BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia

Chronic myeloid leukemia (CML) is induced by the oncogenic BCR-ABL1 tyrosine kinase and can be effectively treated for many years with tyrosine kinase inhibitors (TKIs). However, unless CML patients receive life-long TKI treatment, leukemia will eventually recur; this is attributed to the failure of...

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Veröffentlicht in:	The Journal of experimental medicine 2011-10, Vol.208 (11), p.2163-2174
Hauptverfasser:	Hurtz, Christian, Hatzi, Katerina, Cerchietti, Leandro, Braig, Melanie, Park, Eugene, Kim, Yong-mi, Herzog, Sebastian, Ramezani-Rad, Parham, Jumaa, Hassan, Müller, Martin C, Hofmann, Wolf-Karsten, Hochhaus, Andreas, Ye, B Hilda, Agarwal, Anupriya, Druker, Brian J, Shah, Neil P, Melnick, Ari M, Müschen, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD34 - metabolism Benzamides Brief Definitive Report Cell Survival Disease Models, Animal DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Forkhead Transcription Factors - metabolism Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - physiopathology Mice Mice, Inbred NOD Mice, Knockout Mice, SCID Neoplasm Transplantation Neoplastic Stem Cells - physiology Piperazines - therapeutic use Protein Kinase Inhibitors - therapeutic use Protein-Tyrosine Kinases - antagonists & inhibitors Proto-Oncogene Proteins c-bcl-6 Pyrimidines - therapeutic use Tumor Cells, Cultured Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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