Novel function of keratins 5 and 14 in proliferation and differentiation of stratified epithelial cells

Keratins are cytoplasmic intermediate filament proteins preferentially expressed by epithelial tissues in a site-specific and differentiation-dependent manner. The complex network of keratin filaments in stratified epithelia is tightly regulated during squamous cell differentiation. Keratin 14 (K14)...

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Veröffentlicht in:	Molecular biology of the cell 2011-11, Vol.22 (21), p.4068-4078
Hauptverfasser:	Alam, Hunain, Sehgal, Lalit, Kundu, Samrat T, Dalal, Sorab N, Vaidya, Milind M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation - metabolism Cell Adhesion Cell Cycle Proteins - metabolism Cell Differentiation Cell Line, Tumor Cell Proliferation Enzyme Activation Epithelial Cells - metabolism Epithelial Cells - physiology Extracellular Matrix - metabolism Gene Knockdown Techniques HEK293 Cells Humans Interphase Keratin-14 - genetics Keratin-14 - metabolism Keratin-5 - genetics Keratin-5 - metabolism Mice Mice, Nude Microscopy, Fluorescence Neoplasm Transplantation Proto-Oncogene Proteins c-akt - metabolism Receptor, Notch1 - metabolism RNA Interference Signal Transduction
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