Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

Inclusions composed of α-synuclein (α-syn), i.e., Lewy bodies (LBs) and Lewy neurites (LNs), define synucleinopathies including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Here, we demonstrate that preformed fibrils generated from full-length and truncated recombinant α-syn en...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2011-10, Vol.72 (1), p.57-71
Hauptverfasser:	Volpicelli-Daley, Laura A., Luk, Kelvin C., Patel, Tapan P., Tanik, Selcuk A., Riddle, Dawn M., Stieber, Anna, Meaney, David F., Trojanowski, John Q., Lee, Virginia M.-Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - adverse effects alpha-Synuclein - metabolism Animals Axonal Transport - physiology Cell Death - physiology Endocytosis - physiology Hippocampus - metabolism Hippocampus - pathology Hippocampus - physiology Hippocampus - ultrastructure Humans Lewy Bodies - metabolism Lewy Bodies - pathology Mice Mice, Inbred C57BL Nerve Degeneration - metabolism Nerve Degeneration - pathology Nerve Tissue Proteins - metabolism Neurites - metabolism Neurites - pathology Neurons - metabolism Neurons - pathology Neurons - physiology Neurons - ultrastructure Primary Cell Culture Synapses - metabolism Synapses - pathology Voltage-Sensitive Dye Imaging - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!