Progression of Tau Pathology in Cholinergic Basal Forebrain Neurons in Mild Cognitive Impairment and Alzheimer's Disease

Tau is a microtubule-associated protein that forms neurofibrillary tangles (NFTs) in the selective vulnerable long projection neurons of the cholinergic basal forebrain (CBF) in Alzheimer's disease (AD). Although CBF neurodegeneration correlates with cognitive decline during AD progression, lit...

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Veröffentlicht in:	The American journal of pathology 2011-11, Vol.179 (5), p.2533-2550
Hauptverfasser:	Vana, Laurel, Kanaan, Nicholas M, Ugwu, Isabella C, Wuu, Joanne, Mufson, Elliott J, Binder, Lester I
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - pathology Antibodies, Monoclonal - metabolism Biological and medical sciences Biomarkers - metabolism Cholinergic Neurons - pathology Cognitive Dysfunction - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Female Geriatrics Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Neurology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prosencephalon - pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Regular tau Proteins - immunology tau Proteins - metabolism
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