The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

Aberrant DNA methylation is often associated with cancer and the formation of tumors; however, the underlying mechanisms, in particular the recruitment and regulation of DNA methyltransferases remain largely unknown. In this study, we identified USP7 as an interaction partner of Dnmt1 and UHRF1 in v...

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Veröffentlicht in:	Nucleic acids research 2011-10, Vol.39 (19), p.8355-8365
Hauptverfasser:	Felle, Max, Joppien, Saskia, Németh, Attila, Diermeier, Sarah, Thalhammer, Verena, Dobner, Thomas, Kremmer, Elisabeth, Kappler, Roland, Längst, Gernot
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer CCAAT-Enhancer-Binding Proteins - metabolism Cell Line Chromatin Chromatin - metabolism DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation DNA methyltransferase DNMT1 protein Enzymatic activity Enzyme Activation Gene Regulation, Chromatin and Epigenetics Gene silencing Humans Protein Stability Protein turnover Recruitment Tumors Ubiquitin - metabolism Ubiquitin Thiolesterase - metabolism Ubiquitin-Specific Peptidase 7
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