Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function

Occludin is a transmembrane tight junction (TJ) protein that plays an important role in TJ assembly and regulation of the epithelial barrier function, but the mechanisms underlying its post-transcriptional regulation are unknown. The RNA-binding protein HuR modulates the stability and translation of...

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Veröffentlicht in:	Nucleic acids research 2011-10, Vol.39 (19), p.8472-8487
Hauptverfasser:	Yu, Ting-Xi, Wang, Peng-Yuan, Rao, Jaladanki N., Zou, Tongtong, Liu, Lan, Xiao, Lan, Gorospe, Myriam, Wang, Jian-Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Cell Membrane Permeability Cells, Cultured Checkpoint Kinase 2 ELAV Proteins - metabolism Gene Expression Regulation Intestinal Mucosa - metabolism Male Membrane Proteins - biosynthesis Membrane Proteins - genetics Mice Molecular Biology Occludin Phosphorylation Polyamines - metabolism Protein Biosynthesis Protein-Serine-Threonine Kinases - metabolism Rats RNA, Messenger - metabolism Sepsis - enzymology Sepsis - genetics
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