Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions
The nucleotide receptor P2X 7 is an attractive therapeutic target and potential biomarker for multiple inflammatory and neurologic disorders, and it is expressed in several immune, osteogenic, and neurologic cell types. Aside from its role in the nervous system, it is activated by ATP released at si...
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| Veröffentlicht in: | Immunologic research 2011-05, Vol.50 (1), p.22-38 |
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| creator | Lenertz, Lisa Y. Gavala, Monica L. Zhu, Yiming Bertics, Paul J. |
| description | The nucleotide receptor P2X
7
is an attractive therapeutic target and potential biomarker for multiple inflammatory and neurologic disorders, and it is expressed in several immune, osteogenic, and neurologic cell types. Aside from its role in the nervous system, it is activated by ATP released at sites of tissue damage, inflammation, and infection. Ligand binding to P2X
7
stimulates many cell responses, including calcium fluxes, MAPK activation, inflammatory mediator release, and apoptosis. Much work has centered on P2X
7
action in cell death and mediator processing (e.g., pro-interleukin-1 cleavage by the inflammasome), but the contribution of P2X
7
to transcriptional regulation is less well defined. This review will focus on the growing evidence for the importance of nucleotide-mediated gene expression, highlight several animal models, human genetic, and clinical studies that support P2X
7
as a therapeutic target, and discuss the latest developments in anti-P2X
7
clinical trials. |
| doi_str_mv | 10.1007/s12026-011-8203-4 |
| format | Article |
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7
is an attractive therapeutic target and potential biomarker for multiple inflammatory and neurologic disorders, and it is expressed in several immune, osteogenic, and neurologic cell types. Aside from its role in the nervous system, it is activated by ATP released at sites of tissue damage, inflammation, and infection. Ligand binding to P2X
7
stimulates many cell responses, including calcium fluxes, MAPK activation, inflammatory mediator release, and apoptosis. Much work has centered on P2X
7
action in cell death and mediator processing (e.g., pro-interleukin-1 cleavage by the inflammasome), but the contribution of P2X
7
to transcriptional regulation is less well defined. This review will focus on the growing evidence for the importance of nucleotide-mediated gene expression, highlight several animal models, human genetic, and clinical studies that support P2X
7
as a therapeutic target, and discuss the latest developments in anti-P2X
7
clinical trials.</description><identifier>ISSN: 0257-277X</identifier><identifier>EISSN: 1559-0755</identifier><identifier>DOI: 10.1007/s12026-011-8203-4</identifier><identifier>PMID: 21298493</identifier><language>eng</language><publisher>New York: Humana Press Inc</publisher><subject>Adenosine Triphosphate - metabolism ; Allergology ; Animal models ; Animals ; Apoptosis ; ATP ; biomarkers ; Biomarkers - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Calcium ; Cellular biology ; Clinical trials ; Gene expression ; Gene Expression Regulation ; Gene regulation ; Humans ; Immune system ; Immunologic Factors - immunology ; Immunology ; Infection ; Inflammation ; Inflammation - immunology ; Inflammatory diseases ; Interleukin-1beta - immunology ; Interleukin-1beta - metabolism ; Internal Medicine ; MAP kinase ; Medicine/Public Health ; Nervous system ; Nucleotides ; Osteogenesis - genetics ; Osteogenesis - immunology ; Proto-Oncogene Proteins c-fos - metabolism ; Receptors, Purinergic P2X7 - genetics ; Receptors, Purinergic P2X7 - immunology ; Signal Transduction - genetics ; Signal Transduction - immunology ; Transcription</subject><ispartof>Immunologic research, 2011-05, Vol.50 (1), p.22-38</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-103935173002d43f175144ff1d6a27be80ac4f565b2fbca2bd59d17b074a321d3</citedby><cites>FETCH-LOGICAL-c500t-103935173002d43f175144ff1d6a27be80ac4f565b2fbca2bd59d17b074a321d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12026-011-8203-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12026-011-8203-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21298493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lenertz, Lisa Y.</creatorcontrib><creatorcontrib>Gavala, Monica L.</creatorcontrib><creatorcontrib>Zhu, Yiming</creatorcontrib><creatorcontrib>Bertics, Paul J.</creatorcontrib><title>Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions</title><title>Immunologic research</title><addtitle>Immunol Res</addtitle><addtitle>Immunol Res</addtitle><description>The nucleotide receptor P2X
7
is an attractive therapeutic target and potential biomarker for multiple inflammatory and neurologic disorders, and it is expressed in several immune, osteogenic, and neurologic cell types. Aside from its role in the nervous system, it is activated by ATP released at sites of tissue damage, inflammation, and infection. Ligand binding to P2X
7
stimulates many cell responses, including calcium fluxes, MAPK activation, inflammatory mediator release, and apoptosis. Much work has centered on P2X
7
action in cell death and mediator processing (e.g., pro-interleukin-1 cleavage by the inflammasome), but the contribution of P2X
7
to transcriptional regulation is less well defined. This review will focus on the growing evidence for the importance of nucleotide-mediated gene expression, highlight several animal models, human genetic, and clinical studies that support P2X
7
as a therapeutic target, and discuss the latest developments in anti-P2X
7
clinical trials.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Allergology</subject><subject>Animal models</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>ATP</subject><subject>biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium</subject><subject>Cellular biology</subject><subject>Clinical trials</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Gene regulation</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunologic Factors - immunology</subject><subject>Immunology</subject><subject>Infection</subject><subject>Inflammation</subject><subject>Inflammation - immunology</subject><subject>Inflammatory diseases</subject><subject>Interleukin-1beta - immunology</subject><subject>Interleukin-1beta - metabolism</subject><subject>Internal Medicine</subject><subject>MAP kinase</subject><subject>Medicine/Public Health</subject><subject>Nervous system</subject><subject>Nucleotides</subject><subject>Osteogenesis - genetics</subject><subject>Osteogenesis - immunology</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Receptors, Purinergic P2X7 - genetics</subject><subject>Receptors, Purinergic P2X7 - immunology</subject><subject>Signal Transduction - genetics</subject><subject>Signal Transduction - immunology</subject><subject>Transcription</subject><issn>0257-277X</issn><issn>1559-0755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkstu1TAQhi0EoofCA7BBFhs2DYxvcbJBqqpykSrBokjdWY7j5LhK7IPtgHiVPi0OKeUiIVa29H_ze2b8I_SUwEsCIF8lQoHWFRBSNRRYxe-hHRGirUAKcR_tgApZUSmvjtCjlK4BSM05e4iOKKFtw1u2QzeXUftkojtkF7yesAk-xzDh2Zq99i7NCeuUgnE62x5_dXmP895iv5jJhux6i6M19pBDxB_plTzBGhe37EzxinZcJr1KYcBunhcfpjA6c4JDyjaM1q937Xvs7RI3DQ-LN2sv6TF6MOgp2Se35zH69Ob88uxddfHh7fuz04vKCIBcEWAtE0QyANpzNhApCOfDQPpaU9nZBrThg6hFR4fOaNr1ou2J7EByzSjp2TF6vfkelm62vbFlAXpSh-hmHb-poJ36U_Fur8bwRbGy85o1xeDFrUEMnxebsppdMnaatLdhSaoFzlsqyr7_RzY1l02hRSGf_0VehyWWD_oBQcMY5QUiG2RiSCna4a5pAmpNiNoSokpC1JoQtdY8-33au4qfkSgA3YBUJD_a-Ovlf7t-B-qOygw</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Lenertz, Lisa Y.</creator><creator>Gavala, Monica L.</creator><creator>Zhu, Yiming</creator><creator>Bertics, Paul J.</creator><general>Humana Press Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TM</scope><scope>5PM</scope></search><sort><creationdate>20110501</creationdate><title>Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions</title><author>Lenertz, Lisa Y. ; Gavala, Monica L. ; Zhu, Yiming ; Bertics, Paul J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-103935173002d43f175144ff1d6a27be80ac4f565b2fbca2bd59d17b074a321d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Allergology</topic><topic>Animal models</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>ATP</topic><topic>biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Calcium</topic><topic>Cellular biology</topic><topic>Clinical trials</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>Gene regulation</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunologic Factors - immunology</topic><topic>Immunology</topic><topic>Infection</topic><topic>Inflammation</topic><topic>Inflammation - immunology</topic><topic>Inflammatory diseases</topic><topic>Interleukin-1beta - immunology</topic><topic>Interleukin-1beta - metabolism</topic><topic>Internal Medicine</topic><topic>MAP kinase</topic><topic>Medicine/Public Health</topic><topic>Nervous system</topic><topic>Nucleotides</topic><topic>Osteogenesis - genetics</topic><topic>Osteogenesis - immunology</topic><topic>Proto-Oncogene Proteins c-fos - metabolism</topic><topic>Receptors, Purinergic P2X7 - genetics</topic><topic>Receptors, Purinergic P2X7 - immunology</topic><topic>Signal Transduction - genetics</topic><topic>Signal Transduction - immunology</topic><topic>Transcription</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lenertz, Lisa Y.</creatorcontrib><creatorcontrib>Gavala, Monica L.</creatorcontrib><creatorcontrib>Zhu, Yiming</creatorcontrib><creatorcontrib>Bertics, Paul J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunologic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lenertz, Lisa Y.</au><au>Gavala, Monica L.</au><au>Zhu, Yiming</au><au>Bertics, Paul J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions</atitle><jtitle>Immunologic research</jtitle><stitle>Immunol Res</stitle><addtitle>Immunol Res</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>50</volume><issue>1</issue><spage>22</spage><epage>38</epage><pages>22-38</pages><issn>0257-277X</issn><eissn>1559-0755</eissn><abstract>The nucleotide receptor P2X
7
is an attractive therapeutic target and potential biomarker for multiple inflammatory and neurologic disorders, and it is expressed in several immune, osteogenic, and neurologic cell types. Aside from its role in the nervous system, it is activated by ATP released at sites of tissue damage, inflammation, and infection. Ligand binding to P2X
7
stimulates many cell responses, including calcium fluxes, MAPK activation, inflammatory mediator release, and apoptosis. Much work has centered on P2X
7
action in cell death and mediator processing (e.g., pro-interleukin-1 cleavage by the inflammasome), but the contribution of P2X
7
to transcriptional regulation is less well defined. This review will focus on the growing evidence for the importance of nucleotide-mediated gene expression, highlight several animal models, human genetic, and clinical studies that support P2X
7
as a therapeutic target, and discuss the latest developments in anti-P2X
7
clinical trials.</abstract><cop>New York</cop><pub>Humana Press Inc</pub><pmid>21298493</pmid><doi>10.1007/s12026-011-8203-4</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Immunologic research, 2011-05, Vol.50 (1), p.22-38 |
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| subjects | Adenosine Triphosphate - metabolism Allergology Animal models Animals Apoptosis ATP biomarkers Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Calcium Cellular biology Clinical trials Gene expression Gene Expression Regulation Gene regulation Humans Immune system Immunologic Factors - immunology Immunology Infection Inflammation Inflammation - immunology Inflammatory diseases Interleukin-1beta - immunology Interleukin-1beta - metabolism Internal Medicine MAP kinase Medicine/Public Health Nervous system Nucleotides Osteogenesis - genetics Osteogenesis - immunology Proto-Oncogene Proteins c-fos - metabolism Receptors, Purinergic P2X7 - genetics Receptors, Purinergic P2X7 - immunology Signal Transduction - genetics Signal Transduction - immunology Transcription |
| title | Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions |
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