TVP1022 Protects Neonatal Rat Ventricular Myocytes against Doxorubicin-Induced Functional Derangements

Our recent studies demonstrated that propargylamine derivatives such as rasagiline (Azilect, Food and Drug Administration-approved anti-Parkinson drug) and its S -isomer TVP1022 protect cardiac and neuronal cell cultures against apoptotic-inducing stimuli. Studies on structure-activity relationship...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2010-02, Vol.332 (2), p.413-420
Hauptverfasser:	Berdichevski, Alexandra, Meiry, Gideon, Milman, Felix, Reiter, Irena, Sedan, Oshra, Eliyahu, Sivan, Duffy, Heather S, Youdim, Moussa B, Binah, Ofer
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Calcium - metabolism Calcium-Binding Proteins - metabolism Cardiotonic Agents - pharmacology Cardiotoxins - pharmacology Cells, Cultured Connexin 43 - metabolism Doxorubicin - adverse effects Doxorubicin - antagonists & inhibitors Indans - pharmacology Intercellular Junctions - drug effects Myocardial Contraction - drug effects Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Rats Rats, Sprague-Dawley
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