Transepithelial ion transport is suppressed in hypoxic sinonasal epithelium

Objectives/Hypothesis: Sinonasal respiratory epithelial mucociliary clearance is dependent on the transepithelial transport of ions such as Cl−. The objectives of the present study were to investigate the role of oxygen restriction in 1) Cl− transport across primary sinonasal epithelial monolayers,...

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Veröffentlicht in:	The Laryngoscope 2011-09, Vol.121 (9), p.1929-1934
Hauptverfasser:	Blount, Angela, Zhang, Shaoyan, Chestnut, Michael, Hixon, Brian, Skinner, Daniel, Sorscher, Eric J., Woodworth, Bradford A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anoctamin-1 Biological and medical sciences Biological Transport, Active - physiology Blotting, Western calcium-activated chloride channel CFTR Chloride Channels chloride secretion chronic sinusitis Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Epithelial Cells - metabolism Fluorescent Antibody Technique Gene Expression human sinus epithelium Humans hypoxia Hypoxia - metabolism In Vitro Techniques Ion Transport - physiology Level of Evidence: 1b Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism Mice mucociliary clearance murine nasal culture Nasal Septum - cytology Nasal Septum - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Non tumoral diseases Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Reverse Transcriptase Polymerase Chain Reaction TMEM16A Transepithelial ion transport
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