Evaluation of the Botanical Authenticity and Phytochemical Profile of Black Cohosh Products by High-Performance Liquid Chromatography with Selected Ion Monitoring Liquid Chromatography−Mass Spectrometry
Black cohosh (Actaea racemosa L., syn. Cimicifuga racemosa L.) has become increasingly popular as a dietary supplement in the United States for the treatment of symptoms related to menopause, but the botanical authenticity of most products containing black cohosh has not been evaluated, nor is manuf...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2006-05, Vol.54 (9), p.3242-3253 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Jiang, Bei Kronenberg, Fredi Nuntanakorn, Paiboon Qiu, Ming-Hua Kennelly, Edward J |
| description | Black cohosh (Actaea racemosa L., syn. Cimicifuga racemosa L.) has become increasingly popular as a dietary supplement in the United States for the treatment of symptoms related to menopause, but the botanical authenticity of most products containing black cohosh has not been evaluated, nor is manufacturing highly regulated in the United States. In this study, 11 black cohosh products were analyzed for triterpene glycosides, phenolic constituents, and formononetin by high-performance liquid chromatography−photodiode array detection and a new selected ion monitoring liquid chromatography−mass spectrometry method. Three of the 11 products were found to contain the marker compound cimifugin and not cimiracemoside C, thereby indicating that these plants contain Asian Actaea instead of black cohosh. One product contained both black cohosh and an Asian Actaea species. For the products containing only black cohosh, there was significant product-to-product variability in the amounts of the selected triterpene glycosides and phenolic constituents, and as expected, no formononetin was detected. Keywords: Black cohosh; dietary supplements; quality control; triterpene glycosides; phenolic constituents; formononetin; Actaea racemosa; Cimicifuga racemosa; Asian Actaea species |
| doi_str_mv | 10.1021/jf0606149 |
| format | Article |
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Cimicifuga racemosa L.) has become increasingly popular as a dietary supplement in the United States for the treatment of symptoms related to menopause, but the botanical authenticity of most products containing black cohosh has not been evaluated, nor is manufacturing highly regulated in the United States. In this study, 11 black cohosh products were analyzed for triterpene glycosides, phenolic constituents, and formononetin by high-performance liquid chromatography−photodiode array detection and a new selected ion monitoring liquid chromatography−mass spectrometry method. Three of the 11 products were found to contain the marker compound cimifugin and not cimiracemoside C, thereby indicating that these plants contain Asian Actaea instead of black cohosh. One product contained both black cohosh and an Asian Actaea species. For the products containing only black cohosh, there was significant product-to-product variability in the amounts of the selected triterpene glycosides and phenolic constituents, and as expected, no formononetin was detected. Keywords: Black cohosh; dietary supplements; quality control; triterpene glycosides; phenolic constituents; formononetin; Actaea racemosa; Cimicifuga racemosa; Asian Actaea species</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf0606149</identifier><identifier>PMID: 16637680</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Actaea racemosa ; Biological and medical sciences ; Chromatography, High Pressure Liquid - methods ; Cimicifuga - chemistry ; dietary supplements ; Drug Contamination ; Feeding. Feeding behavior ; Food industries ; formononetin ; Fundamental and applied biological sciences. Psychology ; General aspects ; glycosides ; Glycosides - analysis ; high performance liquid chromatography ; Isoflavones - analysis ; liquid chromatography ; mass spectrometry ; Mass Spectrometry - methods ; Methods of analysis, processing and quality control, regulation, standards ; phenolic compounds ; Phenols - analysis ; product authenticity ; Reproducibility of Results ; selected ion monitoring liquid chromatography ; triterpene glycosides ; Triterpenes - analysis ; triterpenoids ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of agricultural and food chemistry, 2006-05, Vol.54 (9), p.3242-3253</ispartof><rights>Copyright © 2006 American Chemical Society</rights><rights>2006 INIST-CNRS</rights><rights>2006 American Chemical Society 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a495t-8bb65f1fa285bc08e101b95476893cdf1e83b1d84c55b0a57d9c29888b3ecdfd3</citedby><cites>FETCH-LOGICAL-a495t-8bb65f1fa285bc08e101b95476893cdf1e83b1d84c55b0a57d9c29888b3ecdfd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf0606149$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf0606149$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,780,784,885,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17803597$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16637680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Bei</creatorcontrib><creatorcontrib>Kronenberg, Fredi</creatorcontrib><creatorcontrib>Nuntanakorn, Paiboon</creatorcontrib><creatorcontrib>Qiu, Ming-Hua</creatorcontrib><creatorcontrib>Kennelly, Edward J</creatorcontrib><title>Evaluation of the Botanical Authenticity and Phytochemical Profile of Black Cohosh Products by High-Performance Liquid Chromatography with Selected Ion Monitoring Liquid Chromatography−Mass Spectrometry</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Black cohosh (Actaea racemosa L., syn. Cimicifuga racemosa L.) has become increasingly popular as a dietary supplement in the United States for the treatment of symptoms related to menopause, but the botanical authenticity of most products containing black cohosh has not been evaluated, nor is manufacturing highly regulated in the United States. In this study, 11 black cohosh products were analyzed for triterpene glycosides, phenolic constituents, and formononetin by high-performance liquid chromatography−photodiode array detection and a new selected ion monitoring liquid chromatography−mass spectrometry method. Three of the 11 products were found to contain the marker compound cimifugin and not cimiracemoside C, thereby indicating that these plants contain Asian Actaea instead of black cohosh. One product contained both black cohosh and an Asian Actaea species. For the products containing only black cohosh, there was significant product-to-product variability in the amounts of the selected triterpene glycosides and phenolic constituents, and as expected, no formononetin was detected. Keywords: Black cohosh; dietary supplements; quality control; triterpene glycosides; phenolic constituents; formononetin; Actaea racemosa; Cimicifuga racemosa; Asian Actaea species</description><subject>Actaea racemosa</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Cimicifuga - chemistry</subject><subject>dietary supplements</subject><subject>Drug Contamination</subject><subject>Feeding. Feeding behavior</subject><subject>Food industries</subject><subject>formononetin</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>glycosides</subject><subject>Glycosides - analysis</subject><subject>high performance liquid chromatography</subject><subject>Isoflavones - analysis</subject><subject>liquid chromatography</subject><subject>mass spectrometry</subject><subject>Mass Spectrometry - methods</subject><subject>Methods of analysis, processing and quality control, regulation, standards</subject><subject>phenolic compounds</subject><subject>Phenols - analysis</subject><subject>product authenticity</subject><subject>Reproducibility of Results</subject><subject>selected ion monitoring liquid chromatography</subject><subject>triterpene glycosides</subject><subject>Triterpenes - analysis</subject><subject>triterpenoids</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkcFu1DAQhiMEokvhwAuALyBxCNhJHDuXSu2q0EpbsWjbCxdr4jgbb5N4azuFvAFnnoun4EnwsqtdkHqy7P-bf8bzR9FLgt8TnJAPqxrnOCdZ8SiaEJrgmBLCH0cTHMSY05wcRc-cW2GMOWX4aXRE8jxlOceT6Nf5PbQDeG16ZGrkG4XOjIdeS2jR6RDuvddS-xFBX6F5M3ojG9X9lefW1LpVm7qzFuQtmprGuGbzXg3SO1SO6EIvm3iubG1sB71UaKbvBl2haWNNB94sLaybEX3TvkEL1SrpVYUuwzBXptfeWN0vHy75_ePnFTiHFutQEwTl7fg8elJD69SL3Xkc3Xw8v55exLPPny6np7MYsoL6mJdlTmtSQ8JpKTFXBJOyoFnYSJHKqiaKpyWpeCYpLTFQVhUyKTjnZaqCXKXH0cnWdz2Unapk2JGFVqyt7sCOwoAW_yu9bsTS3Is0wVnKcDB4uzOw5m5QzotOO6naFnplBidyVmBKizyA77agtMY5q-p9E4LFJnuxzz6wr_6d6kDuwg7Amx0ALuRX2xCIdgeOBYYWLHDxltPOq-97HextGCxlVFzPF-ILXmSEESa-Bv71lq_BCFja4HmzSDBJMcEsxQk7dAbpxMoMtg_xPPCFP8kq4hQ</recordid><startdate>20060503</startdate><enddate>20060503</enddate><creator>Jiang, Bei</creator><creator>Kronenberg, Fredi</creator><creator>Nuntanakorn, Paiboon</creator><creator>Qiu, Ming-Hua</creator><creator>Kennelly, Edward J</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060503</creationdate><title>Evaluation of the Botanical Authenticity and Phytochemical Profile of Black Cohosh Products by High-Performance Liquid Chromatography with Selected Ion Monitoring Liquid Chromatography−Mass Spectrometry</title><author>Jiang, Bei ; Kronenberg, Fredi ; Nuntanakorn, Paiboon ; Qiu, Ming-Hua ; Kennelly, Edward J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a495t-8bb65f1fa285bc08e101b95476893cdf1e83b1d84c55b0a57d9c29888b3ecdfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Actaea racemosa</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Cimicifuga - chemistry</topic><topic>dietary supplements</topic><topic>Drug Contamination</topic><topic>Feeding. Feeding behavior</topic><topic>Food industries</topic><topic>formononetin</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>glycosides</topic><topic>Glycosides - analysis</topic><topic>high performance liquid chromatography</topic><topic>Isoflavones - analysis</topic><topic>liquid chromatography</topic><topic>mass spectrometry</topic><topic>Mass Spectrometry - methods</topic><topic>Methods of analysis, processing and quality control, regulation, standards</topic><topic>phenolic compounds</topic><topic>Phenols - analysis</topic><topic>product authenticity</topic><topic>Reproducibility of Results</topic><topic>selected ion monitoring liquid chromatography</topic><topic>triterpene glycosides</topic><topic>Triterpenes - analysis</topic><topic>triterpenoids</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Bei</creatorcontrib><creatorcontrib>Kronenberg, Fredi</creatorcontrib><creatorcontrib>Nuntanakorn, Paiboon</creatorcontrib><creatorcontrib>Qiu, Ming-Hua</creatorcontrib><creatorcontrib>Kennelly, Edward J</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Bei</au><au>Kronenberg, Fredi</au><au>Nuntanakorn, Paiboon</au><au>Qiu, Ming-Hua</au><au>Kennelly, Edward J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Botanical Authenticity and Phytochemical Profile of Black Cohosh Products by High-Performance Liquid Chromatography with Selected Ion Monitoring Liquid Chromatography−Mass Spectrometry</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2006-05-03</date><risdate>2006</risdate><volume>54</volume><issue>9</issue><spage>3242</spage><epage>3253</epage><pages>3242-3253</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Black cohosh (Actaea racemosa L., syn. Cimicifuga racemosa L.) has become increasingly popular as a dietary supplement in the United States for the treatment of symptoms related to menopause, but the botanical authenticity of most products containing black cohosh has not been evaluated, nor is manufacturing highly regulated in the United States. In this study, 11 black cohosh products were analyzed for triterpene glycosides, phenolic constituents, and formononetin by high-performance liquid chromatography−photodiode array detection and a new selected ion monitoring liquid chromatography−mass spectrometry method. Three of the 11 products were found to contain the marker compound cimifugin and not cimiracemoside C, thereby indicating that these plants contain Asian Actaea instead of black cohosh. One product contained both black cohosh and an Asian Actaea species. For the products containing only black cohosh, there was significant product-to-product variability in the amounts of the selected triterpene glycosides and phenolic constituents, and as expected, no formononetin was detected. Keywords: Black cohosh; dietary supplements; quality control; triterpene glycosides; phenolic constituents; formononetin; Actaea racemosa; Cimicifuga racemosa; Asian Actaea species</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>16637680</pmid><doi>10.1021/jf0606149</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of agricultural and food chemistry, 2006-05, Vol.54 (9), p.3242-3253 |
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| subjects | Actaea racemosa Biological and medical sciences Chromatography, High Pressure Liquid - methods Cimicifuga - chemistry dietary supplements Drug Contamination Feeding. Feeding behavior Food industries formononetin Fundamental and applied biological sciences. Psychology General aspects glycosides Glycosides - analysis high performance liquid chromatography Isoflavones - analysis liquid chromatography mass spectrometry Mass Spectrometry - methods Methods of analysis, processing and quality control, regulation, standards phenolic compounds Phenols - analysis product authenticity Reproducibility of Results selected ion monitoring liquid chromatography triterpene glycosides Triterpenes - analysis triterpenoids Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Evaluation of the Botanical Authenticity and Phytochemical Profile of Black Cohosh Products by High-Performance Liquid Chromatography with Selected Ion Monitoring Liquid Chromatography−Mass Spectrometry |
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