioma ; Glioma - diagnosis ; Glioma - immunology ; Humans ; Hypersensitivity ; Hypersensitivity - complications ; Hypersensitivity - immunology ; Immunoglobulin E ; Immunoglobulin E - blood ; Life Sciences ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Neurology ; Odds Ratio ; Prospective Studies ; Research Design ; Risk Assessment ; Risk Factors ; Studies ; Time Factors ; Tumors ; Tumors of the nervous system. Phacomatoses</subject><ispartof>JNCI : Journal of the National Cancer Institute, 2011-11, Vol.103 (21), p.1588-1595</ispartof><rights>The Author 2011. Published by Oxford University Press. 2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Nov 2, 2011</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-1c768f5ec20dcd752754b413dd11d7dff9cb322db54b21edebe0db353a7254fa3</citedby><cites>FETCH-LOGICAL-c534t-1c768f5ec20dcd752754b413dd11d7dff9cb322db54b21edebe0db353a7254fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24758744$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22010181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00787041$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Calboli, Federico C. F.</creatorcontrib><creatorcontrib>Cox, David G.</creatorcontrib><creatorcontrib>Buring, Julie E.</creatorcontrib><creatorcontrib>Gaziano, J. Michael</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Stampfer, Meir</creatorcontrib><creatorcontrib>Willett, Walter C.</creatorcontrib><creatorcontrib>Tworoger, Shelley S.</creatorcontrib><creatorcontrib>Hunter, David J.</creatorcontrib><creatorcontrib>Camargo, Carlos A.</creatorcontrib><creatorcontrib>Michaud, Dominique S.</creatorcontrib><title>Prediagnostic Plasma IgE Levels and Risk of Adult Glioma in Four Prospective Cohort Studies</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>J Natl Cancer Inst</addtitle><description>Background
Increased levels of serum immunoglobulin E (IgE) because of allergies have been inversely associated with risk of glioma in observational studies. Despite consistency across studies examining history of allergies and glioma, questions remain as to whether those are causal associations. An inverse association between serum IgE and risk of glioma was reported in a large case-control study, but reverse causality and treatment effects remain potential explanations for those findings.
Methods
We combined data from four prospective cohort studies and used a nested case-control design to examine the association between allergy and glioma. We included glioma case subjects who were confirmed from medical or pathology records or from death certificates, and with prediagnostic blood available. We matched three control subjects per case subject, and the final numbers for analyses were 169 case subjects and 520 control subjects. Total IgE, food allergen-specific IgE, and respiratory allergen-specific IgE levels were measured using a highly sensitive fluorescent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression analysis. Stratified analyses were conducted by age and birth cohorts.
Results
Borderline elevated total IgE levels (25-100 kU/L) showed a statistically significant inverse association with glioma (OR = 0.63, 95% CI = 0.42 to 0.93), but no association was noted between elevated IgE (>100 kU/L) and glioma (OR = 0.98, 95% CI = 0.61 to 1.56) compared with clinically normal IgE levels (<25 kU/L). The association between glioma and total IgE was consistent for both men and women. Non-statistically significant inverse associations were noted for elevated IgE levels among individuals born before year 1930 (OR = 0.67, 95% CI = 0.34 to 1.34) and when restricting analyses to highly fatal (deceased within 2 years of diagnosis) glioma case subjects (OR = 0.64, 95% CI = 0.34 to 1.19) compared with individuals with clinically normal IgE levels. No associations were observed for either food allergen-specific or respiratory allergen-specific IgE levels.
Conclusions
Overall, our prospective findings are consistent with recent retrospective studies and support an association between total IgE levels and glioma. However, this association requires further elucidation.</description><subject>Adult</subject><subject>Aged</subject><subject>Allergens</subject><subject>Allergens - immunology</subject><subject>Allergies</subject><subject>Asthma</subject><subject>Asthma - complications</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - immunology</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Glioma</subject><subject>Glioma - diagnosis</subject><subject>Glioma - immunology</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Hypersensitivity - complications</subject><subject>Hypersensitivity - immunology</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>Life Sciences</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Prospective Studies</subject><subject>Research Design</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Time Factors</subject><subject>Tumors</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0s2LEzEUAPAgilt3PXmXIKiIjPvyMZOZi1DKfkFhy6onDyGTZNrU6aSbzBT2v9-Uqavuwc0lkPzee-HlIfSGwBcCFTtdd9qdmnVgBXmGJoQXkFEC-XM0AaAiK0vBj9CrGNeQVkX5S3REKRAgJZmgn4tgjVPLzsfeabxoVdwofLU8w3O7s23EqjP4xsVf2Dd4aoa2xxet88m4Dp_7IeBF8HFrde92Fs_8yocef-sH42w8QS8a1Ub7-rAfox_nZ99nl9n8-uJqNp1nOme8z4gWRdnkVlMw2oicipzXnDBjCDHCNE2la0apqdMxJdbY2oKpWc6UoDlvFDtGX8e826HeWKNt1wfVym1wGxXupFdO_nvTuZVc-p1kFApgZUrwaUywehR2OZ3L_RmAKAVwsiPJfjwUC_52sLGXGxe1bVvVWT9EWZESCl4R8bQECqUQApJ890iuU2e71LOECiKqirKEPo9Ip4bHYJuHlxKQ-0GQ-0GQ4yAk_fbvnjzY3z-fwPsDUFGrtgkqRcc_jos8DQ5P7sPo_LD9b8V761TI_A</recordid><startdate>20111102</startdate><enddate>20111102</enddate><creator>Calboli, Federico C. F.</creator><creator>Cox, David G.</creator><creator>Buring, Julie E.</creator><creator>Gaziano, J. Michael</creator><creator>Ma, Jing</creator><creator>Stampfer, Meir</creator><creator>Willett, Walter C.</creator><creator>Tworoger, Shelley S.</creator><creator>Hunter, David J.</creator><creator>Camargo, Carlos A.</creator><creator>Michaud, Dominique S.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><general>Oxford University Press (OUP)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>1XC</scope><scope>5PM</scope></search><sort><creationdate>20111102</creationdate><title>Prediagnostic Plasma IgE Levels and Risk of Adult Glioma in Four Prospective Cohort Studies</title><author>Calboli, Federico C. F. ; Cox, David G. ; Buring, Julie E. ; Gaziano, J. Michael ; Ma, Jing ; Stampfer, Meir ; Willett, Walter C. ; Tworoger, Shelley S. ; Hunter, David J. ; Camargo, Carlos A. ; Michaud, Dominique S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-1c768f5ec20dcd752754b413dd11d7dff9cb322db54b21edebe0db353a7254fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allergens</topic><topic>Allergens - immunology</topic><topic>Allergies</topic><topic>Asthma</topic><topic>Asthma - complications</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - immunology</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Glioma</topic><topic>Glioma - diagnosis</topic><topic>Glioma - immunology</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Hypersensitivity - complications</topic><topic>Hypersensitivity - immunology</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin E - blood</topic><topic>Life Sciences</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Prospective Studies</topic><topic>Research Design</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Time Factors</topic><topic>Tumors</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calboli, Federico C. F.</creatorcontrib><creatorcontrib>Cox, David G.</creatorcontrib><creatorcontrib>Buring, Julie E.</creatorcontrib><creatorcontrib>Gaziano, J. Michael</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Stampfer, Meir</creatorcontrib><creatorcontrib>Willett, Walter C.</creatorcontrib><creatorcontrib>Tworoger, Shelley S.</creatorcontrib><creatorcontrib>Hunter, David J.</creatorcontrib><creatorcontrib>Camargo, Carlos A.</creatorcontrib><creatorcontrib>Michaud, Dominique S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calboli, Federico C. F.</au><au>Cox, David G.</au><au>Buring, Julie E.</au><au>Gaziano, J. Michael</au><au>Ma, Jing</au><au>Stampfer, Meir</au><au>Willett, Walter C.</au><au>Tworoger, Shelley S.</au><au>Hunter, David J.</au><au>Camargo, Carlos A.</au><au>Michaud, Dominique S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediagnostic Plasma IgE Levels and Risk of Adult Glioma in Four Prospective Cohort Studies</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>J Natl Cancer Inst</addtitle><date>2011-11-02</date><risdate>2011</risdate><volume>103</volume><issue>21</issue><spage>1588</spage><epage>1595</epage><pages>1588-1595</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><coden>JNCIEQ</coden><abstract>Background
Increased levels of serum immunoglobulin E (IgE) because of allergies have been inversely associated with risk of glioma in observational studies. Despite consistency across studies examining history of allergies and glioma, questions remain as to whether those are causal associations. An inverse association between serum IgE and risk of glioma was reported in a large case-control study, but reverse causality and treatment effects remain potential explanations for those findings.
Methods
We combined data from four prospective cohort studies and used a nested case-control design to examine the association between allergy and glioma. We included glioma case subjects who were confirmed from medical or pathology records or from death certificates, and with prediagnostic blood available. We matched three control subjects per case subject, and the final numbers for analyses were 169 case subjects and 520 control subjects. Total IgE, food allergen-specific IgE, and respiratory allergen-specific IgE levels were measured using a highly sensitive fluorescent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression analysis. Stratified analyses were conducted by age and birth cohorts.
Results
Borderline elevated total IgE levels (25-100 kU/L) showed a statistically significant inverse association with glioma (OR = 0.63, 95% CI = 0.42 to 0.93), but no association was noted between elevated IgE (>100 kU/L) and glioma (OR = 0.98, 95% CI = 0.61 to 1.56) compared with clinically normal IgE levels (<25 kU/L). The association between glioma and total IgE was consistent for both men and women. Non-statistically significant inverse associations were noted for elevated IgE levels among individuals born before year 1930 (OR = 0.67, 95% CI = 0.34 to 1.34) and when restricting analyses to highly fatal (deceased within 2 years of diagnosis) glioma case subjects (OR = 0.64, 95% CI = 0.34 to 1.19) compared with individuals with clinically normal IgE levels. No associations were observed for either food allergen-specific or respiratory allergen-specific IgE levels.
Conclusions
Overall, our prospective findings are consistent with recent retrospective studies and support an association between total IgE levels and glioma. However, this association requires further elucidation.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>22010181</pmid><doi>10.1093/jnci/djr361</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | JNCI : Journal of the National Cancer Institute, 2011-11, Vol.103 (21), p.1588-1595 |
| issn | 0027-8874 1460-2105 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Allergens Allergens - immunology Allergies Asthma Asthma - complications Biological and medical sciences Brain Neoplasms Brain Neoplasms - diagnosis Brain Neoplasms - immunology Cancer Case-Control Studies Cohort Studies Female Glioma Glioma - diagnosis Glioma - immunology Humans Hypersensitivity Hypersensitivity - complications Hypersensitivity - immunology Immunoglobulin E Immunoglobulin E - blood Life Sciences Logistic Models Male Medical sciences Middle Aged Neurology Odds Ratio Prospective Studies Research Design Risk Assessment Risk Factors Studies Time Factors Tumors Tumors of the nervous system. Phacomatoses |
| title | Prediagnostic Plasma IgE Levels and Risk of Adult Glioma in Four Prospective Cohort Studies |
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