Hemoglobin S and C Heterozygosity Enhances Neither the Magnitude nor Breadth of Antibody Responses to a Diverse Array of Plasmodium falciparum Antigens
Background. Heterozygous states of hemoglobin (Hb) A and HbS (HbAS, sickle-cell trait) or HbC (HbAC) protect against Plasmodium faldparum malaria by unclear mechanisms. Several studies suggest that HbAS and HbAC accelerate the acquisition of immunity to malaria, possibly by enhancing P. falaparum-sp...
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| creator | Tan, Xiaolin Traore, Boubacar Kayentao, Kassoum Ongoiba, Aissata Doumbo, Safiatou Waisberg, Michael Doumbo, Ogobara K. Felgner, Philip L. Fairhurst, Rick M. Crompton, Peter D. |
| description | Background. Heterozygous states of hemoglobin (Hb) A and HbS (HbAS, sickle-cell trait) or HbC (HbAC) protect against Plasmodium faldparum malaria by unclear mechanisms. Several studies suggest that HbAS and HbAC accelerate the acquisition of immunity to malaria, possibly by enhancing P. falaparum-specinc antibody responses. Methods. We used a protein microarray representing 491 P. falciparum proteins expressed during exoerythrocytic and erythrocytic stages of the life cycle to test the hypothesis that HbAS and HbAC enhance the P. falciparum-specific IgG response compared with normal HbAA. Plasma samples were collected from Malian children aged 2-10 years before and after a 6-month malaria season and were probed against the microarray. Immunoglobulin G (IgG) profiles of children with HbAA (n = 106), HbAS (n = 15), and HbAC (n = 20) were compared. Results. Although the magnitude and breadth of P. falciparum-specific IgG responses increased with age and from before to after the malaria season in each antigen category, Hb type did not independently predict significant differences in P. falciparum-specific IgG profiles. Conclusions. These data do not support the hypothesis that HbAS and HbAC protect against malaria by enhancing P. falciparum-specific antibody responses. It remains possible that HbAS and HbAC protect against malaria by enhancing antibody responses to antigens not studied here or through other immune mechanisms. |
| doi_str_mv | 10.1093/infdis/jir638 |
| format | Article |
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Heterozygous states of hemoglobin (Hb) A and HbS (HbAS, sickle-cell trait) or HbC (HbAC) protect against Plasmodium faldparum malaria by unclear mechanisms. Several studies suggest that HbAS and HbAC accelerate the acquisition of immunity to malaria, possibly by enhancing P. falaparum-specinc antibody responses. Methods. We used a protein microarray representing 491 P. falciparum proteins expressed during exoerythrocytic and erythrocytic stages of the life cycle to test the hypothesis that HbAS and HbAC enhance the P. falciparum-specific IgG response compared with normal HbAA. Plasma samples were collected from Malian children aged 2-10 years before and after a 6-month malaria season and were probed against the microarray. Immunoglobulin G (IgG) profiles of children with HbAA (n = 106), HbAS (n = 15), and HbAC (n = 20) were compared. Results. Although the magnitude and breadth of P. falciparum-specific IgG responses increased with age and from before to after the malaria season in each antigen category, Hb type did not independently predict significant differences in P. falciparum-specific IgG profiles. Conclusions. These data do not support the hypothesis that HbAS and HbAC protect against malaria by enhancing P. falciparum-specific antibody responses. It remains possible that HbAS and HbAC protect against malaria by enhancing antibody responses to antigens not studied here or through other immune mechanisms.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jir638</identifier><identifier>PMID: 21998476</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Age Factors ; Animals ; Antibodies ; Antibodies, Protozoan - blood ; Antigens ; Antigens, Protozoan - immunology ; Biological and medical sciences ; Blood ; Child ; Child, Preschool ; Falciparum malaria ; Female ; Fundamental and applied biological sciences. Psychology ; Hemoglobin A - immunology ; Hemoglobin C - genetics ; Hemoglobin C - immunology ; Hemoglobin, Sickle - genetics ; Hemoglobin, Sickle - immunology ; Hemoglobins ; Heterozygote ; Humans ; Immunity ; Immunoglobulin G - blood ; Infections ; Infectious diseases ; Life Cycle Stages - immunology ; Life cycle. Host-agent relationship. Pathogenesis ; Major and Brief Reports ; Malaria ; Malaria, Falciparum - immunology ; Malaria, Falciparum - parasitology ; Male ; Mali ; Medical sciences ; Microbiology ; PARASITES ; Plasmodium falciparum - growth & development ; Plasmodium falciparum - immunology ; Protein Array Analysis ; Protozoa ; Reactivity ; Sickle cell trait</subject><ispartof>The Journal of infectious diseases, 2011-12, Vol.204 (11), p.1750-1761</ispartof><rights>Copyright © 2011 Oxford University Press</rights><rights>Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2011. 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-9c86a164c050d1f4cbf6decf9b9fd6f03ccc93b28739fa0658158948166384f43</citedby><cites>FETCH-LOGICAL-c471t-9c86a164c050d1f4cbf6decf9b9fd6f03ccc93b28739fa0658158948166384f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41329925$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41329925$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,777,781,800,882,1579,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25250703$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21998476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Xiaolin</creatorcontrib><creatorcontrib>Traore, Boubacar</creatorcontrib><creatorcontrib>Kayentao, Kassoum</creatorcontrib><creatorcontrib>Ongoiba, Aissata</creatorcontrib><creatorcontrib>Doumbo, Safiatou</creatorcontrib><creatorcontrib>Waisberg, Michael</creatorcontrib><creatorcontrib>Doumbo, Ogobara K.</creatorcontrib><creatorcontrib>Felgner, Philip L.</creatorcontrib><creatorcontrib>Fairhurst, Rick M.</creatorcontrib><creatorcontrib>Crompton, Peter D.</creatorcontrib><title>Hemoglobin S and C Heterozygosity Enhances Neither the Magnitude nor Breadth of Antibody Responses to a Diverse Array of Plasmodium falciparum Antigens</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Background. Heterozygous states of hemoglobin (Hb) A and HbS (HbAS, sickle-cell trait) or HbC (HbAC) protect against Plasmodium faldparum malaria by unclear mechanisms. Several studies suggest that HbAS and HbAC accelerate the acquisition of immunity to malaria, possibly by enhancing P. falaparum-specinc antibody responses. Methods. We used a protein microarray representing 491 P. falciparum proteins expressed during exoerythrocytic and erythrocytic stages of the life cycle to test the hypothesis that HbAS and HbAC enhance the P. falciparum-specific IgG response compared with normal HbAA. Plasma samples were collected from Malian children aged 2-10 years before and after a 6-month malaria season and were probed against the microarray. Immunoglobulin G (IgG) profiles of children with HbAA (n = 106), HbAS (n = 15), and HbAC (n = 20) were compared. Results. Although the magnitude and breadth of P. falciparum-specific IgG responses increased with age and from before to after the malaria season in each antigen category, Hb type did not independently predict significant differences in P. falciparum-specific IgG profiles. Conclusions. These data do not support the hypothesis that HbAS and HbAC protect against malaria by enhancing P. falciparum-specific antibody responses. It remains possible that HbAS and HbAC protect against malaria by enhancing antibody responses to antigens not studied here or through other immune mechanisms.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Protozoan - blood</subject><subject>Antigens</subject><subject>Antigens, Protozoan - immunology</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Falciparum malaria</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemoglobin A - immunology</subject><subject>Hemoglobin C - genetics</subject><subject>Hemoglobin C - immunology</subject><subject>Hemoglobin, Sickle - genetics</subject><subject>Hemoglobin, Sickle - immunology</subject><subject>Hemoglobins</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunoglobulin G - blood</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Life Cycle Stages - immunology</subject><subject>Life cycle. Host-agent relationship. Pathogenesis</subject><subject>Major and Brief Reports</subject><subject>Malaria</subject><subject>Malaria, Falciparum - immunology</subject><subject>Malaria, Falciparum - parasitology</subject><subject>Male</subject><subject>Mali</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>PARASITES</subject><subject>Plasmodium falciparum - growth & development</subject><subject>Plasmodium falciparum - immunology</subject><subject>Protein Array Analysis</subject><subject>Protozoa</subject><subject>Reactivity</subject><subject>Sickle cell trait</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2P1CAYxonRuOPo0aOGi9FLXSiUlovJOLs6JutH_Dg3lEKHSQsV6Cb1H9l_VyYdJ3oyJC_k5fe8D-EB4ClGrzHi5NJY3ZpweTCekeoeWOGClBljmNwHK4TyPMMV5xfgUQgHhBAlrHwILnLMeUVLtgJ3OzW4rneNsfAbFLaFW7hTUXn3a-5cMHGG13YvrFQBflIm7pWHqcCPorMmTq2C1nn41ivRxj10Gm5sNI1rZ_hVhdHZkHTRQQGvzK3yQcGN92I-gl96EQbXmmmAWvTSjMKn41HeKRsegwepG9ST074GP95df9_uspvP7z9sNzeZpCWOGZcVE5hRiQrUYk1lo1mrpOYN1y3TiEgpOWnyqiRcC8SKChcVpxVm6beopmQN3ixzx6kZVCuVjV709ejNIPxcO2Hqf2-s2dedu61Jjkie1hq8PA3w7uekQqwHE6Tqe2GVm0LNESaoRLRIZLaQ0rsQvNJnF4zqY5b1kmW9ZJn4538_7Uz_CS8BL06ACFL02qeYkvzMFXmRnEniXi2cm8b_ej5b0EOIzp9hiknOeV6Q3_CDxIo</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Tan, Xiaolin</creator><creator>Traore, Boubacar</creator><creator>Kayentao, Kassoum</creator><creator>Ongoiba, Aissata</creator><creator>Doumbo, Safiatou</creator><creator>Waisberg, Michael</creator><creator>Doumbo, Ogobara K.</creator><creator>Felgner, Philip L.</creator><creator>Fairhurst, Rick M.</creator><creator>Crompton, Peter D.</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111201</creationdate><title>Hemoglobin S and C Heterozygosity Enhances Neither the Magnitude nor Breadth of Antibody Responses to a Diverse Array of Plasmodium falciparum Antigens</title><author>Tan, Xiaolin ; Traore, Boubacar ; Kayentao, Kassoum ; Ongoiba, Aissata ; Doumbo, Safiatou ; Waisberg, Michael ; Doumbo, Ogobara K. ; Felgner, Philip L. ; Fairhurst, Rick M. ; Crompton, Peter D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-9c86a164c050d1f4cbf6decf9b9fd6f03ccc93b28739fa0658158948166384f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Protozoan - blood</topic><topic>Antigens</topic><topic>Antigens, Protozoan - immunology</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Falciparum malaria</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemoglobin A - immunology</topic><topic>Hemoglobin C - genetics</topic><topic>Hemoglobin C - immunology</topic><topic>Hemoglobin, Sickle - genetics</topic><topic>Hemoglobin, Sickle - immunology</topic><topic>Hemoglobins</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Immunity</topic><topic>Immunoglobulin G - blood</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Life Cycle Stages - immunology</topic><topic>Life cycle. Host-agent relationship. Pathogenesis</topic><topic>Major and Brief Reports</topic><topic>Malaria</topic><topic>Malaria, Falciparum - immunology</topic><topic>Malaria, Falciparum - parasitology</topic><topic>Male</topic><topic>Mali</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>PARASITES</topic><topic>Plasmodium falciparum - growth & development</topic><topic>Plasmodium falciparum - immunology</topic><topic>Protein Array Analysis</topic><topic>Protozoa</topic><topic>Reactivity</topic><topic>Sickle cell trait</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Xiaolin</creatorcontrib><creatorcontrib>Traore, Boubacar</creatorcontrib><creatorcontrib>Kayentao, Kassoum</creatorcontrib><creatorcontrib>Ongoiba, Aissata</creatorcontrib><creatorcontrib>Doumbo, Safiatou</creatorcontrib><creatorcontrib>Waisberg, Michael</creatorcontrib><creatorcontrib>Doumbo, Ogobara K.</creatorcontrib><creatorcontrib>Felgner, Philip L.</creatorcontrib><creatorcontrib>Fairhurst, Rick M.</creatorcontrib><creatorcontrib>Crompton, Peter D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Xiaolin</au><au>Traore, Boubacar</au><au>Kayentao, Kassoum</au><au>Ongoiba, Aissata</au><au>Doumbo, Safiatou</au><au>Waisberg, Michael</au><au>Doumbo, Ogobara K.</au><au>Felgner, Philip L.</au><au>Fairhurst, Rick M.</au><au>Crompton, Peter D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemoglobin S and C Heterozygosity Enhances Neither the Magnitude nor Breadth of Antibody Responses to a Diverse Array of Plasmodium falciparum Antigens</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>204</volume><issue>11</issue><spage>1750</spage><epage>1761</epage><pages>1750-1761</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Background. Heterozygous states of hemoglobin (Hb) A and HbS (HbAS, sickle-cell trait) or HbC (HbAC) protect against Plasmodium faldparum malaria by unclear mechanisms. Several studies suggest that HbAS and HbAC accelerate the acquisition of immunity to malaria, possibly by enhancing P. falaparum-specinc antibody responses. Methods. We used a protein microarray representing 491 P. falciparum proteins expressed during exoerythrocytic and erythrocytic stages of the life cycle to test the hypothesis that HbAS and HbAC enhance the P. falciparum-specific IgG response compared with normal HbAA. Plasma samples were collected from Malian children aged 2-10 years before and after a 6-month malaria season and were probed against the microarray. Immunoglobulin G (IgG) profiles of children with HbAA (n = 106), HbAS (n = 15), and HbAC (n = 20) were compared. Results. Although the magnitude and breadth of P. falciparum-specific IgG responses increased with age and from before to after the malaria season in each antigen category, Hb type did not independently predict significant differences in P. falciparum-specific IgG profiles. Conclusions. These data do not support the hypothesis that HbAS and HbAC protect against malaria by enhancing P. falciparum-specific antibody responses. It remains possible that HbAS and HbAC protect against malaria by enhancing antibody responses to antigens not studied here or through other immune mechanisms.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21998476</pmid><doi>10.1093/infdis/jir638</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Animals Antibodies Antibodies, Protozoan - blood Antigens Antigens, Protozoan - immunology Biological and medical sciences Blood Child Child, Preschool Falciparum malaria Female Fundamental and applied biological sciences. Psychology Hemoglobin A - immunology Hemoglobin C - genetics Hemoglobin C - immunology Hemoglobin, Sickle - genetics Hemoglobin, Sickle - immunology Hemoglobins Heterozygote Humans Immunity Immunoglobulin G - blood Infections Infectious diseases Life Cycle Stages - immunology Life cycle. Host-agent relationship. Pathogenesis Major and Brief Reports Malaria Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Male Mali Medical sciences Microbiology PARASITES Plasmodium falciparum - growth & development Plasmodium falciparum - immunology Protein Array Analysis Protozoa Reactivity Sickle cell trait |
| title | Hemoglobin S and C Heterozygosity Enhances Neither the Magnitude nor Breadth of Antibody Responses to a Diverse Array of Plasmodium falciparum Antigens |
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