General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain

Clinically used general anesthetics, alone or in combination, are damaging to the developing mammalian brain. In addition to causing widespread apoptotic neurodegeneration in vulnerable brain regions, exposure to general anesthesia at the peak of synaptogenesis causes learning and memory deficiencie...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2011-11, Vol.115 (5), p.992-1002
Hauptverfasser:	SANCHEZ, Victoria, FEINSTEIN, Shawn D, LUNARDI, Nadia, JOKSOVIC, Pavle M, BOSCOLO, Annalisa, TODOROVIC, Slobodan M, JEVTOVIC-TODOROVIC, Vesna
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesia, General - adverse effects Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics Anesthetics, General - toxicity Animals Apoptosis Biological and medical sciences Brain Brain - drug effects Brain - embryology Cytochrome-c oxidase Electron transport chain Hippocampus Injuries Isoflurane Learning Long-term effects Medical sciences Memory Mitochondria Mitochondria - drug effects Mitochondria - ultrastructure Morphogenesis Morphogenesis - drug effects Neurodegeneration Neurotransmission Nitrous oxide Rats Rats, Sprague-Dawley Synaptic transmission Synaptic Transmission - drug effects Synaptogenesis
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