Endogenous Angiogenesis Inhibitor Blocks Tumor Growth via Direct and Indirect Effects on Tumor Microenvironment

Tissue inhibitor of matrix metalloproteinase–2 (TIMP-2) belongs to a small family of endogenous proteins that inhibits a group of enzymes, the matrix metalloproteinases (MMPs). TIMP-2 inhibits endothelial cell proliferation and migration in vitro and angiogenesis in vivo , through MMP-dependent and...

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Veröffentlicht in:	The American journal of pathology 2011-11, Vol.179 (5), p.2589-2600
Hauptverfasser:	Bourboulia, Dimitra, Jensen-Taubman, Sandra, Rittler, Matthew R, Han, Hui Ying, Chatterjee, Tania, Wei, Beiyang, Stetler-Stevenson, William G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood supply Adenocarcinoma - enzymology Animals Apoptosis - physiology Biological and medical sciences Cell Movement Cell Proliferation Female Focal Adhesion Protein-Tyrosine Kinases - metabolism Humans Investigative techniques, diagnostic techniques (general aspects) Lung Neoplasms - blood supply Lung Neoplasms - enzymology Matrix Metalloproteinase Inhibitors Medical sciences Mice Mice, Nude Microvessels Neoplasm Invasiveness Neoplasm Transplantation Neovascularization, Pathologic - enzymology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proto-Oncogene Proteins c-akt - metabolism Regular Tissue Inhibitor of Metalloproteinase-2 - metabolism Tissue Inhibitor of Metalloproteinase-2 - physiology Transplantation, Heterologous Tumor Cells, Cultured Tumor Microenvironment - physiology
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