Omega-3 fatty acid deficiency selectively up-regulates delta6-desaturase expression and activity indices in rat liver: prevention by normalization of omega-3 fatty acid status
Abstract This study investigated the effects of perinatal dietary omega-3 ( n -3) fatty acid depletion and subsequent repletion on the expression of genes that regulate long-chain (LC) polyunsaturated fatty acid biosynthesis in rat liver and brain. It was hypothesized that chronic n -3 fatty acid de...
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| Veröffentlicht in: | Nutrition research (New York, N.Y.) N.Y.), 2011-09, Vol.31 (9), p.715-722 |
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| creator | Hofacer, Rylon Jandacek, Ronald Rider, Therese Tso, Patrick Magrisso, I. Jack Benoit, Stephen C McNamara, Robert K |
| description | Abstract This study investigated the effects of perinatal dietary omega-3 ( n -3) fatty acid depletion and subsequent repletion on the expression of genes that regulate long-chain (LC) polyunsaturated fatty acid biosynthesis in rat liver and brain. It was hypothesized that chronic n -3 fatty acid deficiency would increase liver Fads1 and Fads2 messenger RNA (mRNA) expression/activity and that n -3 fatty acid repletion would normalize this response. Adult rats fed the n -3–free diet during perinatal development exhibited significantly lower erythrocyte, liver, and frontal cortex LC n -3 fatty acid composition and reciprocal elevations in LC omega-6 ( n -6) fatty acid composition compared with controls (CONs) and repleted rats. Liver Fads2 , but not Fads1 , Elovl2 , or Elovl5 , mRNA expression was significantly greater in n- 3–deficient (DEF) rats compared with CONs and was partially normalized in repleted rats. The liver 18:3 n -6/18:2 n -6 ratio, an index of delta6-desturase activity, was significantly greater in DEF rats compared with CON and repleted rats and was positively correlated with Fads2 mRNA expression among all rats. The liver 18:3 n -6/18:2 n -6 ratio, but not Fads2 mRNA expression, was also positively correlated with erythrocyte and frontal cortex LC n -6 fatty acid compositions. Neither Fads1 or Fads2 mRNA expression was altered in brain cortex of DEF rats. These results confirm previous findings that liver, but not brain, delta6-desaturase expression and activity indices are negatively regulated by dietary n -3 fatty acids. |
| doi_str_mv | 10.1016/j.nutres.2011.08.007 |
| format | Article |
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Jack ; Benoit, Stephen C ; McNamara, Robert K</creator><creatorcontrib>Hofacer, Rylon ; Jandacek, Ronald ; Rider, Therese ; Tso, Patrick ; Magrisso, I. Jack ; Benoit, Stephen C ; McNamara, Robert K</creatorcontrib><description>Abstract This study investigated the effects of perinatal dietary omega-3 ( n -3) fatty acid depletion and subsequent repletion on the expression of genes that regulate long-chain (LC) polyunsaturated fatty acid biosynthesis in rat liver and brain. It was hypothesized that chronic n -3 fatty acid deficiency would increase liver Fads1 and Fads2 messenger RNA (mRNA) expression/activity and that n -3 fatty acid repletion would normalize this response. Adult rats fed the n -3–free diet during perinatal development exhibited significantly lower erythrocyte, liver, and frontal cortex LC n -3 fatty acid composition and reciprocal elevations in LC omega-6 ( n -6) fatty acid composition compared with controls (CONs) and repleted rats. Liver Fads2 , but not Fads1 , Elovl2 , or Elovl5 , mRNA expression was significantly greater in n- 3–deficient (DEF) rats compared with CONs and was partially normalized in repleted rats. The liver 18:3 n -6/18:2 n -6 ratio, an index of delta6-desturase activity, was significantly greater in DEF rats compared with CON and repleted rats and was positively correlated with Fads2 mRNA expression among all rats. The liver 18:3 n -6/18:2 n -6 ratio, but not Fads2 mRNA expression, was also positively correlated with erythrocyte and frontal cortex LC n -6 fatty acid compositions. Neither Fads1 or Fads2 mRNA expression was altered in brain cortex of DEF rats. These results confirm previous findings that liver, but not brain, delta6-desaturase expression and activity indices are negatively regulated by dietary n -3 fatty acids.</description><identifier>ISSN: 0271-5317</identifier><identifier>EISSN: 1879-0739</identifier><identifier>DOI: 10.1016/j.nutres.2011.08.007</identifier><identifier>PMID: 22024496</identifier><identifier>CODEN: NTRSDC</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acetyltransferases ; Acetyltransferases - genetics ; Acetyltransferases - metabolism ; administration & dosage ; adults ; Animals ; Biological and medical sciences ; biosynthesis ; blood ; brain ; Brain - metabolism ; correlation ; cortex ; Delta5-desaturase ( Fads1) ; Delta6-desaturase ( Fads2) ; Diet ; Elongase-2/5 ( Elovl2, Elovl5) ; Erythrocyte ; erythrocytes ; fatty acid composition ; Fatty Acids, Omega-3 ; Fatty Acids, Omega-3 - administration & dosage ; Fatty Acids, Omega-3 - blood ; Feeding. Feeding behavior ; Female ; Frontal cortex ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; gene expression ; genetics ; Linoleoyl-CoA Desaturase ; Linoleoyl-CoA Desaturase - genetics ; Linoleoyl-CoA Desaturase - metabolism ; Liver ; Liver - metabolism ; Male ; messenger RNA ; metabolism ; Omega-3 fatty acid ; omega-3 fatty acids ; polyunsaturated fatty acids ; Rat ; Rats ; repletion ; RNA, Messenger ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Up-Regulation ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Nutrition research (New York, N.Y.), 2011-09, Vol.31 (9), p.715-722</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>2011 Elsevier Inc. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c580t-c853716c6ebdf6b80a47d7bc4a86b4e50a901ff5534692d7f3bf329f09d307fa3</citedby><cites>FETCH-LOGICAL-c580t-c853716c6ebdf6b80a47d7bc4a86b4e50a901ff5534692d7f3bf329f09d307fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0271531711001539$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24720140$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22024496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hofacer, Rylon</creatorcontrib><creatorcontrib>Jandacek, Ronald</creatorcontrib><creatorcontrib>Rider, Therese</creatorcontrib><creatorcontrib>Tso, Patrick</creatorcontrib><creatorcontrib>Magrisso, I. Jack</creatorcontrib><creatorcontrib>Benoit, Stephen C</creatorcontrib><creatorcontrib>McNamara, Robert K</creatorcontrib><title>Omega-3 fatty acid deficiency selectively up-regulates delta6-desaturase expression and activity indices in rat liver: prevention by normalization of omega-3 fatty acid status</title><title>Nutrition research (New York, N.Y.)</title><addtitle>Nutr Res</addtitle><description>Abstract This study investigated the effects of perinatal dietary omega-3 ( n -3) fatty acid depletion and subsequent repletion on the expression of genes that regulate long-chain (LC) polyunsaturated fatty acid biosynthesis in rat liver and brain. It was hypothesized that chronic n -3 fatty acid deficiency would increase liver Fads1 and Fads2 messenger RNA (mRNA) expression/activity and that n -3 fatty acid repletion would normalize this response. Adult rats fed the n -3–free diet during perinatal development exhibited significantly lower erythrocyte, liver, and frontal cortex LC n -3 fatty acid composition and reciprocal elevations in LC omega-6 ( n -6) fatty acid composition compared with controls (CONs) and repleted rats. Liver Fads2 , but not Fads1 , Elovl2 , or Elovl5 , mRNA expression was significantly greater in n- 3–deficient (DEF) rats compared with CONs and was partially normalized in repleted rats. The liver 18:3 n -6/18:2 n -6 ratio, an index of delta6-desturase activity, was significantly greater in DEF rats compared with CON and repleted rats and was positively correlated with Fads2 mRNA expression among all rats. The liver 18:3 n -6/18:2 n -6 ratio, but not Fads2 mRNA expression, was also positively correlated with erythrocyte and frontal cortex LC n -6 fatty acid compositions. Neither Fads1 or Fads2 mRNA expression was altered in brain cortex of DEF rats. These results confirm previous findings that liver, but not brain, delta6-desaturase expression and activity indices are negatively regulated by dietary n -3 fatty acids.</description><subject>Acetyltransferases</subject><subject>Acetyltransferases - genetics</subject><subject>Acetyltransferases - metabolism</subject><subject>administration & dosage</subject><subject>adults</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>biosynthesis</subject><subject>blood</subject><subject>brain</subject><subject>Brain - metabolism</subject><subject>correlation</subject><subject>cortex</subject><subject>Delta5-desaturase ( Fads1)</subject><subject>Delta6-desaturase ( Fads2)</subject><subject>Diet</subject><subject>Elongase-2/5 ( Elovl2, Elovl5)</subject><subject>Erythrocyte</subject><subject>erythrocytes</subject><subject>fatty acid composition</subject><subject>Fatty Acids, Omega-3</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Fatty Acids, Omega-3 - blood</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Frontal cortex</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>gene expression</subject><subject>genetics</subject><subject>Linoleoyl-CoA Desaturase</subject><subject>Linoleoyl-CoA Desaturase - genetics</subject><subject>Linoleoyl-CoA Desaturase - metabolism</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>messenger RNA</subject><subject>metabolism</subject><subject>Omega-3 fatty acid</subject><subject>omega-3 fatty acids</subject><subject>polyunsaturated fatty acids</subject><subject>Rat</subject><subject>Rats</subject><subject>repletion</subject><subject>RNA, Messenger</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Up-Regulation</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0271-5317</issn><issn>1879-0739</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksuO0zAUhiMEYoaBN0DIGwSblOPYiRMWSGjETRppFsDacuzj4uI6xXYqykvxirjTMsNFglWk5Du_f598VfWQwoIC7Z6tFmHOEdOiAUoX0C8AxK3qlPZiqEGw4XZ1Co2gdcuoOKnupbQCoIIydrc6aRpoOB-60-r75RqXqmbEqpx3RGlniEHrtMOgdyShR53dFv2OzJs64nL2KmMqjM-qqw0mleeoEhL8uiltkpsCUcGUpDLmSqQLxuky4QKJKhNfwuJzUtgthrynxx0JU1wr776pqxeTJdPfrVIuJ6X71R2rfMIHx-dZ9fH1qw_nb-uLyzfvzl9e1LrtIde6b5mgne5wNLYbe1BcGDFqrvpu5NiCGoBa27aMd0NjhGWjZc1gYTAMhFXsrHpxyN3M4xqNLl2j8nIT3VrFnZyUk79_Ce6TXE5bycpqu2EoAU-OAXH6MmPKcu2SRu9VwGlOcgDoOPCWFvLpP0nKGe2ahvKmoPyA6jilFNFeF6Ig91bIlTxYIfdWSOhlsaKMPfr1MtdDPzUowOMjoJJW3kYVtEs3HBcljsPNVrCsfuswynQlChoXiyfSTO5_Tf4M0N4FV878jDtMq2mOofxWSWVqJMj3e4P3AlNa5G3ZwH4AuRbxpg</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Hofacer, Rylon</creator><creator>Jandacek, Ronald</creator><creator>Rider, Therese</creator><creator>Tso, Patrick</creator><creator>Magrisso, I. Jack</creator><creator>Benoit, Stephen C</creator><creator>McNamara, Robert K</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110901</creationdate><title>Omega-3 fatty acid deficiency selectively up-regulates delta6-desaturase expression and activity indices in rat liver: prevention by normalization of omega-3 fatty acid status</title><author>Hofacer, Rylon ; Jandacek, Ronald ; Rider, Therese ; Tso, Patrick ; Magrisso, I. Jack ; Benoit, Stephen C ; McNamara, Robert K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-c853716c6ebdf6b80a47d7bc4a86b4e50a901ff5534692d7f3bf329f09d307fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetyltransferases</topic><topic>Acetyltransferases - genetics</topic><topic>Acetyltransferases - metabolism</topic><topic>administration & dosage</topic><topic>adults</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>biosynthesis</topic><topic>blood</topic><topic>brain</topic><topic>Brain - metabolism</topic><topic>correlation</topic><topic>cortex</topic><topic>Delta5-desaturase ( Fads1)</topic><topic>Delta6-desaturase ( Fads2)</topic><topic>Diet</topic><topic>Elongase-2/5 ( Elovl2, Elovl5)</topic><topic>Erythrocyte</topic><topic>erythrocytes</topic><topic>fatty acid composition</topic><topic>Fatty Acids, Omega-3</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Fatty Acids, Omega-3 - blood</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Frontal cortex</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology and Hepatology</topic><topic>gene expression</topic><topic>genetics</topic><topic>Linoleoyl-CoA Desaturase</topic><topic>Linoleoyl-CoA Desaturase - genetics</topic><topic>Linoleoyl-CoA Desaturase - metabolism</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>messenger RNA</topic><topic>metabolism</topic><topic>Omega-3 fatty acid</topic><topic>omega-3 fatty acids</topic><topic>polyunsaturated fatty acids</topic><topic>Rat</topic><topic>Rats</topic><topic>repletion</topic><topic>RNA, Messenger</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Up-Regulation</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hofacer, Rylon</creatorcontrib><creatorcontrib>Jandacek, Ronald</creatorcontrib><creatorcontrib>Rider, Therese</creatorcontrib><creatorcontrib>Tso, Patrick</creatorcontrib><creatorcontrib>Magrisso, I. Jack</creatorcontrib><creatorcontrib>Benoit, Stephen C</creatorcontrib><creatorcontrib>McNamara, Robert K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrition research (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hofacer, Rylon</au><au>Jandacek, Ronald</au><au>Rider, Therese</au><au>Tso, Patrick</au><au>Magrisso, I. Jack</au><au>Benoit, Stephen C</au><au>McNamara, Robert K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Omega-3 fatty acid deficiency selectively up-regulates delta6-desaturase expression and activity indices in rat liver: prevention by normalization of omega-3 fatty acid status</atitle><jtitle>Nutrition research (New York, N.Y.)</jtitle><addtitle>Nutr Res</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>31</volume><issue>9</issue><spage>715</spage><epage>722</epage><pages>715-722</pages><issn>0271-5317</issn><eissn>1879-0739</eissn><coden>NTRSDC</coden><abstract>Abstract This study investigated the effects of perinatal dietary omega-3 ( n -3) fatty acid depletion and subsequent repletion on the expression of genes that regulate long-chain (LC) polyunsaturated fatty acid biosynthesis in rat liver and brain. It was hypothesized that chronic n -3 fatty acid deficiency would increase liver Fads1 and Fads2 messenger RNA (mRNA) expression/activity and that n -3 fatty acid repletion would normalize this response. Adult rats fed the n -3–free diet during perinatal development exhibited significantly lower erythrocyte, liver, and frontal cortex LC n -3 fatty acid composition and reciprocal elevations in LC omega-6 ( n -6) fatty acid composition compared with controls (CONs) and repleted rats. Liver Fads2 , but not Fads1 , Elovl2 , or Elovl5 , mRNA expression was significantly greater in n- 3–deficient (DEF) rats compared with CONs and was partially normalized in repleted rats. The liver 18:3 n -6/18:2 n -6 ratio, an index of delta6-desturase activity, was significantly greater in DEF rats compared with CON and repleted rats and was positively correlated with Fads2 mRNA expression among all rats. The liver 18:3 n -6/18:2 n -6 ratio, but not Fads2 mRNA expression, was also positively correlated with erythrocyte and frontal cortex LC n -6 fatty acid compositions. Neither Fads1 or Fads2 mRNA expression was altered in brain cortex of DEF rats. These results confirm previous findings that liver, but not brain, delta6-desaturase expression and activity indices are negatively regulated by dietary n -3 fatty acids.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22024496</pmid><doi>10.1016/j.nutres.2011.08.007</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrition research (New York, N.Y.), 2011-09, Vol.31 (9), p.715-722 |
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| subjects | Acetyltransferases Acetyltransferases - genetics Acetyltransferases - metabolism administration & dosage adults Animals Biological and medical sciences biosynthesis blood brain Brain - metabolism correlation cortex Delta5-desaturase ( Fads1) Delta6-desaturase ( Fads2) Diet Elongase-2/5 ( Elovl2, Elovl5) Erythrocyte erythrocytes fatty acid composition Fatty Acids, Omega-3 Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - blood Feeding. Feeding behavior Female Frontal cortex Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology gene expression genetics Linoleoyl-CoA Desaturase Linoleoyl-CoA Desaturase - genetics Linoleoyl-CoA Desaturase - metabolism Liver Liver - metabolism Male messenger RNA metabolism Omega-3 fatty acid omega-3 fatty acids polyunsaturated fatty acids Rat Rats repletion RNA, Messenger RNA, Messenger - genetics RNA, Messenger - metabolism Up-Regulation Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Omega-3 fatty acid deficiency selectively up-regulates delta6-desaturase expression and activity indices in rat liver: prevention by normalization of omega-3 fatty acid status |
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