Hair cell death in a hearing-deficient canary
Cell death has been documented in bird auditory inner ear epithelia after induced damage. This cell death is quickly followed by an increase in supporting cell division and regeneration of the epithelium, thereby suggesting a possible relationship between these two processes. However, aspects of thi...
Gespeichert in:
Veröffentlicht in: | Journal of the Association for Research in Otolaryngology 2001-03, Vol.2 (1), p.79-86 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 86 |
---|---|
container_issue | 1 |
container_start_page | 79 |
container_title | Journal of the Association for Research in Otolaryngology |
container_volume | 2 |
creator | Wilkins, H R Presson, J C Popper, A N Ryals, B M Dooling, R J |
description | Cell death has been documented in bird auditory inner ear epithelia after induced damage. This cell death is quickly followed by an increase in supporting cell division and regeneration of the epithelium, thereby suggesting a possible relationship between these two processes. However, aspects of this relationship still need to be better understood. The Belgian Waterslager (BWS) canary is an ideal system in which to study cell death and subsequent cell division. In contrast to mixed breed (MB) canaries, cell division normally occurs in the auditory end organ of the BWS without any external manipulation. In addition, some of the cells in the auditory epithelium may be dying through an apoptotic-like process. In the present study two methods were used to quantify dying cells in the BWS and MB canary auditory epithelia: morphological criteria and TUNEL. Results confirm that some of the abnormal hair cells in the BWS auditory epithelium are apoptotic-like. The presence of both cell death and cell division indicates that these processes act concurrently in the adult end organ. Future studies are needed to determine if cell death is a stimulus for the observed cell division. |
doi_str_mv | 10.1007/s101620010025 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3201090</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71147902</sourcerecordid><originalsourceid>FETCH-LOGICAL-c383t-6efb9d472e2e22adab97b466f18b4d0918e1321b318b15142bb3738269b6f5d83</originalsourceid><addsrcrecordid>eNpVkM1LAzEUxIMotlaPXmVP3qJ5-dxcBCnVCgUveg7JbraNbHdrshX8701pUUsOyZAf8-YNQtdA7oAQdZ-AgKSEZEHFCRoDZyVWQrHT_BZUYKYljNBFSh8ZUkLqczQCEFyAYGOE5zbEovJtW9TeDqsidIUtVt7G0C1x7ZtQBd8NRWU7G78v0Vlj2-SvDvcEvT_N3qZzvHh9fpk-LnDFSjZg6Runa66oz4fa2jqtHJeygdLxmmgoPTAKjmUNAjh1jilWUqmdbERdsgl62Ptutm7t6yoniLY1mxjWOYXpbTDHP11YmWX_ZRjNRWiSDW4PBrH_3Po0mHVIuy1t5_ttMgqAK01oBvEerGKfUvTN7xAgZlewOSo48zf_k_3Rh0bZD2vBdJ0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71147902</pqid></control><display><type>article</type><title>Hair cell death in a hearing-deficient canary</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>PubMed Central</source><creator>Wilkins, H R ; Presson, J C ; Popper, A N ; Ryals, B M ; Dooling, R J</creator><creatorcontrib>Wilkins, H R ; Presson, J C ; Popper, A N ; Ryals, B M ; Dooling, R J</creatorcontrib><description>Cell death has been documented in bird auditory inner ear epithelia after induced damage. This cell death is quickly followed by an increase in supporting cell division and regeneration of the epithelium, thereby suggesting a possible relationship between these two processes. However, aspects of this relationship still need to be better understood. The Belgian Waterslager (BWS) canary is an ideal system in which to study cell death and subsequent cell division. In contrast to mixed breed (MB) canaries, cell division normally occurs in the auditory end organ of the BWS without any external manipulation. In addition, some of the cells in the auditory epithelium may be dying through an apoptotic-like process. In the present study two methods were used to quantify dying cells in the BWS and MB canary auditory epithelia: morphological criteria and TUNEL. Results confirm that some of the abnormal hair cells in the BWS auditory epithelium are apoptotic-like. The presence of both cell death and cell division indicates that these processes act concurrently in the adult end organ. Future studies are needed to determine if cell death is a stimulus for the observed cell division.</description><identifier>ISSN: 1525-3961</identifier><identifier>EISSN: 1438-7573</identifier><identifier>DOI: 10.1007/s101620010025</identifier><identifier>PMID: 11545153</identifier><language>eng</language><publisher>United States: Springer-Verlag</publisher><subject>Animals ; Apoptosis ; Basilar Membrane - pathology ; Basilar Membrane - physiopathology ; Canaries - physiology ; Cell Death ; Deafness - pathology ; Deafness - physiopathology ; DNA Fragmentation ; Hair Cells, Auditory - physiology ; In Situ Nick-End Labeling</subject><ispartof>Journal of the Association for Research in Otolaryngology, 2001-03, Vol.2 (1), p.79-86</ispartof><rights>Association for Research in Otolaryngology 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-6efb9d472e2e22adab97b466f18b4d0918e1321b318b15142bb3738269b6f5d83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201090/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201090/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11545153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilkins, H R</creatorcontrib><creatorcontrib>Presson, J C</creatorcontrib><creatorcontrib>Popper, A N</creatorcontrib><creatorcontrib>Ryals, B M</creatorcontrib><creatorcontrib>Dooling, R J</creatorcontrib><title>Hair cell death in a hearing-deficient canary</title><title>Journal of the Association for Research in Otolaryngology</title><addtitle>J Assoc Res Otolaryngol</addtitle><description>Cell death has been documented in bird auditory inner ear epithelia after induced damage. This cell death is quickly followed by an increase in supporting cell division and regeneration of the epithelium, thereby suggesting a possible relationship between these two processes. However, aspects of this relationship still need to be better understood. The Belgian Waterslager (BWS) canary is an ideal system in which to study cell death and subsequent cell division. In contrast to mixed breed (MB) canaries, cell division normally occurs in the auditory end organ of the BWS without any external manipulation. In addition, some of the cells in the auditory epithelium may be dying through an apoptotic-like process. In the present study two methods were used to quantify dying cells in the BWS and MB canary auditory epithelia: morphological criteria and TUNEL. Results confirm that some of the abnormal hair cells in the BWS auditory epithelium are apoptotic-like. The presence of both cell death and cell division indicates that these processes act concurrently in the adult end organ. Future studies are needed to determine if cell death is a stimulus for the observed cell division.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Basilar Membrane - pathology</subject><subject>Basilar Membrane - physiopathology</subject><subject>Canaries - physiology</subject><subject>Cell Death</subject><subject>Deafness - pathology</subject><subject>Deafness - physiopathology</subject><subject>DNA Fragmentation</subject><subject>Hair Cells, Auditory - physiology</subject><subject>In Situ Nick-End Labeling</subject><issn>1525-3961</issn><issn>1438-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1LAzEUxIMotlaPXmVP3qJ5-dxcBCnVCgUveg7JbraNbHdrshX8701pUUsOyZAf8-YNQtdA7oAQdZ-AgKSEZEHFCRoDZyVWQrHT_BZUYKYljNBFSh8ZUkLqczQCEFyAYGOE5zbEovJtW9TeDqsidIUtVt7G0C1x7ZtQBd8NRWU7G78v0Vlj2-SvDvcEvT_N3qZzvHh9fpk-LnDFSjZg6Runa66oz4fa2jqtHJeygdLxmmgoPTAKjmUNAjh1jilWUqmdbERdsgl62Ptutm7t6yoniLY1mxjWOYXpbTDHP11YmWX_ZRjNRWiSDW4PBrH_3Po0mHVIuy1t5_ttMgqAK01oBvEerGKfUvTN7xAgZlewOSo48zf_k_3Rh0bZD2vBdJ0</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>Wilkins, H R</creator><creator>Presson, J C</creator><creator>Popper, A N</creator><creator>Ryals, B M</creator><creator>Dooling, R J</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20010301</creationdate><title>Hair cell death in a hearing-deficient canary</title><author>Wilkins, H R ; Presson, J C ; Popper, A N ; Ryals, B M ; Dooling, R J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-6efb9d472e2e22adab97b466f18b4d0918e1321b318b15142bb3738269b6f5d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Basilar Membrane - pathology</topic><topic>Basilar Membrane - physiopathology</topic><topic>Canaries - physiology</topic><topic>Cell Death</topic><topic>Deafness - pathology</topic><topic>Deafness - physiopathology</topic><topic>DNA Fragmentation</topic><topic>Hair Cells, Auditory - physiology</topic><topic>In Situ Nick-End Labeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilkins, H R</creatorcontrib><creatorcontrib>Presson, J C</creatorcontrib><creatorcontrib>Popper, A N</creatorcontrib><creatorcontrib>Ryals, B M</creatorcontrib><creatorcontrib>Dooling, R J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the Association for Research in Otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilkins, H R</au><au>Presson, J C</au><au>Popper, A N</au><au>Ryals, B M</au><au>Dooling, R J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hair cell death in a hearing-deficient canary</atitle><jtitle>Journal of the Association for Research in Otolaryngology</jtitle><addtitle>J Assoc Res Otolaryngol</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>2</volume><issue>1</issue><spage>79</spage><epage>86</epage><pages>79-86</pages><issn>1525-3961</issn><eissn>1438-7573</eissn><abstract>Cell death has been documented in bird auditory inner ear epithelia after induced damage. This cell death is quickly followed by an increase in supporting cell division and regeneration of the epithelium, thereby suggesting a possible relationship between these two processes. However, aspects of this relationship still need to be better understood. The Belgian Waterslager (BWS) canary is an ideal system in which to study cell death and subsequent cell division. In contrast to mixed breed (MB) canaries, cell division normally occurs in the auditory end organ of the BWS without any external manipulation. In addition, some of the cells in the auditory epithelium may be dying through an apoptotic-like process. In the present study two methods were used to quantify dying cells in the BWS and MB canary auditory epithelia: morphological criteria and TUNEL. Results confirm that some of the abnormal hair cells in the BWS auditory epithelium are apoptotic-like. The presence of both cell death and cell division indicates that these processes act concurrently in the adult end organ. Future studies are needed to determine if cell death is a stimulus for the observed cell division.</abstract><cop>United States</cop><pub>Springer-Verlag</pub><pmid>11545153</pmid><doi>10.1007/s101620010025</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1525-3961 |
ispartof | Journal of the Association for Research in Otolaryngology, 2001-03, Vol.2 (1), p.79-86 |
issn | 1525-3961 1438-7573 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3201090 |
source | MEDLINE; SpringerLink Journals; PubMed Central |
subjects | Animals Apoptosis Basilar Membrane - pathology Basilar Membrane - physiopathology Canaries - physiology Cell Death Deafness - pathology Deafness - physiopathology DNA Fragmentation Hair Cells, Auditory - physiology In Situ Nick-End Labeling |
title | Hair cell death in a hearing-deficient canary |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A08%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hair%20cell%20death%20in%20a%20hearing-deficient%20canary&rft.jtitle=Journal%20of%20the%20Association%20for%20Research%20in%20Otolaryngology&rft.au=Wilkins,%20H%20R&rft.date=2001-03-01&rft.volume=2&rft.issue=1&rft.spage=79&rft.epage=86&rft.pages=79-86&rft.issn=1525-3961&rft.eissn=1438-7573&rft_id=info:doi/10.1007/s101620010025&rft_dat=%3Cproquest_pubme%3E71147902%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71147902&rft_id=info:pmid/11545153&rfr_iscdi=true |